Hippocampal neuroplasticity induced by early-life stress: Functional and molecular aspects

Kristina A. Fenoglio; Kristen L. Brunson; Tallie Z. Baram

doi:10.1016/j.yfrne.2006.02.001

Hippocampal neuroplasticity induced by early-life stress: Functional and molecular aspects

Kristina A. Fenoglio, Kristen L. Brunson, Tallie Z. Baram

Research output: Contribution to journal › Review article › peer-review

155 Scopus citations

Abstract

Whereas genetic factors contribute crucially to brain function, early-life events, including stress, exert long-lasting influence on neuronal function. Here, we focus on the hippocampus as the target of these early-life events because of its crucial role in learning and memory. Using a novel immature-rodent model, we describe the deleterious consequences of chronic early-life 'psychological' stress on hippocampus-dependent cognitive tasks. We review the cellular mechanisms involved and discuss the roles of stress-mediating molecules, including corticotropin releasing hormone, in the process by which stress impacts the structure and function of hippocampal neurons.

Original language	English (US)
Pages (from-to)	180-192
Number of pages	13
Journal	Frontiers in Neuroendocrinology
Volume	27
Issue number	2
DOIs	https://doi.org/10.1016/j.yfrne.2006.02.001
State	Published - Jul 2006
Externally published	Yes

All Science Journal Classification (ASJC) codes

Endocrine and Autonomic Systems

Access to Document

10.1016/j.yfrne.2006.02.001

Fingerprint Dive into the research topics of 'Hippocampal neuroplasticity induced by early-life stress: Functional and molecular aspects'. Together they form a unique fingerprint.

Cite this

@article{afe2071d954e49c9b6c352e1a7e82a2d,

title = "Hippocampal neuroplasticity induced by early-life stress: Functional and molecular aspects",

abstract = "Whereas genetic factors contribute crucially to brain function, early-life events, including stress, exert long-lasting influence on neuronal function. Here, we focus on the hippocampus as the target of these early-life events because of its crucial role in learning and memory. Using a novel immature-rodent model, we describe the deleterious consequences of chronic early-life 'psychological' stress on hippocampus-dependent cognitive tasks. We review the cellular mechanisms involved and discuss the roles of stress-mediating molecules, including corticotropin releasing hormone, in the process by which stress impacts the structure and function of hippocampal neurons.",

author = "Fenoglio, {Kristina A.} and Brunson, {Kristen L.} and Baram, {Tallie Z.}",

note = "Funding Information: The authors thank Michele Hinojosa for excellent editorial assistance. Authors{\textquoteright} research is supported by National Institutes of Health Grants NS39307/MH 73136 and NS28912. ",

year = "2006",

month = jul,

doi = "10.1016/j.yfrne.2006.02.001",

language = "English (US)",

volume = "27",

pages = "180--192",

journal = "Frontiers in Neuroendocrinology",

issn = "0091-3022",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - Hippocampal neuroplasticity induced by early-life stress

T2 - Functional and molecular aspects

AU - Fenoglio, Kristina A.

AU - Brunson, Kristen L.

AU - Baram, Tallie Z.

N1 - Funding Information: The authors thank Michele Hinojosa for excellent editorial assistance. Authors’ research is supported by National Institutes of Health Grants NS39307/MH 73136 and NS28912.

PY - 2006/7

Y1 - 2006/7

N2 - Whereas genetic factors contribute crucially to brain function, early-life events, including stress, exert long-lasting influence on neuronal function. Here, we focus on the hippocampus as the target of these early-life events because of its crucial role in learning and memory. Using a novel immature-rodent model, we describe the deleterious consequences of chronic early-life 'psychological' stress on hippocampus-dependent cognitive tasks. We review the cellular mechanisms involved and discuss the roles of stress-mediating molecules, including corticotropin releasing hormone, in the process by which stress impacts the structure and function of hippocampal neurons.

AB - Whereas genetic factors contribute crucially to brain function, early-life events, including stress, exert long-lasting influence on neuronal function. Here, we focus on the hippocampus as the target of these early-life events because of its crucial role in learning and memory. Using a novel immature-rodent model, we describe the deleterious consequences of chronic early-life 'psychological' stress on hippocampus-dependent cognitive tasks. We review the cellular mechanisms involved and discuss the roles of stress-mediating molecules, including corticotropin releasing hormone, in the process by which stress impacts the structure and function of hippocampal neurons.

UR - http://www.scopus.com/inward/record.url?scp=33745345179&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745345179&partnerID=8YFLogxK

U2 - 10.1016/j.yfrne.2006.02.001

DO - 10.1016/j.yfrne.2006.02.001

M3 - Review article

C2 - 16603235

AN - SCOPUS:33745345179

VL - 27

SP - 180

EP - 192

JO - Frontiers in Neuroendocrinology

JF - Frontiers in Neuroendocrinology

SN - 0091-3022

IS - 2

ER -