Abstract
Whereas genetic factors contribute crucially to brain function, early-life events, including stress, exert long-lasting influence on neuronal function. Here, we focus on the hippocampus as the target of these early-life events because of its crucial role in learning and memory. Using a novel immature-rodent model, we describe the deleterious consequences of chronic early-life 'psychological' stress on hippocampus-dependent cognitive tasks. We review the cellular mechanisms involved and discuss the roles of stress-mediating molecules, including corticotropin releasing hormone, in the process by which stress impacts the structure and function of hippocampal neurons.
| Original language | English |
|---|---|
| Pages (from-to) | 180-192 |
| Number of pages | 13 |
| Journal | Frontiers in Neuroendocrinology |
| Volume | 27 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jul 2006 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Endocrinology, Diabetes and Metabolism
- Endocrine and Autonomic Systems
Cite this
Hippocampal neuroplasticity induced by early-life stress : Functional and molecular aspects. / Simeone, Kristina A.; Brunson, Kristen L.; Baram, Tallie Z.
In: Frontiers in Neuroendocrinology, Vol. 27, No. 2, 07.2006, p. 180-192.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Hippocampal neuroplasticity induced by early-life stress
T2 - Functional and molecular aspects
AU - Simeone, Kristina A.
AU - Brunson, Kristen L.
AU - Baram, Tallie Z.
PY - 2006/7
Y1 - 2006/7
N2 - Whereas genetic factors contribute crucially to brain function, early-life events, including stress, exert long-lasting influence on neuronal function. Here, we focus on the hippocampus as the target of these early-life events because of its crucial role in learning and memory. Using a novel immature-rodent model, we describe the deleterious consequences of chronic early-life 'psychological' stress on hippocampus-dependent cognitive tasks. We review the cellular mechanisms involved and discuss the roles of stress-mediating molecules, including corticotropin releasing hormone, in the process by which stress impacts the structure and function of hippocampal neurons.
AB - Whereas genetic factors contribute crucially to brain function, early-life events, including stress, exert long-lasting influence on neuronal function. Here, we focus on the hippocampus as the target of these early-life events because of its crucial role in learning and memory. Using a novel immature-rodent model, we describe the deleterious consequences of chronic early-life 'psychological' stress on hippocampus-dependent cognitive tasks. We review the cellular mechanisms involved and discuss the roles of stress-mediating molecules, including corticotropin releasing hormone, in the process by which stress impacts the structure and function of hippocampal neurons.
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UR - http://www.scopus.com/inward/citedby.url?scp=33745345179&partnerID=8YFLogxK
U2 - 10.1016/j.yfrne.2006.02.001
DO - 10.1016/j.yfrne.2006.02.001
M3 - Review article
VL - 27
SP - 180
EP - 192
JO - Frontiers in Neuroendocrinology
JF - Frontiers in Neuroendocrinology
SN - 0091-3022
IS - 2
ER -