Hippocampal neuroplasticity induced by early-life stress: Functional and molecular aspects

Kristina A. Fenoglio, Kristen L. Brunson, Tallie Z. Baram

Research output: Contribution to journalReview article

149 Scopus citations

Abstract

Whereas genetic factors contribute crucially to brain function, early-life events, including stress, exert long-lasting influence on neuronal function. Here, we focus on the hippocampus as the target of these early-life events because of its crucial role in learning and memory. Using a novel immature-rodent model, we describe the deleterious consequences of chronic early-life 'psychological' stress on hippocampus-dependent cognitive tasks. We review the cellular mechanisms involved and discuss the roles of stress-mediating molecules, including corticotropin releasing hormone, in the process by which stress impacts the structure and function of hippocampal neurons.

Original languageEnglish (US)
Pages (from-to)180-192
Number of pages13
JournalFrontiers in Neuroendocrinology
Volume27
Issue number2
DOIs
StatePublished - Jul 1 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Endocrine and Autonomic Systems

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