TY - JOUR
T1 - Hippocampal neuroplasticity induced by early-life stress
T2 - Functional and molecular aspects
AU - Fenoglio, Kristina A.
AU - Brunson, Kristen L.
AU - Baram, Tallie Z.
N1 - Funding Information:
The authors thank Michele Hinojosa for excellent editorial assistance. Authors’ research is supported by National Institutes of Health Grants NS39307/MH 73136 and NS28912.
PY - 2006/7
Y1 - 2006/7
N2 - Whereas genetic factors contribute crucially to brain function, early-life events, including stress, exert long-lasting influence on neuronal function. Here, we focus on the hippocampus as the target of these early-life events because of its crucial role in learning and memory. Using a novel immature-rodent model, we describe the deleterious consequences of chronic early-life 'psychological' stress on hippocampus-dependent cognitive tasks. We review the cellular mechanisms involved and discuss the roles of stress-mediating molecules, including corticotropin releasing hormone, in the process by which stress impacts the structure and function of hippocampal neurons.
AB - Whereas genetic factors contribute crucially to brain function, early-life events, including stress, exert long-lasting influence on neuronal function. Here, we focus on the hippocampus as the target of these early-life events because of its crucial role in learning and memory. Using a novel immature-rodent model, we describe the deleterious consequences of chronic early-life 'psychological' stress on hippocampus-dependent cognitive tasks. We review the cellular mechanisms involved and discuss the roles of stress-mediating molecules, including corticotropin releasing hormone, in the process by which stress impacts the structure and function of hippocampal neurons.
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U2 - 10.1016/j.yfrne.2006.02.001
DO - 10.1016/j.yfrne.2006.02.001
M3 - Review article
C2 - 16603235
AN - SCOPUS:33745345179
VL - 27
SP - 180
EP - 192
JO - Frontiers in Neuroendocrinology
JF - Frontiers in Neuroendocrinology
SN - 0091-3022
IS - 2
ER -