Homo- and hetero-oligomerization in the Slc26a protein family

Benjamin Currall, Heather Jensen-Smith, Richard Hallworth

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The motor-protein prestin is thought to be a homo-oligomer, but the oligomerization motifs are unknown. We used the acceptor-photobleach variant of fluorescence-lifetime based FRET analysis to demonstrate that homo-oligomerization is not only common to mammalian and non-mammalian prestins, but occurs in widely divergent members of the Slc26a family proteins. We therefore tested the hypothesis that oligomerization is conserved across the Slc26a family by measuring FRET between different Slc26a family molecules. Our results show that hetero-oligomerization is common between family members, which suggest that common oligomerization motifs exist.

Original languageEnglish (US)
Title of host publicationWhat Fire is in Mine Ears
Subtitle of host publicationProgress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop
Pages154-159
Number of pages6
DOIs
StatePublished - Dec 12 2011
Event11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics - Williamstown, MA, United States
Duration: Jul 16 2011Jul 22 2011

Publication series

NameAIP Conference Proceedings
Volume1403
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

Other11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics
CountryUnited States
CityWilliamstown, MA
Period7/16/117/22/11

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

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