Abstract
(3H)Nitrendipine binding to the bovine tracheal muscle membrane at 25°C was rapid, saturable (Bmax=14.8±3.9fmol/mg protein) and of high affinity (Kd=0.15±0.04 nM). The rank order of Ca2+ antagonists competing for airway (3H)nitrendipine binding was nitrendipine {Mathematical expression} nisoldipine {Mathematical expression} nifedipine » verapamil. Cromolyn, however, neither inhibited nor increased the binding.
| Original language | English |
|---|---|
| Pages (from-to) | 267-269 |
| Number of pages | 3 |
| Journal | Experientia |
| Volume | 40 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1984 |
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All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
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Identification of calcium antagonist receptor binding sites using (3H)nitrendipine in bovine tracheal smooth muscle membranes. / Cheng, J. B.; Bewtra, Againdra K.; Townley, R. G.
In: Experientia, Vol. 40, No. 3, 03.1984, p. 267-269.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Identification of calcium antagonist receptor binding sites using (3H)nitrendipine in bovine tracheal smooth muscle membranes
AU - Cheng, J. B.
AU - Bewtra, Againdra K.
AU - Townley, R. G.
PY - 1984/3
Y1 - 1984/3
N2 - (3H)Nitrendipine binding to the bovine tracheal muscle membrane at 25°C was rapid, saturable (Bmax=14.8±3.9fmol/mg protein) and of high affinity (Kd=0.15±0.04 nM). The rank order of Ca2+ antagonists competing for airway (3H)nitrendipine binding was nitrendipine {Mathematical expression} nisoldipine {Mathematical expression} nifedipine » verapamil. Cromolyn, however, neither inhibited nor increased the binding.
AB - (3H)Nitrendipine binding to the bovine tracheal muscle membrane at 25°C was rapid, saturable (Bmax=14.8±3.9fmol/mg protein) and of high affinity (Kd=0.15±0.04 nM). The rank order of Ca2+ antagonists competing for airway (3H)nitrendipine binding was nitrendipine {Mathematical expression} nisoldipine {Mathematical expression} nifedipine » verapamil. Cromolyn, however, neither inhibited nor increased the binding.
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U2 - 10.1007/BF01947575
DO - 10.1007/BF01947575
M3 - Article
VL - 40
SP - 267
EP - 269
JO - Cellular and Molecular Life Sciences
JF - Cellular and Molecular Life Sciences
SN - 1420-682X
IS - 3
ER -