Hereditary Progressive Atrioventricular Conduction Defect

A New Syndrome?

Henry T. Lynch, Syed M. Mohiuddin, Michael H. Sketch, Anne J. Krush, Stephen Carter, Vincent Runco

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

We studied a syndrome involving a progressive atrioventricular conduction defect in three generations of a large family. Clinical findings included a slow heart rate, episodes of lightheadedness, syncope, and absence of predisposing acquired or hereditary cardiac disorders. Electrocardiography showed a prolonged atrioventricular conduction with onset usually in the 30s, loss of R waves in the right precordial leads, and arrhythmia that occurs only as a late manifestation. Progression from first-degree to complete heart block was usually slow, but occasionally a fulminant course led to sudden death within two or three years. Specific differences from other forms of conduction defects suggest that this is a new hereditary syndrome.

Original languageEnglish
Pages (from-to)1465-1470
Number of pages6
JournalJAMA - Journal of the American Medical Association
Volume225
Issue number12
DOIs
StatePublished - Sep 17 1973

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Heart Block
Syncope
Dizziness
Sudden Death
Cardiac Arrhythmias
Electrocardiography
Heart Rate

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Hereditary Progressive Atrioventricular Conduction Defect : A New Syndrome? / Lynch, Henry T.; Mohiuddin, Syed M.; Sketch, Michael H.; Krush, Anne J.; Carter, Stephen; Runco, Vincent.

In: JAMA - Journal of the American Medical Association, Vol. 225, No. 12, 17.09.1973, p. 1465-1470.

Research output: Contribution to journalArticle

Lynch, Henry T. ; Mohiuddin, Syed M. ; Sketch, Michael H. ; Krush, Anne J. ; Carter, Stephen ; Runco, Vincent. / Hereditary Progressive Atrioventricular Conduction Defect : A New Syndrome?. In: JAMA - Journal of the American Medical Association. 1973 ; Vol. 225, No. 12. pp. 1465-1470.
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