Historical development of Lynch syndrome

Henry T. Lynch, Stephen J. Lanspa, Carrie L. Snyder, Trudy G. Shaw, Patrick M. Lynch

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

One hundred years have passed since Aldred Warthin published the first report of a family with the combination of nonpolyposis colorectal cancer and extracolonic cancers that is now recognized as Lynch syndrome. His work from 1913 was rediscovered in the 1960s, when more families with the syndrome, then called cancer family syndrome, were recognized. In the 1990s, causal mutations were identified in mismatch repair genes; this led to greater scientific acceptance of the disorder, as well as to the ability to determine which family members were at increased cancer risk and thereby in need of rigorous surveillance and management strategies. Since that time, our knowledge of the syndrome, albeit still incomplete, has continued to increase. However, a great deal of work still needs to be done in order to realize the potential of translation of this knowledge to clinical use.

Original languageEnglish
Title of host publicationDNA Alterations in Lynch Syndrome: Advances in Molecular Diagnosis and Genetic Counselling
PublisherSpringer Netherlands
Pages1-24
Number of pages24
ISBN (Electronic)9789400765979
ISBN (Print)9400765967, 9789400765962
DOIs
StatePublished - Feb 1 2013

Fingerprint

Hereditary Nonpolyposis Colorectal Neoplasms
Neoplasms
DNA Mismatch Repair
Aptitude
Translational Medical Research
Colorectal Neoplasms
Mutation
Genes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Lynch, H. T., Lanspa, S. J., Snyder, C. L., Shaw, T. G., & Lynch, P. M. (2013). Historical development of Lynch syndrome. In DNA Alterations in Lynch Syndrome: Advances in Molecular Diagnosis and Genetic Counselling (pp. 1-24). Springer Netherlands. https://doi.org/10.1007/978-94-007-6597-9_1

Historical development of Lynch syndrome. / Lynch, Henry T.; Lanspa, Stephen J.; Snyder, Carrie L.; Shaw, Trudy G.; Lynch, Patrick M.

DNA Alterations in Lynch Syndrome: Advances in Molecular Diagnosis and Genetic Counselling. Springer Netherlands, 2013. p. 1-24.

Research output: Chapter in Book/Report/Conference proceedingChapter

Lynch, HT, Lanspa, SJ, Snyder, CL, Shaw, TG & Lynch, PM 2013, Historical development of Lynch syndrome. in DNA Alterations in Lynch Syndrome: Advances in Molecular Diagnosis and Genetic Counselling. Springer Netherlands, pp. 1-24. https://doi.org/10.1007/978-94-007-6597-9_1
Lynch HT, Lanspa SJ, Snyder CL, Shaw TG, Lynch PM. Historical development of Lynch syndrome. In DNA Alterations in Lynch Syndrome: Advances in Molecular Diagnosis and Genetic Counselling. Springer Netherlands. 2013. p. 1-24 https://doi.org/10.1007/978-94-007-6597-9_1
Lynch, Henry T. ; Lanspa, Stephen J. ; Snyder, Carrie L. ; Shaw, Trudy G. ; Lynch, Patrick M. / Historical development of Lynch syndrome. DNA Alterations in Lynch Syndrome: Advances in Molecular Diagnosis and Genetic Counselling. Springer Netherlands, 2013. pp. 1-24
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