Hl‐a in cancer family “n”

Henry T. Lynch; Robert J. Thomas; Paul I. Terasaki; Alan Ting; Hoda A. Guirgis; Arnold R. Kaplan; Hugh Magee; Jane Lynch; Carol Kraft; Edward Chaperon

doi:10.1002/1097-0142(197510)36:4<1315::AID-CNCR2820360419>3.0.CO;2-T

Hl‐a in cancer family “n”

Henry T. Lynch, Robert J. Thomas, Paul I. Terasaki, Alan Ting, Hoda A. Guirgis, Arnold R. Kaplan, Hugh Magee, Jane Lynch, Carol Kraft, Edward Chaperon

Department of Preventive Medicine

Research output: Contribution to journal › Article

21 Scopus citations

Abstract

Actual HL-A typing has been performed on 115 members of cancer family N, a large kindred (over 1,000 members ascertained) showing the findings consistent with the cancer family syndrome. In the cancer prone line (branches C and D) of the family, 20 of 21 members with cancer had 1 HL-A haplotype, HL-A2-HL-A12 (relative odds = 6.30), including some deceased family members who had haplotypes assigned. 11 Of 12 family members with cancer in branches C and D, actually typed, had HL-A2-HL-A12 (relative odds = 6.06). The single exception showing cancer and another haplotype in branch D is a child of a family member with haplotype HL-A2-HL-A12.

Original language	English (US)
Pages (from-to)	1315-1320
Number of pages	6
Journal	Cancer
Volume	36
Issue number	4
DOIs	https://doi.org/10.1002/1097-0142(197510)36:4<1315::AID-CNCR2820360419>3.0.CO;2-T
State	Published - Oct 1975

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All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

Cite this

Lynch, H. T., Thomas, R. J., Terasaki, P. I., Ting, A., Guirgis, H. A., Kaplan, A. R., Magee, H., Lynch, J., Kraft, C., & Chaperon, E. (1975). Hl‐a in cancer family “n”. Cancer, 36(4), 1315-1320. https://doi.org/10.1002/1097-0142(197510)36:4<1315::AID-CNCR2820360419>3.0.CO;2-T

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abstract = "Actual HL-A typing has been performed on 115 members of cancer family N, a large kindred (over 1,000 members ascertained) showing the findings consistent with the cancer family syndrome. In the cancer prone line (branches C and D) of the family, 20 of 21 members with cancer had 1 HL-A haplotype, HL-A2-HL-A12 (relative odds = 6.30), including some deceased family members who had haplotypes assigned. 11 Of 12 family members with cancer in branches C and D, actually typed, had HL-A2-HL-A12 (relative odds = 6.06). The single exception showing cancer and another haplotype in branch D is a child of a family member with haplotype HL-A2-HL-A12.",

author = "Lynch, {Henry T.} and Thomas, {Robert J.} and Terasaki, {Paul I.} and Alan Ting and Guirgis, {Hoda A.} and Kaplan, {Arnold R.} and Hugh Magee and Jane Lynch and Carol Kraft and Edward Chaperon",

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AU - Lynch, Henry T.

AU - Thomas, Robert J.

AU - Terasaki, Paul I.

AU - Ting, Alan

AU - Guirgis, Hoda A.

AU - Kaplan, Arnold R.

AU - Magee, Hugh

AU - Lynch, Jane

AU - Kraft, Carol

AU - Chaperon, Edward

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N2 - Actual HL-A typing has been performed on 115 members of cancer family N, a large kindred (over 1,000 members ascertained) showing the findings consistent with the cancer family syndrome. In the cancer prone line (branches C and D) of the family, 20 of 21 members with cancer had 1 HL-A haplotype, HL-A2-HL-A12 (relative odds = 6.30), including some deceased family members who had haplotypes assigned. 11 Of 12 family members with cancer in branches C and D, actually typed, had HL-A2-HL-A12 (relative odds = 6.06). The single exception showing cancer and another haplotype in branch D is a child of a family member with haplotype HL-A2-HL-A12.

AB - Actual HL-A typing has been performed on 115 members of cancer family N, a large kindred (over 1,000 members ascertained) showing the findings consistent with the cancer family syndrome. In the cancer prone line (branches C and D) of the family, 20 of 21 members with cancer had 1 HL-A haplotype, HL-A2-HL-A12 (relative odds = 6.30), including some deceased family members who had haplotypes assigned. 11 Of 12 family members with cancer in branches C and D, actually typed, had HL-A2-HL-A12 (relative odds = 6.06). The single exception showing cancer and another haplotype in branch D is a child of a family member with haplotype HL-A2-HL-A12.

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10.1002/1097-0142(197510)36:4<1315::AID-CNCR2820360419>3.0.CO;2-T