Hereditary progressive atrioventricular conduction defect

Henry T. Lynch, Syed Mohiuddin, Jane Moran, Arnold Kaplan, Michael Sketch, Alan Zencka, Vincent Runco

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Abstract

New data on genetics, including an extensive pedigree and certain aspects of natural history, have been compiled on Family S, which is characterized by a hereditary progressive atrioventricular (A-V) conduction defect. Concordance analysis of heart block in affected parents and their offspring suggests as a working hypothesis transmission of diathesis for the defect by means of a Mendelian autosomal dominant factor. Regression of the defect in several relatives, including reversion from first degree heart block to normal A-V conduction, defies explanation at this time. However, rapport established with the unusually large (1,067 members) and cooperative kindred will permit longitudinal evaluation of these findings.

Original languageEnglish (US)
Pages (from-to)297-301
Number of pages5
JournalThe American Journal of Cardiology
Volume36
Issue number3
DOIs
StatePublished - Sep 1975

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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    Lynch, H. T., Mohiuddin, S., Moran, J., Kaplan, A., Sketch, M., Zencka, A., & Runco, V. (1975). Hereditary progressive atrioventricular conduction defect. The American Journal of Cardiology, 36(3), 297-301. https://doi.org/10.1016/0002-9149(75)90479-8