Hereditary progressive atrioventricular conduction defect

Henry T. Lynch, Syed M. Mohiuddin, Jane Moran, Arnold Kaplan, Michael Sketch, Alan Zencka, Vincent Runco

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

New data on genetics, including an extensive pedigree and certain aspects of natural history, have been compiled on Family S, which is characterized by a hereditary progressive atrioventricular (A-V) conduction defect. Concordance analysis of heart block in affected parents and their offspring suggests as a working hypothesis transmission of diathesis for the defect by means of a Mendelian autosomal dominant factor. Regression of the defect in several relatives, including reversion from first degree heart block to normal A-V conduction, defies explanation at this time. However, rapport established with the unusually large (1,067 members) and cooperative kindred will permit longitudinal evaluation of these findings.

Original languageEnglish
Pages (from-to)297-301
Number of pages5
JournalAmerican Journal of Cardiology
Volume36
Issue number3
DOIs
StatePublished - 1975

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Heart Block
Disease Susceptibility
Pedigree
Natural History

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Hereditary progressive atrioventricular conduction defect. / Lynch, Henry T.; Mohiuddin, Syed M.; Moran, Jane; Kaplan, Arnold; Sketch, Michael; Zencka, Alan; Runco, Vincent.

In: American Journal of Cardiology, Vol. 36, No. 3, 1975, p. 297-301.

Research output: Contribution to journalArticle

Lynch, Henry T. ; Mohiuddin, Syed M. ; Moran, Jane ; Kaplan, Arnold ; Sketch, Michael ; Zencka, Alan ; Runco, Vincent. / Hereditary progressive atrioventricular conduction defect. In: American Journal of Cardiology. 1975 ; Vol. 36, No. 3. pp. 297-301.
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