Hereditary Pancreatic Cancer

Henry T. Lynch, Randall E. Brand, Carolyn A. Deters, Trudy G. Shaw, Jane F. Lynch

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Hereditary pancreatic cancer (PC) appears to be exceedingly heterogeneous, as evidenced by its association with a variety of integrally associated diverse cancers and/or differing mendelian inherited cancer syndromes, which include the Lynch syndrome II variant of hereditary nonpolyposis colorectal cancer, hereditary breast-ovarian cancer syndrome in families with the BRCA2 mutation, hereditary pancreatitis, Peutz-Jeghers polyposis and the familial atypical multiple-mole melanoma syndrome in families with the CDKN2A (p16) germline mutation. Because of this heterogeneity, we provide a conservative estimate that about 5% (1,460) of PC cases in the US annually are hereditary. Although this number is relatively small, members of hereditary PC families serve as excellent models for studying the etiology, natural history, biomarkers, pathogenesis, potential carcinogenic exposures and their perturbation of underlying genetic events, and treatment of PC. These individuals would benefit greatly from method(s) capable of detecting cancer at an early stage, and such knowledge would also be useful for improving the diagnosis of the much more common 'sporadic' form of PC.

Original languageEnglish
Pages (from-to)466-471
Number of pages6
JournalPancreatology
Volume1
Issue number5
DOIs
StatePublished - 2001

Fingerprint

Pancreatic Neoplasms
Lynch Syndrome II
Hereditary Breast and Ovarian Cancer Syndrome
Dysplastic Nevus Syndrome
Peutz-Jeghers Syndrome
Hereditary Nonpolyposis Colorectal Neoplasms
Neoplasms
Germ-Line Mutation
Natural History
Biomarkers
Breast Neoplasms
Mutation
Therapeutics

All Science Journal Classification (ASJC) codes

  • Endocrinology
  • Gastroenterology

Cite this

Lynch, H. T., Brand, R. E., Deters, C. A., Shaw, T. G., & Lynch, J. F. (2001). Hereditary Pancreatic Cancer. Pancreatology, 1(5), 466-471. https://doi.org/10.1159/000055849

Hereditary Pancreatic Cancer. / Lynch, Henry T.; Brand, Randall E.; Deters, Carolyn A.; Shaw, Trudy G.; Lynch, Jane F.

In: Pancreatology, Vol. 1, No. 5, 2001, p. 466-471.

Research output: Contribution to journalArticle

Lynch, HT, Brand, RE, Deters, CA, Shaw, TG & Lynch, JF 2001, 'Hereditary Pancreatic Cancer', Pancreatology, vol. 1, no. 5, pp. 466-471. https://doi.org/10.1159/000055849
Lynch HT, Brand RE, Deters CA, Shaw TG, Lynch JF. Hereditary Pancreatic Cancer. Pancreatology. 2001;1(5):466-471. https://doi.org/10.1159/000055849
Lynch, Henry T. ; Brand, Randall E. ; Deters, Carolyn A. ; Shaw, Trudy G. ; Lynch, Jane F. / Hereditary Pancreatic Cancer. In: Pancreatology. 2001 ; Vol. 1, No. 5. pp. 466-471.
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