Hormonal therapy in traumatic spinal cord injury

Parker E. Ludwig, Arun A. Patil, Andrea J. Chamczuk, Devendra K. Agrawal

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Traumatic spinal cord injuries are major health problems and the underlying pathophysiological events and treatment strategies are currently under investigation. In this article, we critically reviewed the literature investigating the effects of estrogen, progesterone, and human chorionic gonadotropin on spinal cord damage or preservation following traumatic spinal cord injury. The National Library of Medicine database was searched through December 2016 using PubMed for articles addressing the clinical relevance of the hormones to improve neural structural integrity following traumatic spinal cord injury. It was found that each of these hormones, through varied mechanisms, could serve to reduce the harmful effects associated with spinal cord injury, and could aid in restoring some function to the injured spinal cord in the animal models. The most striking effects were seen in the reduction of inflammation commonly linked to injury of the central nervous system. The effects of human chorionic gonadotropin administration following spinal cord injury have received far less attention than those of either estrogen or progesterone, and additional inquiry could be of general benefit. In this article, we discussed the outstanding questions and suggested future directions for further investigation.

Original languageEnglish (US)
Article numberAJTR0057123
Pages (from-to)3881-3895
Number of pages15
JournalAmerican Journal of Translational Research
Volume9
Issue number9
StatePublished - 2017

Fingerprint

Spinal Cord Injuries
Chorionic Gonadotropin
Progesterone
Spinal Cord
Estrogens
Hormones
National Library of Medicine (U.S.)
Therapeutics
PubMed
Central Nervous System
Animal Models
Neurology
Structural integrity
Medical problems
Databases
Inflammation
Medicine
Animals
Health
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Clinical Biochemistry
  • Cancer Research

Cite this

Ludwig, P. E., Patil, A. A., Chamczuk, A. J., & Agrawal, D. K. (2017). Hormonal therapy in traumatic spinal cord injury. American Journal of Translational Research, 9(9), 3881-3895. [AJTR0057123].

Hormonal therapy in traumatic spinal cord injury. / Ludwig, Parker E.; Patil, Arun A.; Chamczuk, Andrea J.; Agrawal, Devendra K.

In: American Journal of Translational Research, Vol. 9, No. 9, AJTR0057123, 2017, p. 3881-3895.

Research output: Contribution to journalReview article

Ludwig, PE, Patil, AA, Chamczuk, AJ & Agrawal, DK 2017, 'Hormonal therapy in traumatic spinal cord injury', American Journal of Translational Research, vol. 9, no. 9, AJTR0057123, pp. 3881-3895.
Ludwig PE, Patil AA, Chamczuk AJ, Agrawal DK. Hormonal therapy in traumatic spinal cord injury. American Journal of Translational Research. 2017;9(9):3881-3895. AJTR0057123.
Ludwig, Parker E. ; Patil, Arun A. ; Chamczuk, Andrea J. ; Agrawal, Devendra K. / Hormonal therapy in traumatic spinal cord injury. In: American Journal of Translational Research. 2017 ; Vol. 9, No. 9. pp. 3881-3895.
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