Hl‐a in cancer family “n”

Henry T. Lynch, Robert J. Thomas, Paul I. Terasaki, Alan Ting, Hoda A. Guirgis, Arnold R. Kaplan, Hugh Magee, Jane Lynch, Carol Kraft, Edward Chaperon

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Abstract

Actual HL-A typing has been performed on 115 members of cancer family N, a large kindred (over 1,000 members ascertained) showing the findings consistent with the cancer family syndrome. In the cancer prone line (branches C and D) of the family, 20 of 21 members with cancer had 1 HL-A haplotype, HL-A2-HL-A12 (relative odds = 6.30), including some deceased family members who had haplotypes assigned. 11 Of 12 family members with cancer in branches C and D, actually typed, had HL-A2-HL-A12 (relative odds = 6.06). The single exception showing cancer and another haplotype in branch D is a child of a family member with haplotype HL-A2-HL-A12.

Original languageEnglish (US)
Pages (from-to)1315-1320
Number of pages6
JournalCancer
Volume36
Issue number4
DOIs
StatePublished - Oct 1975

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Lynch, H. T., Thomas, R. J., Terasaki, P. I., Ting, A., Guirgis, H. A., Kaplan, A. R., Magee, H., Lynch, J., Kraft, C., & Chaperon, E. (1975). Hl‐a in cancer family “n”. Cancer, 36(4), 1315-1320. https://doi.org/10.1002/1097-0142(197510)36:4<1315::AID-CNCR2820360419>3.0.CO;2-T