Hereditary ovarian carcinoma. Biomarker studies

Henry T. Lynch, G. S. Schuelke, I. C. Wells, Shih-Chuan Cheng, W. J. Kimberling, K. A. Biscone, B. S. Danes

Research output: Contribution to journalArticle

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Abstract

Three ovarian-cancer-prone kindreds were studied, 2 of which contained identical twin sisters concordant for ovarian carcinoma. In one kindred, both identical twin sisters had daughters with ovarian carcinoma. In another kindred, one of the identical twin sisters had an ovarian-cancer affected daughter. Ovarian carcinoma showed vertical transmission in all 3 families in a pattern consonant with an autosomal dominant mode of inheritance. Medical-genetic survey of each family included detailed questionnaires with retrieval of primary medical and pathology documents on cancer of all anatomic sites. Putative biomarker determinations included: (1) in vitro hyperdiploidy in dermal monolayer cultures; and (2) lower serum levels of alpha-L-fucosidase (≤275 IU/ml) in all cancer-affected patients and statistically significant lower levels in 50% risk individuals when compared to spouse and published controls (P = 0.04 and P = 0.0002, respectively). These findings are discussed in context with the eventual development of a risk factor profile which, given acceptable sensitivity and specificity, would enable identification of individuals who would be prime candidates for intensive surveillance/management programs.

Original languageEnglish
Pages (from-to)410-415
Number of pages6
JournalCancer
Volume55
Issue number2
DOIs
StatePublished - 1985

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Monozygotic Twins
Siblings
Biomarkers
Carcinoma
Nuclear Family
Ovarian Neoplasms
alpha-L-Fucosidase
Polyploidy
Medical Genetics
Spouses
Neoplasms
Pathology
Sensitivity and Specificity
Skin
Serum
Surveys and Questionnaires

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Lynch, H. T., Schuelke, G. S., Wells, I. C., Cheng, S-C., Kimberling, W. J., Biscone, K. A., & Danes, B. S. (1985). Hereditary ovarian carcinoma. Biomarker studies. Cancer, 55(2), 410-415. https://doi.org/10.1002/1097-0142(19850115)55:2<410::AID-CNCR2820550220>3.0.CO;2-Q

Hereditary ovarian carcinoma. Biomarker studies. / Lynch, Henry T.; Schuelke, G. S.; Wells, I. C.; Cheng, Shih-Chuan; Kimberling, W. J.; Biscone, K. A.; Danes, B. S.

In: Cancer, Vol. 55, No. 2, 1985, p. 410-415.

Research output: Contribution to journalArticle

Lynch, HT, Schuelke, GS, Wells, IC, Cheng, S-C, Kimberling, WJ, Biscone, KA & Danes, BS 1985, 'Hereditary ovarian carcinoma. Biomarker studies', Cancer, vol. 55, no. 2, pp. 410-415. https://doi.org/10.1002/1097-0142(19850115)55:2<410::AID-CNCR2820550220>3.0.CO;2-Q
Lynch, Henry T. ; Schuelke, G. S. ; Wells, I. C. ; Cheng, Shih-Chuan ; Kimberling, W. J. ; Biscone, K. A. ; Danes, B. S. / Hereditary ovarian carcinoma. Biomarker studies. In: Cancer. 1985 ; Vol. 55, No. 2. pp. 410-415.
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