High-Density Lipoprotein: A Novel Target for Antirestenosis Therapy

Kai Yin, Devendra K. Agrawal

    Research output: Contribution to journalReview articlepeer-review

    11 Scopus citations


    Restenosis is an integral pathological process central to the recurrent vessel narrowing after interventional procedures. Although the mechanisms for restenosis are diverse in different pathological conditions, endothelial dysfunction, inflammation, vascular smooth muscle cell (SMC) proliferation, and myofibroblasts transition have been thought to play crucial role in the development of restenosis. Indeed, there is an inverse relationship between high-density lipoprotein (HDL) levels and risk for coronary heart disease (CHD). However, relatively studies on the direct assessment of HDL effect on restenosis are limited. In addition to involvement in the cholesterol reverse transport, many vascular protective effects of HDL, including protection of endothelium, antiinflammation, antithrombus actions, inhibition of SMC proliferation, and regulation by adventitial effects may contribute to the inhibition of restenosis, though the exact relationships between HDL and restenosis remain to be elucidated. This review summarizes the vascular protective effects of HDL, emphasizing the potential role of HDL in intimal hyperplasia and vascular remodeling, which may provide novel prophylactic and therapeutic strategies for antirestenosis.

    Original languageEnglish
    Pages (from-to)500-511
    Number of pages12
    JournalClinical and Translational Science
    Issue number6
    StatePublished - Dec 1 2014

    All Science Journal Classification (ASJC) codes

    • Medicine(all)
    • Biochemistry, Genetics and Molecular Biology(all)
    • Neuroscience(all)
    • Pharmacology, Toxicology and Pharmaceutics(all)


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