Abstract
Background: The cholecalciferol inputs required to achieve or maintain any given serum 25-hydroxycholecalciferol concentration are not known, particularly within ranges comparable to the probable physiologic supply of the vitamin. Objectives: The objectives were to establish the quantitative relation between steady state cholecalciferol input and the resulting serum 25-hydroxycholecalciferol concentration and to estimate the proportion of the daily requirement during winter that is met by cholecalciferol reserves in body tissue stores. Design: Cholecalciferol was administered daily in controlled oral doses labeled at 0, 25, 125, and 250 μg cholecalciferol for ≈20 wk during the winter to 67 men living in Omaha (41.2° N latitude). The time course of serum 25-hydroxycholecalciferol concentration was measured at intervals over the course of treatment. Results: From a mean baseline value of 70.3 nmol/L, equilibrium concentrations of serum 25-hydroxycholecalciferol changed during the winter months in direct proportion to the dose, with a slope of ≈0.70 nmol/L for each additional 1 μg cholecalciferol input. The calculated oral input required to sustain the serum 25-hydroxycholecalciferol concentration present before the study (ie, in the autumn) was 12.5 μg (500 IU)/d, whereas the total amount from all sources (supplement, food, tissue stores) needed to sustain the starting 25-hydroxycholecalciferol concentration was estimated at ≈96 μg (≈3800 IU)/ d. By difference, the tissue stores provided ≈78-82 μg/d. Conclusions: Healthy men seem to use 3000-5000 IU cholecalciferol/d, apparently meeting >80% of their winter cholecalciferol need with cutaneously synthesized accumulations from solar sources during the preceding summer months. Current recommended vitamin D inputs are inadequate to maintain serum 25-hydroxycholecalciferol concentration in the absence of substantial cutaneous production of vitamin D.
| Original language | English |
|---|---|
| Pages (from-to) | 204-210 |
| Number of pages | 7 |
| Journal | American Journal of Clinical Nutrition |
| Volume | 77 |
| Issue number | 1 |
| State | Published - Jan 1 2003 |
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All Science Journal Classification (ASJC) codes
- Medicine (miscellaneous)
- Food Science
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Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. / Heaney, Robert P.; Davies, K. Michael; Chen, Tai C.; Holick, Michael F.; Janet Barger-Lux, M.
In: American Journal of Clinical Nutrition, Vol. 77, No. 1, 01.01.2003, p. 204-210.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol
AU - Heaney, Robert P.
AU - Davies, K. Michael
AU - Chen, Tai C.
AU - Holick, Michael F.
AU - Janet Barger-Lux, M.
PY - 2003/1/1
Y1 - 2003/1/1
N2 - Background: The cholecalciferol inputs required to achieve or maintain any given serum 25-hydroxycholecalciferol concentration are not known, particularly within ranges comparable to the probable physiologic supply of the vitamin. Objectives: The objectives were to establish the quantitative relation between steady state cholecalciferol input and the resulting serum 25-hydroxycholecalciferol concentration and to estimate the proportion of the daily requirement during winter that is met by cholecalciferol reserves in body tissue stores. Design: Cholecalciferol was administered daily in controlled oral doses labeled at 0, 25, 125, and 250 μg cholecalciferol for ≈20 wk during the winter to 67 men living in Omaha (41.2° N latitude). The time course of serum 25-hydroxycholecalciferol concentration was measured at intervals over the course of treatment. Results: From a mean baseline value of 70.3 nmol/L, equilibrium concentrations of serum 25-hydroxycholecalciferol changed during the winter months in direct proportion to the dose, with a slope of ≈0.70 nmol/L for each additional 1 μg cholecalciferol input. The calculated oral input required to sustain the serum 25-hydroxycholecalciferol concentration present before the study (ie, in the autumn) was 12.5 μg (500 IU)/d, whereas the total amount from all sources (supplement, food, tissue stores) needed to sustain the starting 25-hydroxycholecalciferol concentration was estimated at ≈96 μg (≈3800 IU)/ d. By difference, the tissue stores provided ≈78-82 μg/d. Conclusions: Healthy men seem to use 3000-5000 IU cholecalciferol/d, apparently meeting >80% of their winter cholecalciferol need with cutaneously synthesized accumulations from solar sources during the preceding summer months. Current recommended vitamin D inputs are inadequate to maintain serum 25-hydroxycholecalciferol concentration in the absence of substantial cutaneous production of vitamin D.
AB - Background: The cholecalciferol inputs required to achieve or maintain any given serum 25-hydroxycholecalciferol concentration are not known, particularly within ranges comparable to the probable physiologic supply of the vitamin. Objectives: The objectives were to establish the quantitative relation between steady state cholecalciferol input and the resulting serum 25-hydroxycholecalciferol concentration and to estimate the proportion of the daily requirement during winter that is met by cholecalciferol reserves in body tissue stores. Design: Cholecalciferol was administered daily in controlled oral doses labeled at 0, 25, 125, and 250 μg cholecalciferol for ≈20 wk during the winter to 67 men living in Omaha (41.2° N latitude). The time course of serum 25-hydroxycholecalciferol concentration was measured at intervals over the course of treatment. Results: From a mean baseline value of 70.3 nmol/L, equilibrium concentrations of serum 25-hydroxycholecalciferol changed during the winter months in direct proportion to the dose, with a slope of ≈0.70 nmol/L for each additional 1 μg cholecalciferol input. The calculated oral input required to sustain the serum 25-hydroxycholecalciferol concentration present before the study (ie, in the autumn) was 12.5 μg (500 IU)/d, whereas the total amount from all sources (supplement, food, tissue stores) needed to sustain the starting 25-hydroxycholecalciferol concentration was estimated at ≈96 μg (≈3800 IU)/ d. By difference, the tissue stores provided ≈78-82 μg/d. Conclusions: Healthy men seem to use 3000-5000 IU cholecalciferol/d, apparently meeting >80% of their winter cholecalciferol need with cutaneously synthesized accumulations from solar sources during the preceding summer months. Current recommended vitamin D inputs are inadequate to maintain serum 25-hydroxycholecalciferol concentration in the absence of substantial cutaneous production of vitamin D.
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M3 - Article
C2 - 12499343
AN - SCOPUS:0037215304
VL - 77
SP - 204
EP - 210
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 1
ER -