Identification of a somatostatin-14-generating propeptide converting enzyme as a member of the kex2/furin/PC family

Robert Mackin, Bryan D. Noe, Joachim Spiess

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Abstract

A propeptide converting enzyme capable of producing somatostatin-14 has been identified and partially characterized from anglerfish pancreatic islets. Results from N-terminal protein sequence analysis indicate that this enzyme is a member of the kex2/furin/PC family. This observation provides strong corroborative evidence that the kex2/ furin/PC protease family is involved in propeptide conversion. Comparison of the obtained protein sequence with the cDNA sequence of mammalian PC2 also suggests that the active enzyme is derived from a precursor by cleavage at a site containing four consecutive basic amino acids.

Original languageEnglish
Pages (from-to)2263-2265
Number of pages3
JournalEndocrinology
Volume129
Issue number4
Publication statusPublished - Oct 1991
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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