Identification and characterization of linezolid-resistant cfr-positive staphylococcus aureus USA300 Isolates from a new york city medical center

Jeffrey B. Locke, Douglas E. Zuill, Caitlyn R. Scharn, Jennifer Deane, Daniel F. Sahm, Richard V. Goering, Stephen G. Jenkins, Karen J. Shaw

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Abstract

The cfr gene was identified in three linezolid-resistant USA300 methicillin-resistant Staphylococcus aureus (MRSA) isolates collected over a 3-day period at a New York City medical center in 2011 as part of a routine surveillance program. Each isolate possessed a plasmid containing a pSCFS3-like cfr gene environment. Transformation of the cfr-bearing plasmids into the S. aureus ATCC 29213 background recapitulated the expected Cfr antibiogram, including resistance to linezolid, tiamulin, clindamycin, and florfenicol and susceptibility to tedizolid.

Original languageEnglish (US)
Pages (from-to)6949-6952
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume58
Issue number11
DOIs
StatePublished - Nov 1 2014

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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