We studied a syndrome involving a progressive atrioventricular conduction defect in three generations of a large family. Clinical findings included a slow heart rate, episodes of lightheadedness, syncope, and absence of predisposing acquired or hereditary cardiac disorders. Electrocardiography showed a prolonged atrioventricular conduction with onset usually in the 30s, loss of R waves in the right precordial leads, and arrhythmia that occurs only as a late manifestation. Progression from first-degree to complete heart block was usually slow, but occasionally a fulminant course led to sudden death within two or three years. Specific differences from other forms of conduction defects suggest that this is a new hereditary syndrome.
|Number of pages||6|
|Journal||JAMA - Journal of the American Medical Association|
|Publication status||Published - Sep 17 1973|
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