Hydroxymethylglutaryl coenzyme A inhibitors (statins) and arrhythmias: Systematic review and meta-analysis

Senthil K. Thambidorai, Kishlay Anand, Tom T. Hee, Aryan N. Mooss, Dennis J. Esterbrooks, Syed M. Mohiuddin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Hydroxymethylglutaryl coenzyme A inhibitors (statins) reduce mortality in coronary artery disease, heart failure and have been shown to have pleiotropic anti-arrhythmic effects. We performed a meta-analysis to assess the utility of statins in atrial fibrillation (AF) and ventricular tachyarrhythmia (VA). Systematic review of all studies from 1990 until 2006 identified fourteen good quality studies on statins and AF and five studies on statins and VA. Meta-analysis was performed using the random-effects model and the pooled risk ratio (RR) for AF was RR: 0.73 (95% CI: 0.62-0.86) and for long term VA was 0.64 (95% CI: 0.44-0.94). In the subgroup analysis that included only randomized studies, the pooled risk ratio (RR) using random effects model for AF was RR: 0.64 (95% CI: 0.37-1.14). In conclusion, statins decrease the incidence and recurrence of AF and VA, but additional randomized studies are required to confirm this pleiotropic effect of statins.

Original languageEnglish
JournalInternet Journal of Cardiology
Volume6
Issue number2
StatePublished - 2009

Fingerprint

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Meta-Analysis
Cardiac Arrhythmias
Atrial Fibrillation
Odds Ratio
Anti-Arrhythmia Agents
Tachycardia
Coronary Artery Disease
Heart Failure
Recurrence
Mortality
Incidence

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Hydroxymethylglutaryl coenzyme A inhibitors (statins) and arrhythmias : Systematic review and meta-analysis. / Thambidorai, Senthil K.; Anand, Kishlay; Hee, Tom T.; Mooss, Aryan N.; Esterbrooks, Dennis J.; Mohiuddin, Syed M.

In: Internet Journal of Cardiology, Vol. 6, No. 2, 2009.

Research output: Contribution to journalArticle

@article{762f507cab834331bb81def14e415150,
title = "Hydroxymethylglutaryl coenzyme A inhibitors (statins) and arrhythmias: Systematic review and meta-analysis",
abstract = "Hydroxymethylglutaryl coenzyme A inhibitors (statins) reduce mortality in coronary artery disease, heart failure and have been shown to have pleiotropic anti-arrhythmic effects. We performed a meta-analysis to assess the utility of statins in atrial fibrillation (AF) and ventricular tachyarrhythmia (VA). Systematic review of all studies from 1990 until 2006 identified fourteen good quality studies on statins and AF and five studies on statins and VA. Meta-analysis was performed using the random-effects model and the pooled risk ratio (RR) for AF was RR: 0.73 (95{\%} CI: 0.62-0.86) and for long term VA was 0.64 (95{\%} CI: 0.44-0.94). In the subgroup analysis that included only randomized studies, the pooled risk ratio (RR) using random effects model for AF was RR: 0.64 (95{\%} CI: 0.37-1.14). In conclusion, statins decrease the incidence and recurrence of AF and VA, but additional randomized studies are required to confirm this pleiotropic effect of statins.",
author = "Thambidorai, {Senthil K.} and Kishlay Anand and Hee, {Tom T.} and Mooss, {Aryan N.} and Esterbrooks, {Dennis J.} and Mohiuddin, {Syed M.}",
year = "2009",
language = "English",
volume = "6",
journal = "Internet Journal of Cardiology",
issn = "1528-834X",
publisher = "Internet Scientific Publications, LLC",
number = "2",

}

TY - JOUR

T1 - Hydroxymethylglutaryl coenzyme A inhibitors (statins) and arrhythmias

T2 - Systematic review and meta-analysis

AU - Thambidorai, Senthil K.

AU - Anand, Kishlay

AU - Hee, Tom T.

AU - Mooss, Aryan N.

AU - Esterbrooks, Dennis J.

AU - Mohiuddin, Syed M.

PY - 2009

Y1 - 2009

N2 - Hydroxymethylglutaryl coenzyme A inhibitors (statins) reduce mortality in coronary artery disease, heart failure and have been shown to have pleiotropic anti-arrhythmic effects. We performed a meta-analysis to assess the utility of statins in atrial fibrillation (AF) and ventricular tachyarrhythmia (VA). Systematic review of all studies from 1990 until 2006 identified fourteen good quality studies on statins and AF and five studies on statins and VA. Meta-analysis was performed using the random-effects model and the pooled risk ratio (RR) for AF was RR: 0.73 (95% CI: 0.62-0.86) and for long term VA was 0.64 (95% CI: 0.44-0.94). In the subgroup analysis that included only randomized studies, the pooled risk ratio (RR) using random effects model for AF was RR: 0.64 (95% CI: 0.37-1.14). In conclusion, statins decrease the incidence and recurrence of AF and VA, but additional randomized studies are required to confirm this pleiotropic effect of statins.

AB - Hydroxymethylglutaryl coenzyme A inhibitors (statins) reduce mortality in coronary artery disease, heart failure and have been shown to have pleiotropic anti-arrhythmic effects. We performed a meta-analysis to assess the utility of statins in atrial fibrillation (AF) and ventricular tachyarrhythmia (VA). Systematic review of all studies from 1990 until 2006 identified fourteen good quality studies on statins and AF and five studies on statins and VA. Meta-analysis was performed using the random-effects model and the pooled risk ratio (RR) for AF was RR: 0.73 (95% CI: 0.62-0.86) and for long term VA was 0.64 (95% CI: 0.44-0.94). In the subgroup analysis that included only randomized studies, the pooled risk ratio (RR) using random effects model for AF was RR: 0.64 (95% CI: 0.37-1.14). In conclusion, statins decrease the incidence and recurrence of AF and VA, but additional randomized studies are required to confirm this pleiotropic effect of statins.

UR - http://www.scopus.com/inward/record.url?scp=77953433922&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953433922&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:77953433922

VL - 6

JO - Internet Journal of Cardiology

JF - Internet Journal of Cardiology

SN - 1528-834X

IS - 2

ER -