Hl‐a in cancer family “n”

Henry T. Lynch; Robert J. Thomas; Paul I. Terasaki; Alan Ting; Hoda A. Guirgis; Arnold R. Kaplan; Hugh Magee; Jane Lynch; Carol Kraft; Edward Chaperon

doi:10.1002/1097-0142(197510)36:4<1315::AID-CNCR2820360419>3.0.CO;2-T

Hl‐a in cancer family “n”

Henry T. Lynch, Robert J. Thomas, Paul I. Terasaki, Alan Ting, Hoda A. Guirgis, Arnold R. Kaplan, Hugh Magee, Jane Lynch, Carol Kraft, Edward Chaperon

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Actual HL-A typing has been performed on 115 members of cancer family N, a large kindred (over 1,000 members ascertained) showing the findings consistent with the cancer family syndrome. In the cancer prone line (branches C and D) of the family, 20 of 21 members with cancer had 1 HL-A haplotype, HL-A2-HL-A12 (relative odds = 6.30), including some deceased family members who had haplotypes assigned. 11 Of 12 family members with cancer in branches C and D, actually typed, had HL-A2-HL-A12 (relative odds = 6.06). The single exception showing cancer and another haplotype in branch D is a child of a family member with haplotype HL-A2-HL-A12.

Original language	English (US)
Pages (from-to)	1315-1320
Number of pages	6
Journal	Cancer
Volume	36
Issue number	4
DOIs	https://doi.org/10.1002/1097-0142(197510)36:4<1315::AID-CNCR2820360419>3.0.CO;2-T
State	Published - Oct 1975
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1002/1097-0142(197510)36:4<1315::AID-CNCR2820360419>3.0.CO;2-T

Cite this

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title = "Hl‐a in cancer family “n”",

abstract = "Actual HL-A typing has been performed on 115 members of cancer family N, a large kindred (over 1,000 members ascertained) showing the findings consistent with the cancer family syndrome. In the cancer prone line (branches C and D) of the family, 20 of 21 members with cancer had 1 HL-A haplotype, HL-A2-HL-A12 (relative odds = 6.30), including some deceased family members who had haplotypes assigned. 11 Of 12 family members with cancer in branches C and D, actually typed, had HL-A2-HL-A12 (relative odds = 6.06). The single exception showing cancer and another haplotype in branch D is a child of a family member with haplotype HL-A2-HL-A12.",

author = "Lynch, {Henry T.} and Thomas, {Robert J.} and Terasaki, {Paul I.} and Alan Ting and Guirgis, {Hoda A.} and Kaplan, {Arnold R.} and Hugh Magee and Jane Lynch and Carol Kraft and Edward Chaperon",

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doi = "10.1002/1097-0142(197510)36:4<1315::AID-CNCR2820360419>3.0.CO;2-T",

language = "English (US)",

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publisher = "John Wiley and Sons Inc.",

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T1 - Hl‐a in cancer family “n”

AU - Lynch, Henry T.

AU - Thomas, Robert J.

AU - Terasaki, Paul I.

AU - Ting, Alan

AU - Guirgis, Hoda A.

AU - Kaplan, Arnold R.

AU - Magee, Hugh

AU - Lynch, Jane

AU - Kraft, Carol

AU - Chaperon, Edward

PY - 1975/10

Y1 - 1975/10

N2 - Actual HL-A typing has been performed on 115 members of cancer family N, a large kindred (over 1,000 members ascertained) showing the findings consistent with the cancer family syndrome. In the cancer prone line (branches C and D) of the family, 20 of 21 members with cancer had 1 HL-A haplotype, HL-A2-HL-A12 (relative odds = 6.30), including some deceased family members who had haplotypes assigned. 11 Of 12 family members with cancer in branches C and D, actually typed, had HL-A2-HL-A12 (relative odds = 6.06). The single exception showing cancer and another haplotype in branch D is a child of a family member with haplotype HL-A2-HL-A12.

AB - Actual HL-A typing has been performed on 115 members of cancer family N, a large kindred (over 1,000 members ascertained) showing the findings consistent with the cancer family syndrome. In the cancer prone line (branches C and D) of the family, 20 of 21 members with cancer had 1 HL-A haplotype, HL-A2-HL-A12 (relative odds = 6.30), including some deceased family members who had haplotypes assigned. 11 Of 12 family members with cancer in branches C and D, actually typed, had HL-A2-HL-A12 (relative odds = 6.06). The single exception showing cancer and another haplotype in branch D is a child of a family member with haplotype HL-A2-HL-A12.

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SN - 0008-543X

IS - 4

ER -

Hl‐a in cancer family “n”

Abstract

All Science Journal Classification (ASJC) codes

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