Actual HL-A typing has been performed on 115 members of cancer family N, a large kindred (over 1,000 members ascertained) showing the findings consistent with the cancer family syndrome. In the cancer prone line (branches C and D) of the family, 20 of 21 members with cancer had 1 HL-A haplotype, HL-A2-HL-A12 (relative odds = 6.30), including some deceased family members who had haplotypes assigned. 11 Of 12 family members with cancer in branches C and D, actually typed, had HL-A2-HL-A12 (relative odds = 6.06). The single exception showing cancer and another haplotype in branch D is a child of a family member with haplotype HL-A2-HL-A12.
|Original language||English (US)|
|Number of pages||6|
|State||Published - Oct 1975|
All Science Journal Classification (ASJC) codes
- Cancer Research