Hippocampal neuroplasticity induced by early-life stress

Functional and molecular aspects

Kristina A. Simeone, Kristen L. Brunson, Tallie Z. Baram

Research output: Contribution to journalReview article

137 Citations (Scopus)

Abstract

Whereas genetic factors contribute crucially to brain function, early-life events, including stress, exert long-lasting influence on neuronal function. Here, we focus on the hippocampus as the target of these early-life events because of its crucial role in learning and memory. Using a novel immature-rodent model, we describe the deleterious consequences of chronic early-life 'psychological' stress on hippocampus-dependent cognitive tasks. We review the cellular mechanisms involved and discuss the roles of stress-mediating molecules, including corticotropin releasing hormone, in the process by which stress impacts the structure and function of hippocampal neurons.

Original languageEnglish
Pages (from-to)180-192
Number of pages13
JournalFrontiers in Neuroendocrinology
Volume27
Issue number2
DOIs
StatePublished - Jul 2006
Externally publishedYes

Fingerprint

Neuronal Plasticity
Psychological Stress
Hippocampus
Corticotropin-Releasing Hormone
Rodentia
Learning
Neurons
Brain

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrine and Autonomic Systems

Cite this

Hippocampal neuroplasticity induced by early-life stress : Functional and molecular aspects. / Simeone, Kristina A.; Brunson, Kristen L.; Baram, Tallie Z.

In: Frontiers in Neuroendocrinology, Vol. 27, No. 2, 07.2006, p. 180-192.

Research output: Contribution to journalReview article

@article{afe2071d954e49c9b6c352e1a7e82a2d,
title = "Hippocampal neuroplasticity induced by early-life stress: Functional and molecular aspects",
abstract = "Whereas genetic factors contribute crucially to brain function, early-life events, including stress, exert long-lasting influence on neuronal function. Here, we focus on the hippocampus as the target of these early-life events because of its crucial role in learning and memory. Using a novel immature-rodent model, we describe the deleterious consequences of chronic early-life 'psychological' stress on hippocampus-dependent cognitive tasks. We review the cellular mechanisms involved and discuss the roles of stress-mediating molecules, including corticotropin releasing hormone, in the process by which stress impacts the structure and function of hippocampal neurons.",
author = "Simeone, {Kristina A.} and Brunson, {Kristen L.} and Baram, {Tallie Z.}",
year = "2006",
month = "7",
doi = "10.1016/j.yfrne.2006.02.001",
language = "English",
volume = "27",
pages = "180--192",
journal = "Frontiers in Neuroendocrinology",
issn = "0091-3022",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Hippocampal neuroplasticity induced by early-life stress

T2 - Functional and molecular aspects

AU - Simeone, Kristina A.

AU - Brunson, Kristen L.

AU - Baram, Tallie Z.

PY - 2006/7

Y1 - 2006/7

N2 - Whereas genetic factors contribute crucially to brain function, early-life events, including stress, exert long-lasting influence on neuronal function. Here, we focus on the hippocampus as the target of these early-life events because of its crucial role in learning and memory. Using a novel immature-rodent model, we describe the deleterious consequences of chronic early-life 'psychological' stress on hippocampus-dependent cognitive tasks. We review the cellular mechanisms involved and discuss the roles of stress-mediating molecules, including corticotropin releasing hormone, in the process by which stress impacts the structure and function of hippocampal neurons.

AB - Whereas genetic factors contribute crucially to brain function, early-life events, including stress, exert long-lasting influence on neuronal function. Here, we focus on the hippocampus as the target of these early-life events because of its crucial role in learning and memory. Using a novel immature-rodent model, we describe the deleterious consequences of chronic early-life 'psychological' stress on hippocampus-dependent cognitive tasks. We review the cellular mechanisms involved and discuss the roles of stress-mediating molecules, including corticotropin releasing hormone, in the process by which stress impacts the structure and function of hippocampal neurons.

UR - http://www.scopus.com/inward/record.url?scp=33745345179&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745345179&partnerID=8YFLogxK

U2 - 10.1016/j.yfrne.2006.02.001

DO - 10.1016/j.yfrne.2006.02.001

M3 - Review article

VL - 27

SP - 180

EP - 192

JO - Frontiers in Neuroendocrinology

JF - Frontiers in Neuroendocrinology

SN - 0091-3022

IS - 2

ER -