Human disease genes and their cloned mouse orthologs

Exploration of the FANTOM2 cDNA sequence data set

Lynn M. Schriml, David P. Hill, Judith A. Blake, Hidemasa Bono, Anthony Wynshaw-Boris, William J. Pavan, Brian Z. Ring, Kirk Beisel, Mitsutoshi Setou, Yoshihide Hayashizaki, Takahiro Arakawa, Piero Carninci, Jun Kawai, Yasushi Okazaki

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The FANTOM2 cDNA sequence data set is an excellent model to demonstrate the power of large-scale cDNA sequencing, with the goal of providing a full-length transcript sequence for each mouse gene. This data set enhances the use of the mouse as a model for human disease. Here we identify mouse cDNA sequences in the FANTOM2 data set for a set of 67 human disease genes that as of May 2002 had no corresponding mouse cDNA annotated in the Mouse Genome Informatics (MGI) database. These 67 human disease genes include genes related to neurological and eye disorders and cancer. We also present a list of the human disease genes and their cloned mouse orthologs found in two public databases, LocusLink and MGI. Allelic variant and gene functional information available in MGI provides additional information relative to these mouse models, whereas computed sequence-based connections at NCBI support facile navigation through multiple genomes.

Original languageEnglish
Pages (from-to)1496-1500
Number of pages5
JournalGenome Research
Volume13
Issue number6 B
DOIs
StatePublished - Jun 1 2003

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Complementary DNA
Genes
Informatics
Genome
Eye Neoplasms
Databases
Datasets
Nervous System Diseases

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Schriml, L. M., Hill, D. P., Blake, J. A., Bono, H., Wynshaw-Boris, A., Pavan, W. J., ... Okazaki, Y. (2003). Human disease genes and their cloned mouse orthologs: Exploration of the FANTOM2 cDNA sequence data set. Genome Research, 13(6 B), 1496-1500. https://doi.org/10.1101/gr.979503

Human disease genes and their cloned mouse orthologs : Exploration of the FANTOM2 cDNA sequence data set. / Schriml, Lynn M.; Hill, David P.; Blake, Judith A.; Bono, Hidemasa; Wynshaw-Boris, Anthony; Pavan, William J.; Ring, Brian Z.; Beisel, Kirk; Setou, Mitsutoshi; Hayashizaki, Yoshihide; Arakawa, Takahiro; Carninci, Piero; Kawai, Jun; Okazaki, Yasushi.

In: Genome Research, Vol. 13, No. 6 B, 01.06.2003, p. 1496-1500.

Research output: Contribution to journalArticle

Schriml, LM, Hill, DP, Blake, JA, Bono, H, Wynshaw-Boris, A, Pavan, WJ, Ring, BZ, Beisel, K, Setou, M, Hayashizaki, Y, Arakawa, T, Carninci, P, Kawai, J & Okazaki, Y 2003, 'Human disease genes and their cloned mouse orthologs: Exploration of the FANTOM2 cDNA sequence data set', Genome Research, vol. 13, no. 6 B, pp. 1496-1500. https://doi.org/10.1101/gr.979503
Schriml LM, Hill DP, Blake JA, Bono H, Wynshaw-Boris A, Pavan WJ et al. Human disease genes and their cloned mouse orthologs: Exploration of the FANTOM2 cDNA sequence data set. Genome Research. 2003 Jun 1;13(6 B):1496-1500. https://doi.org/10.1101/gr.979503
Schriml, Lynn M. ; Hill, David P. ; Blake, Judith A. ; Bono, Hidemasa ; Wynshaw-Boris, Anthony ; Pavan, William J. ; Ring, Brian Z. ; Beisel, Kirk ; Setou, Mitsutoshi ; Hayashizaki, Yoshihide ; Arakawa, Takahiro ; Carninci, Piero ; Kawai, Jun ; Okazaki, Yasushi. / Human disease genes and their cloned mouse orthologs : Exploration of the FANTOM2 cDNA sequence data set. In: Genome Research. 2003 ; Vol. 13, No. 6 B. pp. 1496-1500.
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