Identification and characterization of linezolid-resistant cfr-positive staphylococcus aureus USA300 Isolates from a new york city medical center

Jeffrey B. Locke; Douglas E. Zuill; Caitlyn R. Scharn; Jennifer Deane; Daniel F. Sahm; Richard V. Goering; Stephen G. Jenkins; Karen J. Shaw

doi:10.1128/AAC.03380-14

Identification and characterization of linezolid-resistant cfr-positive staphylococcus aureus USA300 Isolates from a new york city medical center

Jeffrey B. Locke, Douglas E. Zuill, Caitlyn R. Scharn, Jennifer Deane, Daniel F. Sahm, Richard V. Goering, Stephen G. Jenkins, Karen J. Shaw

Department of Medical Microbiology and Immunology

Research output: Contribution to journal › Article

14 Scopus citations

Abstract

The cfr gene was identified in three linezolid-resistant USA300 methicillin-resistant Staphylococcus aureus (MRSA) isolates collected over a 3-day period at a New York City medical center in 2011 as part of a routine surveillance program. Each isolate possessed a plasmid containing a pSCFS3-like cfr gene environment. Transformation of the cfr-bearing plasmids into the S. aureus ATCC 29213 background recapitulated the expected Cfr antibiogram, including resistance to linezolid, tiamulin, clindamycin, and florfenicol and susceptibility to tedizolid.

Original language	English (US)
Pages (from-to)	6949-6952
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	58
Issue number	11
DOIs	https://doi.org/10.1128/AAC.03380-14
State	Published - Nov 1 2014

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Locke, J. B., Zuill, D. E., Scharn, C. R., Deane, J., Sahm, D. F., Goering, R. V., Jenkins, S. G., & Shaw, K. J. (2014). Identification and characterization of linezolid-resistant cfr-positive staphylococcus aureus USA300 Isolates from a new york city medical center. Antimicrobial agents and chemotherapy, 58(11), 6949-6952. https://doi.org/10.1128/AAC.03380-14

Identification and characterization of linezolid-resistant cfr-positive staphylococcus aureus USA300 Isolates from a new york city medical center. / Locke, Jeffrey B.; Zuill, Douglas E.; Scharn, Caitlyn R.; Deane, Jennifer; Sahm, Daniel F.; Goering, Richard V.; Jenkins, Stephen G.; Shaw, Karen J.

In: Antimicrobial agents and chemotherapy, Vol. 58, No. 11, 01.11.2014, p. 6949-6952.

Research output: Contribution to journal › Article

Locke, Jeffrey B. ; Zuill, Douglas E. ; Scharn, Caitlyn R. ; Deane, Jennifer ; Sahm, Daniel F. ; Goering, Richard V. ; Jenkins, Stephen G. ; Shaw, Karen J. / Identification and characterization of linezolid-resistant cfr-positive staphylococcus aureus USA300 Isolates from a new york city medical center. In: Antimicrobial agents and chemotherapy. 2014 ; Vol. 58, No. 11. pp. 6949-6952.

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abstract = "The cfr gene was identified in three linezolid-resistant USA300 methicillin-resistant Staphylococcus aureus (MRSA) isolates collected over a 3-day period at a New York City medical center in 2011 as part of a routine surveillance program. Each isolate possessed a plasmid containing a pSCFS3-like cfr gene environment. Transformation of the cfr-bearing plasmids into the S. aureus ATCC 29213 background recapitulated the expected Cfr antibiogram, including resistance to linezolid, tiamulin, clindamycin, and florfenicol and susceptibility to tedizolid.",

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