Hypocalciuria and abnormalities in mineral and skeletal homeostasis in patients with celiac sprue without intestinal symptoms

Susan M. Ott, Joseph R. Tucci, Robert P. Heaney, Stephen J. Marx

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Celiac sprue may be asymptomatic in terms of the gastrointestinal tract and, as a result, may go unrecognized for long periods of time. The objective of this report is to characterize patients who only show signs of abnormalities of mineral and skeletal homeostasis. We present data from six patients seen in academic clinics who eventually were diagnosed with celiac sprue. Serum and urine biochemical tests and bone density were measured. Results showed that the patients had variable initial presentations. Biochemical findings included hypocalciuria, hypocalcemia, low serum 25-OH vitamin D and carotene levels and increased serum parathyroid hormone (PTH) and 1,25-dihydroxyvitamin D [1,25(OH)2D] levels. Gluten-free diet resulted in clinical improvement. Low urine calcium was a consistent finding in these patients. We conclude that celiac sprue should be considered in patients with osteopenia or hypocalcemia, even in the absence of gastrointestinal signs or symptoms.

Original languageEnglish
Pages (from-to)201-206
Number of pages6
JournalEndocrinology and Metabolism
Volume4
Issue number3
StatePublished - 1997
Externally publishedYes

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Celiac Disease
Minerals
Homeostasis
Hypocalcemia
Serum
Urine
Gluten-Free Diet
Metabolic Bone Diseases
Carotenoids
Parathyroid Hormone
Vitamin D
Bone Density
Signs and Symptoms
Gastrointestinal Tract
Calcium

All Science Journal Classification (ASJC) codes

  • Endocrinology

Cite this

Hypocalciuria and abnormalities in mineral and skeletal homeostasis in patients with celiac sprue without intestinal symptoms. / Ott, Susan M.; Tucci, Joseph R.; Heaney, Robert P.; Marx, Stephen J.

In: Endocrinology and Metabolism, Vol. 4, No. 3, 1997, p. 201-206.

Research output: Contribution to journalArticle

Ott, Susan M. ; Tucci, Joseph R. ; Heaney, Robert P. ; Marx, Stephen J. / Hypocalciuria and abnormalities in mineral and skeletal homeostasis in patients with celiac sprue without intestinal symptoms. In: Endocrinology and Metabolism. 1997 ; Vol. 4, No. 3. pp. 201-206.
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