Hyperlabile Diabetes Accompanied by insulin resistance

A. Renie, R. G. Hamilton, N. F. Adkinson, M. S. Rendell

Research output: Contribution to journalArticle

4 Scopus citations


It is generally held that high insulin antibody concentrations, by 'buffering' abrupt swings in free insulin concentrations after injections of exogenous insulin, tend to stabilize blood glucose variations in diabetic patients. However, we encountered a patient with extremely labile diabetes coexisting with insulin resistance. This patient's injections were switched to pure porcine insulin from his usual mixed bovine/porcine insulin, in an effort to decrease his insulin requirement. This treatment was successful, and, as his insulin dosage decreased, his diabetic lability diminished substantially. His diabetes was eventually considered stabilized on about 22 units of porcine insulin daily. The serial decrease in his insulin antibody concentrations, monitored by use of solid-phase radioimmunoassay, paralleled the disappearance of his diabetic lability as well as the decrease in his insulin requirement.

Original languageEnglish (US)
Pages (from-to)1463-1468
Number of pages6
JournalClinical Chemistry
Issue number8
StatePublished - Oct 26 1981


All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Renie, A., Hamilton, R. G., Adkinson, N. F., & Rendell, M. S. (1981). Hyperlabile Diabetes Accompanied by insulin resistance. Clinical Chemistry, 27(8), 1463-1468.