Homo- and hetero-oligomerization in the Slc26a protein family

Benjamin Currall, Heather Jensen-Smith, Richard J. Hallworth

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The motor-protein prestin is thought to be a homo-oligomer, but the oligomerization motifs are unknown. We used the acceptor-photobleach variant of fluorescence-lifetime based FRET analysis to demonstrate that homo-oligomerization is not only common to mammalian and non-mammalian prestins, but occurs in widely divergent members of the Slc26a family proteins. We therefore tested the hypothesis that oligomerization is conserved across the Slc26a family by measuring FRET between different Slc26a family molecules. Our results show that hetero-oligomerization is common between family members, which suggest that common oligomerization motifs exist.

Original languageEnglish
Title of host publicationWhat Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop
Pages154-159
Number of pages6
Volume1403
DOIs
StatePublished - 2011
Event11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics - Williamstown, MA, United States
Duration: Jul 16 2011Jul 22 2011

Other

Other11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics
CountryUnited States
CityWilliamstown, MA
Period7/16/117/22/11

Fingerprint

proteins
oligomers
life (durability)
fluorescence
molecules

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

Cite this

Currall, B., Jensen-Smith, H., & Hallworth, R. J. (2011). Homo- and hetero-oligomerization in the Slc26a protein family. In What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop (Vol. 1403, pp. 154-159) https://doi.org/10.1063/1.3658077

Homo- and hetero-oligomerization in the Slc26a protein family. / Currall, Benjamin; Jensen-Smith, Heather; Hallworth, Richard J.

What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop. Vol. 1403 2011. p. 154-159.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Currall, B, Jensen-Smith, H & Hallworth, RJ 2011, Homo- and hetero-oligomerization in the Slc26a protein family. in What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop. vol. 1403, pp. 154-159, 11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics, Williamstown, MA, United States, 7/16/11. https://doi.org/10.1063/1.3658077
Currall B, Jensen-Smith H, Hallworth RJ. Homo- and hetero-oligomerization in the Slc26a protein family. In What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop. Vol. 1403. 2011. p. 154-159 https://doi.org/10.1063/1.3658077
Currall, Benjamin ; Jensen-Smith, Heather ; Hallworth, Richard J. / Homo- and hetero-oligomerization in the Slc26a protein family. What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop. Vol. 1403 2011. pp. 154-159
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