Human disease genes and their cloned mouse orthologs: Exploration of the FANTOM2 cDNA sequence data set

Lynn M. Schriml, David P. Hill, Judith A. Blake, Hidemasa Bono, Anthony Wynshaw-Boris, William J. Pavan, Brian Z. Ring, Kirk Beisel, Mitsutoshi Setou, Yoshihide Hayashizaki, Takahiro Arakawa, Piero Carninci, Jun Kawai, Yasushi Okazaki

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Abstract

The FANTOM2 cDNA sequence data set is an excellent model to demonstrate the power of large-scale cDNA sequencing, with the goal of providing a full-length transcript sequence for each mouse gene. This data set enhances the use of the mouse as a model for human disease. Here we identify mouse cDNA sequences in the FANTOM2 data set for a set of 67 human disease genes that as of May 2002 had no corresponding mouse cDNA annotated in the Mouse Genome Informatics (MGI) database. These 67 human disease genes include genes related to neurological and eye disorders and cancer. We also present a list of the human disease genes and their cloned mouse orthologs found in two public databases, LocusLink and MGI. Allelic variant and gene functional information available in MGI provides additional information relative to these mouse models, whereas computed sequence-based connections at NCBI support facile navigation through multiple genomes.

Original languageEnglish (US)
Pages (from-to)1496-1500
Number of pages5
JournalGenome Research
Volume13
Issue number6 B
DOIs
StatePublished - Jun 1 2003

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All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Schriml, L. M., Hill, D. P., Blake, J. A., Bono, H., Wynshaw-Boris, A., Pavan, W. J., Ring, B. Z., Beisel, K., Setou, M., Hayashizaki, Y., Arakawa, T., Carninci, P., Kawai, J., & Okazaki, Y. (2003). Human disease genes and their cloned mouse orthologs: Exploration of the FANTOM2 cDNA sequence data set. Genome Research, 13(6 B), 1496-1500. https://doi.org/10.1101/gr.979503