Abstract
Hydroxymethylglutaryl coenzyme A inhibitors (statins) reduce mortality in coronary artery disease, heart failure and have been shown to have pleiotropic anti-arrhythmic effects. We performed a meta-analysis to assess the utility of statins in atrial fibrillation (AF) and ventricular tachyarrhythmia (VA). Systematic review of all studies from 1990 until 2006 identified fourteen good quality studies on statins and AF and five studies on statins and VA. Meta-analysis was performed using the random-effects model and the pooled risk ratio (RR) for AF was RR: 0.73 (95% CI: 0.62-0.86) and for long term VA was 0.64 (95% CI: 0.44-0.94). In the subgroup analysis that included only randomized studies, the pooled risk ratio (RR) using random effects model for AF was RR: 0.64 (95% CI: 0.37-1.14). In conclusion, statins decrease the incidence and recurrence of AF and VA, but additional randomized studies are required to confirm this pleiotropic effect of statins.
| Original language | English |
|---|---|
| Journal | Internet Journal of Cardiology |
| Volume | 6 |
| Issue number | 2 |
| State | Published - 2009 |
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All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
Cite this
Hydroxymethylglutaryl coenzyme A inhibitors (statins) and arrhythmias : Systematic review and meta-analysis. / Thambidorai, Senthil K.; Anand, Kishlay; Hee, Tom T.; Mooss, Aryan N.; Esterbrooks, Dennis J.; Mohiuddin, Syed M.
In: Internet Journal of Cardiology, Vol. 6, No. 2, 2009.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hydroxymethylglutaryl coenzyme A inhibitors (statins) and arrhythmias
T2 - Systematic review and meta-analysis
AU - Thambidorai, Senthil K.
AU - Anand, Kishlay
AU - Hee, Tom T.
AU - Mooss, Aryan N.
AU - Esterbrooks, Dennis J.
AU - Mohiuddin, Syed M.
PY - 2009
Y1 - 2009
N2 - Hydroxymethylglutaryl coenzyme A inhibitors (statins) reduce mortality in coronary artery disease, heart failure and have been shown to have pleiotropic anti-arrhythmic effects. We performed a meta-analysis to assess the utility of statins in atrial fibrillation (AF) and ventricular tachyarrhythmia (VA). Systematic review of all studies from 1990 until 2006 identified fourteen good quality studies on statins and AF and five studies on statins and VA. Meta-analysis was performed using the random-effects model and the pooled risk ratio (RR) for AF was RR: 0.73 (95% CI: 0.62-0.86) and for long term VA was 0.64 (95% CI: 0.44-0.94). In the subgroup analysis that included only randomized studies, the pooled risk ratio (RR) using random effects model for AF was RR: 0.64 (95% CI: 0.37-1.14). In conclusion, statins decrease the incidence and recurrence of AF and VA, but additional randomized studies are required to confirm this pleiotropic effect of statins.
AB - Hydroxymethylglutaryl coenzyme A inhibitors (statins) reduce mortality in coronary artery disease, heart failure and have been shown to have pleiotropic anti-arrhythmic effects. We performed a meta-analysis to assess the utility of statins in atrial fibrillation (AF) and ventricular tachyarrhythmia (VA). Systematic review of all studies from 1990 until 2006 identified fourteen good quality studies on statins and AF and five studies on statins and VA. Meta-analysis was performed using the random-effects model and the pooled risk ratio (RR) for AF was RR: 0.73 (95% CI: 0.62-0.86) and for long term VA was 0.64 (95% CI: 0.44-0.94). In the subgroup analysis that included only randomized studies, the pooled risk ratio (RR) using random effects model for AF was RR: 0.64 (95% CI: 0.37-1.14). In conclusion, statins decrease the incidence and recurrence of AF and VA, but additional randomized studies are required to confirm this pleiotropic effect of statins.
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M3 - Article
VL - 6
JO - Internet Journal of Cardiology
JF - Internet Journal of Cardiology
SN - 1528-834X
IS - 2
ER -