Historical development of Lynch syndrome

Henry T. Lynch; Stephen J. Lanspa; Carrie L. Snyder; Trudy G. Shaw; Patrick M. Lynch

doi:10.1007/978-94-007-6597-9_1

Historical development of Lynch syndrome

Henry T. Lynch, Stephen J. Lanspa, Carrie L. Snyder, Trudy G. Shaw, Patrick M. Lynch

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

One hundred years have passed since Aldred Warthin published the first report of a family with the combination of nonpolyposis colorectal cancer and extracolonic cancers that is now recognized as Lynch syndrome. His work from 1913 was rediscovered in the 1960s, when more families with the syndrome, then called cancer family syndrome, were recognized. In the 1990s, causal mutations were identified in mismatch repair genes; this led to greater scientific acceptance of the disorder, as well as to the ability to determine which family members were at increased cancer risk and thereby in need of rigorous surveillance and management strategies. Since that time, our knowledge of the syndrome, albeit still incomplete, has continued to increase. However, a great deal of work still needs to be done in order to realize the potential of translation of this knowledge to clinical use.

Original language	English (US)
Title of host publication	DNA Alterations in Lynch Syndrome
Subtitle of host publication	Advances in Molecular Diagnosis and Genetic Counselling
Publisher	Springer Netherlands
Pages	1-24
Number of pages	24
ISBN (Electronic)	9789400765979
ISBN (Print)	9400765967, 9789400765962
DOIs	https://doi.org/10.1007/978-94-007-6597-9_1
State	Published - Feb 1 2013

All Science Journal Classification (ASJC) codes

Medicine(all)

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abstract = "One hundred years have passed since Aldred Warthin published the first report of a family with the combination of nonpolyposis colorectal cancer and extracolonic cancers that is now recognized as Lynch syndrome. His work from 1913 was rediscovered in the 1960s, when more families with the syndrome, then called cancer family syndrome, were recognized. In the 1990s, causal mutations were identified in mismatch repair genes; this led to greater scientific acceptance of the disorder, as well as to the ability to determine which family members were at increased cancer risk and thereby in need of rigorous surveillance and management strategies. Since that time, our knowledge of the syndrome, albeit still incomplete, has continued to increase. However, a great deal of work still needs to be done in order to realize the potential of translation of this knowledge to clinical use.",

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Historical development of Lynch syndrome

Abstract

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