Identification and characterization of linezolid-resistant cfr-positive staphylococcus aureus USA300 Isolates from a new york city medical center

Jeffrey B. Locke, Douglas E. Zuill, Caitlyn R. Scharn, Jennifer Deane, Daniel F. Sahm, Richard V. Goering, Stephen G. Jenkins, Karen J. Shaw

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The cfr gene was identified in three linezolid-resistant USA300 methicillin-resistant Staphylococcus aureus (MRSA) isolates collected over a 3-day period at a New York City medical center in 2011 as part of a routine surveillance program. Each isolate possessed a plasmid containing a pSCFS3-like cfr gene environment. Transformation of the cfr-bearing plasmids into the S. aureus ATCC 29213 background recapitulated the expected Cfr antibiogram, including resistance to linezolid, tiamulin, clindamycin, and florfenicol and susceptibility to tedizolid.

Original languageEnglish
Pages (from-to)6949-6952
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume58
Issue number11
DOIs
StatePublished - Nov 1 2014

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Linezolid
Staphylococcus aureus
Plasmids
Clindamycin
Microbial Sensitivity Tests
Methicillin-Resistant Staphylococcus aureus
Genes

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

Identification and characterization of linezolid-resistant cfr-positive staphylococcus aureus USA300 Isolates from a new york city medical center. / Locke, Jeffrey B.; Zuill, Douglas E.; Scharn, Caitlyn R.; Deane, Jennifer; Sahm, Daniel F.; Goering, Richard V.; Jenkins, Stephen G.; Shaw, Karen J.

In: Antimicrobial Agents and Chemotherapy, Vol. 58, No. 11, 01.11.2014, p. 6949-6952.

Research output: Contribution to journalArticle

Locke, Jeffrey B. ; Zuill, Douglas E. ; Scharn, Caitlyn R. ; Deane, Jennifer ; Sahm, Daniel F. ; Goering, Richard V. ; Jenkins, Stephen G. ; Shaw, Karen J. / Identification and characterization of linezolid-resistant cfr-positive staphylococcus aureus USA300 Isolates from a new york city medical center. In: Antimicrobial Agents and Chemotherapy. 2014 ; Vol. 58, No. 11. pp. 6949-6952.
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