Abstract
It is generally held that high insulin antibody concentrations, by 'buffering' abrupt swings in free insulin concentrations after injections of exogenous insulin, tend to stabilize blood glucose variations in diabetic patients. However, we encountered a patient with extremely labile diabetes coexisting with insulin resistance. This patient's injections were switched to pure porcine insulin from his usual mixed bovine/porcine insulin, in an effort to decrease his insulin requirement. This treatment was successful, and, as his insulin dosage decreased, his diabetic lability diminished substantially. His diabetes was eventually considered stabilized on about 22 units of porcine insulin daily. The serial decrease in his insulin antibody concentrations, monitored by use of solid-phase radioimmunoassay, paralleled the disappearance of his diabetic lability as well as the decrease in his insulin requirement.
| Original language | English |
|---|---|
| Pages (from-to) | 1463-1468 |
| Number of pages | 6 |
| Journal | Clinical Chemistry |
| Volume | 27 |
| Issue number | 8 |
| State | Published - 1981 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Clinical Biochemistry
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Hyperlabile Diabetes Accompanied by insulin resistance. / Renie, A.; Hamilton, R. G.; Adkinson, N. F.; Rendell, M. S.
In: Clinical Chemistry, Vol. 27, No. 8, 1981, p. 1463-1468.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hyperlabile Diabetes Accompanied by insulin resistance
AU - Renie, A.
AU - Hamilton, R. G.
AU - Adkinson, N. F.
AU - Rendell, M. S.
PY - 1981
Y1 - 1981
N2 - It is generally held that high insulin antibody concentrations, by 'buffering' abrupt swings in free insulin concentrations after injections of exogenous insulin, tend to stabilize blood glucose variations in diabetic patients. However, we encountered a patient with extremely labile diabetes coexisting with insulin resistance. This patient's injections were switched to pure porcine insulin from his usual mixed bovine/porcine insulin, in an effort to decrease his insulin requirement. This treatment was successful, and, as his insulin dosage decreased, his diabetic lability diminished substantially. His diabetes was eventually considered stabilized on about 22 units of porcine insulin daily. The serial decrease in his insulin antibody concentrations, monitored by use of solid-phase radioimmunoassay, paralleled the disappearance of his diabetic lability as well as the decrease in his insulin requirement.
AB - It is generally held that high insulin antibody concentrations, by 'buffering' abrupt swings in free insulin concentrations after injections of exogenous insulin, tend to stabilize blood glucose variations in diabetic patients. However, we encountered a patient with extremely labile diabetes coexisting with insulin resistance. This patient's injections were switched to pure porcine insulin from his usual mixed bovine/porcine insulin, in an effort to decrease his insulin requirement. This treatment was successful, and, as his insulin dosage decreased, his diabetic lability diminished substantially. His diabetes was eventually considered stabilized on about 22 units of porcine insulin daily. The serial decrease in his insulin antibody concentrations, monitored by use of solid-phase radioimmunoassay, paralleled the disappearance of his diabetic lability as well as the decrease in his insulin requirement.
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M3 - Article
VL - 27
SP - 1463
EP - 1468
JO - Clinical Chemistry
JF - Clinical Chemistry
SN - 0009-9147
IS - 8
ER -