Abstract
Pancreatic cancer-prone families provide a unique resource for studying the etiology, natural history, genetics, and treatment of pancreatic cancer. The only effective way of identifying these families is by obtaining a complete family history, since it is not possible to differentiate sporadic pancreatic cancer cases from hereditary cases based on either clinical presentation or features. These families also would benefit greatly from early detection or prevention strategies. Ultimately, this knowledge could be applied to the more common sporadic form of pancreatic cancer, where diagnosis is almost always late, and prognosis remains quite grim.
| Original language | English |
|---|---|
| Pages (from-to) | 907-918 |
| Number of pages | 12 |
| Journal | Gastroenterology Clinics of North America |
| Volume | 33 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 2004 |
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All Science Journal Classification (ASJC) codes
- Gastroenterology
Cite this
Identification of high-risk pancreatic cancer-prone families. / Brand, Randall E.; Lynch, Henry T.
In: Gastroenterology Clinics of North America, Vol. 33, No. 4, 12.2004, p. 907-918.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Identification of high-risk pancreatic cancer-prone families
AU - Brand, Randall E.
AU - Lynch, Henry T.
PY - 2004/12
Y1 - 2004/12
N2 - Pancreatic cancer-prone families provide a unique resource for studying the etiology, natural history, genetics, and treatment of pancreatic cancer. The only effective way of identifying these families is by obtaining a complete family history, since it is not possible to differentiate sporadic pancreatic cancer cases from hereditary cases based on either clinical presentation or features. These families also would benefit greatly from early detection or prevention strategies. Ultimately, this knowledge could be applied to the more common sporadic form of pancreatic cancer, where diagnosis is almost always late, and prognosis remains quite grim.
AB - Pancreatic cancer-prone families provide a unique resource for studying the etiology, natural history, genetics, and treatment of pancreatic cancer. The only effective way of identifying these families is by obtaining a complete family history, since it is not possible to differentiate sporadic pancreatic cancer cases from hereditary cases based on either clinical presentation or features. These families also would benefit greatly from early detection or prevention strategies. Ultimately, this knowledge could be applied to the more common sporadic form of pancreatic cancer, where diagnosis is almost always late, and prognosis remains quite grim.
UR - http://www.scopus.com/inward/record.url?scp=7444250155&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=7444250155&partnerID=8YFLogxK
U2 - 10.1016/j.gtc.2004.07.011
DO - 10.1016/j.gtc.2004.07.011
M3 - Article
C2 - 15528025
AN - SCOPUS:7444250155
VL - 33
SP - 907
EP - 918
JO - Gastroenterology Clinics of North America
JF - Gastroenterology Clinics of North America
SN - 0889-8553
IS - 4
ER -