How to Select and Interpret Molecular Strain Typing Methods for Epidemiological Studies of Bacterial Infections

A Review for Healthcare Epidemiologists

Fred C. Tenover, Robert D. Arbeit, Richard V. Goering, Barbara E. Murray, David H. Persing, Michael A. Pfaller, Robert A. Weinstein

Research output: Contribution to journalArticle

389 Citations (Scopus)

Abstract

Strain typing is an integral part of epidemiological investigations of nosocomial infections. Methods for distinguishing among bacterial strains have improved dramatically over the last 5 years, due mainly to the introduction of molecular technology. Although not all molecular techniques are equally effective for typing all organisms, pulsed-field gel electrophoresis is the technique currently favored for most nosocomial pathogens. Criteria to aid epidemiologists in interpreting results have been published. Nucleic acid amplification-based typing methods also are applicable to many organisms and can be completed within a single day, but interpretive criteria still are under debate. Strain typing cannot be used to replace a sound epidemiological investigation, but serves as a useful adjunct to such investigations.

Original languageEnglish
Pages (from-to)426-439
Number of pages14
JournalInfection Control and Hospital Epidemiology
Volume18
Issue number6
StatePublished - Jun 1997

Fingerprint

Molecular Typing
Bacterial Infections
Epidemiologic Studies
Delivery of Health Care
Pulsed Field Gel Electrophoresis
Cross Infection
Nucleic Acids
Technology
Epidemiologists

All Science Journal Classification (ASJC) codes

  • Immunology
  • Microbiology (medical)

Cite this

How to Select and Interpret Molecular Strain Typing Methods for Epidemiological Studies of Bacterial Infections : A Review for Healthcare Epidemiologists. / Tenover, Fred C.; Arbeit, Robert D.; Goering, Richard V.; Murray, Barbara E.; Persing, David H.; Pfaller, Michael A.; Weinstein, Robert A.

In: Infection Control and Hospital Epidemiology, Vol. 18, No. 6, 06.1997, p. 426-439.

Research output: Contribution to journalArticle

Tenover, Fred C. ; Arbeit, Robert D. ; Goering, Richard V. ; Murray, Barbara E. ; Persing, David H. ; Pfaller, Michael A. ; Weinstein, Robert A. / How to Select and Interpret Molecular Strain Typing Methods for Epidemiological Studies of Bacterial Infections : A Review for Healthcare Epidemiologists. In: Infection Control and Hospital Epidemiology. 1997 ; Vol. 18, No. 6. pp. 426-439.
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