Identification of calcium antagonist receptor binding sites using (3H)nitrendipine in bovine tracheal smooth muscle membranes

J. B. Cheng, A. Bewtra, R. G. Townley

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

(3H)Nitrendipine binding to the bovine tracheal muscle membrane at 25°C was rapid, saturable (Bmax=14.8±3.9fmol/mg protein) and of high affinity (Kd=0.15±0.04 nM). The rank order of Ca2+ antagonists competing for airway (3H)nitrendipine binding was nitrendipine {Mathematical expression} nisoldipine {Mathematical expression} nifedipine » verapamil. Cromolyn, however, neither inhibited nor increased the binding.

Original languageEnglish (US)
Pages (from-to)267-269
Number of pages3
JournalExperientia
Volume40
Issue number3
DOIs
StatePublished - Mar 1 1984

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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