Hereditary Progressive Atrioventricular Conduction Defect: A New Syndrome?

Henry T. Lynch, Syed Mohiuddin, Michael H. Sketch, Anne J. Krush, Stephen Carter, Vincent Runco

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Abstract

We studied a syndrome involving a progressive atrioventricular conduction defect in three generations of a large family. Clinical findings included a slow heart rate, episodes of lightheadedness, syncope, and absence of predisposing acquired or hereditary cardiac disorders. Electrocardiography showed a prolonged atrioventricular conduction with onset usually in the 30s, loss of R waves in the right precordial leads, and arrhythmia that occurs only as a late manifestation. Progression from first-degree to complete heart block was usually slow, but occasionally a fulminant course led to sudden death within two or three years. Specific differences from other forms of conduction defects suggest that this is a new hereditary syndrome.

Original languageEnglish (US)
Pages (from-to)1465-1470
Number of pages6
JournalJAMA: The Journal of the American Medical Association
Volume225
Issue number12
DOIs
StatePublished - Sep 17 1973

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

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