ICAM-1 is crucial for protection from TMEV-induced neuronal damage but not demyelination

Kristen M. Drescher, Laurie J. Zoecklein, Moses Rodriguez

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Previous work has suggested that the factors protecting mice from Theiler's murine encephalomyelitis virus (TMEV)-induced spinal cord demyelination are distinct from those involved in protection of the brain during the acute encephalitic phase. In this study, we examined the requirement for intercellular adhesion molecule-1 (ICAM-1) in both of these processes. During the acute phase of infection (days 7 to 10 after intracerebral infection with TMEV), no differences in brain or spinal cord pathology or virus burdens were observed between ICAM-1-knockout mice and the infected immunocompetent control mice of a similar background. Examination of brain pathology later in infection (that is, day 45 post infection [p.i.]) revealed that ICAM-1-deficient mice experienced increased levels of pathology in gray matter regions of the brain. We observed an increase in striatal damage and meningeal inflammation in the brains of TMEV-infected ICAM-1-knockout mice compared to C57BL/6J mice. Despite the increase in brain pathology, no immunoreactivity to viral antigens was detected, suggesting that the virus had been cleared by this time. Resistance to demyelination was similar in both groups, indicating that the resulting immune response was sufficient for protection of the spinal cord white matter.

Original languageEnglish
Pages (from-to)452-458
Number of pages7
JournalJournal of NeuroVirology
Volume8
Issue number5
DOIs
StatePublished - Oct 2002

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Theilovirus
Demyelinating Diseases
Intercellular Adhesion Molecule-1
Pathology
Brain
Spinal Cord
Infection
Knockout Mice
Viruses
Corpus Striatum
Viral Antigens
Encephalitis
Inbred C57BL Mouse

All Science Journal Classification (ASJC) codes

  • Virology
  • Clinical Neurology

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ICAM-1 is crucial for protection from TMEV-induced neuronal damage but not demyelination. / Drescher, Kristen M.; Zoecklein, Laurie J.; Rodriguez, Moses.

In: Journal of NeuroVirology, Vol. 8, No. 5, 10.2002, p. 452-458.

Research output: Contribution to journalArticle

Drescher, Kristen M. ; Zoecklein, Laurie J. ; Rodriguez, Moses. / ICAM-1 is crucial for protection from TMEV-induced neuronal damage but not demyelination. In: Journal of NeuroVirology. 2002 ; Vol. 8, No. 5. pp. 452-458.
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