Identification of individuals at risk for Lynch syndrome using targeted evaluations and genetic testing

National Society of Genetic Counselors and the Collaborative Group of the Americas on Inherited Colorectal Cancer joint practice guideline

Scott M. Weissman, Randall Burt, James Church, Steve Erdman, Heather Hampel, Spring Holter, Kory Jasperson, Matt F. Kalady, Joy Larsen Haidle, Henry T. Lynch, Selvi Palaniappan, Paul E. Wise, Leigha Senter

Research output: Contribution to journalReview article

76 Citations (Scopus)

Abstract

Identifying individuals who have Lynch syndrome (LS) involves a complex diagnostic work up that includes taking a detailed family history and a combination of various genetic and immunohistochemical tests. The National Society of Genetic Counselors (NSGC) and the Collaborative Group of the Americas on Inherited Colorectal Cancer (CGA-ICC) have come together to publish this clinical practice testing guideline for the evaluation of LS. The purpose of this practice guideline is to provide guidance and a testing algorithm for LS as well as recommendations on when to offer testing. This guideline does not replace a consultation with a genetics professional. This guideline includes explanations in support of this and a summary of background data. While this guideline is not intended to serve as a review of LS, it includes a discussion of background information on LS, and cites a number of key publications which should be reviewed for a more in-depth understanding of LS. These guidelines are intended for genetic counselors, geneticists, gastroenterolo-gists, surgeons, medical oncologists, obstetricians and gynecologists, nurses and other healthcare providers who evaluate patients for LS.

Original languageEnglish
Pages (from-to)484-493
Number of pages10
JournalJournal of Genetic Counseling
Volume21
Issue number4
DOIs
StatePublished - Aug 2012

Fingerprint

Hereditary Nonpolyposis Colorectal Neoplasms
Genetic Testing
Practice Guidelines
Colorectal Neoplasms
Joints
Guidelines
Counselors
Health Personnel
Publications
Referral and Consultation
Nurses

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)

Cite this

Identification of individuals at risk for Lynch syndrome using targeted evaluations and genetic testing : National Society of Genetic Counselors and the Collaborative Group of the Americas on Inherited Colorectal Cancer joint practice guideline. / Weissman, Scott M.; Burt, Randall; Church, James; Erdman, Steve; Hampel, Heather; Holter, Spring; Jasperson, Kory; Kalady, Matt F.; Haidle, Joy Larsen; Lynch, Henry T.; Palaniappan, Selvi; Wise, Paul E.; Senter, Leigha.

In: Journal of Genetic Counseling, Vol. 21, No. 4, 08.2012, p. 484-493.

Research output: Contribution to journalReview article

Weissman, Scott M. ; Burt, Randall ; Church, James ; Erdman, Steve ; Hampel, Heather ; Holter, Spring ; Jasperson, Kory ; Kalady, Matt F. ; Haidle, Joy Larsen ; Lynch, Henry T. ; Palaniappan, Selvi ; Wise, Paul E. ; Senter, Leigha. / Identification of individuals at risk for Lynch syndrome using targeted evaluations and genetic testing : National Society of Genetic Counselors and the Collaborative Group of the Americas on Inherited Colorectal Cancer joint practice guideline. In: Journal of Genetic Counseling. 2012 ; Vol. 21, No. 4. pp. 484-493.
@article{7631159f95084e5389ca1b1f6ff05925,
title = "Identification of individuals at risk for Lynch syndrome using targeted evaluations and genetic testing: National Society of Genetic Counselors and the Collaborative Group of the Americas on Inherited Colorectal Cancer joint practice guideline",
abstract = "Identifying individuals who have Lynch syndrome (LS) involves a complex diagnostic work up that includes taking a detailed family history and a combination of various genetic and immunohistochemical tests. The National Society of Genetic Counselors (NSGC) and the Collaborative Group of the Americas on Inherited Colorectal Cancer (CGA-ICC) have come together to publish this clinical practice testing guideline for the evaluation of LS. The purpose of this practice guideline is to provide guidance and a testing algorithm for LS as well as recommendations on when to offer testing. This guideline does not replace a consultation with a genetics professional. This guideline includes explanations in support of this and a summary of background data. While this guideline is not intended to serve as a review of LS, it includes a discussion of background information on LS, and cites a number of key publications which should be reviewed for a more in-depth understanding of LS. These guidelines are intended for genetic counselors, geneticists, gastroenterolo-gists, surgeons, medical oncologists, obstetricians and gynecologists, nurses and other healthcare providers who evaluate patients for LS.",
author = "Weissman, {Scott M.} and Randall Burt and James Church and Steve Erdman and Heather Hampel and Spring Holter and Kory Jasperson and Kalady, {Matt F.} and Haidle, {Joy Larsen} and Lynch, {Henry T.} and Selvi Palaniappan and Wise, {Paul E.} and Leigha Senter",
year = "2012",
month = "8",
doi = "10.1007/s10897-011-9465-7",
language = "English",
volume = "21",
pages = "484--493",
journal = "Journal of Genetic Counseling",
issn = "1059-7700",
publisher = "Kluwer Academic/Human Sciences Press Inc.",
number = "4",

}

TY - JOUR

T1 - Identification of individuals at risk for Lynch syndrome using targeted evaluations and genetic testing

T2 - National Society of Genetic Counselors and the Collaborative Group of the Americas on Inherited Colorectal Cancer joint practice guideline

AU - Weissman, Scott M.

AU - Burt, Randall

AU - Church, James

AU - Erdman, Steve

AU - Hampel, Heather

AU - Holter, Spring

AU - Jasperson, Kory

AU - Kalady, Matt F.

AU - Haidle, Joy Larsen

AU - Lynch, Henry T.

AU - Palaniappan, Selvi

AU - Wise, Paul E.

AU - Senter, Leigha

PY - 2012/8

Y1 - 2012/8

N2 - Identifying individuals who have Lynch syndrome (LS) involves a complex diagnostic work up that includes taking a detailed family history and a combination of various genetic and immunohistochemical tests. The National Society of Genetic Counselors (NSGC) and the Collaborative Group of the Americas on Inherited Colorectal Cancer (CGA-ICC) have come together to publish this clinical practice testing guideline for the evaluation of LS. The purpose of this practice guideline is to provide guidance and a testing algorithm for LS as well as recommendations on when to offer testing. This guideline does not replace a consultation with a genetics professional. This guideline includes explanations in support of this and a summary of background data. While this guideline is not intended to serve as a review of LS, it includes a discussion of background information on LS, and cites a number of key publications which should be reviewed for a more in-depth understanding of LS. These guidelines are intended for genetic counselors, geneticists, gastroenterolo-gists, surgeons, medical oncologists, obstetricians and gynecologists, nurses and other healthcare providers who evaluate patients for LS.

AB - Identifying individuals who have Lynch syndrome (LS) involves a complex diagnostic work up that includes taking a detailed family history and a combination of various genetic and immunohistochemical tests. The National Society of Genetic Counselors (NSGC) and the Collaborative Group of the Americas on Inherited Colorectal Cancer (CGA-ICC) have come together to publish this clinical practice testing guideline for the evaluation of LS. The purpose of this practice guideline is to provide guidance and a testing algorithm for LS as well as recommendations on when to offer testing. This guideline does not replace a consultation with a genetics professional. This guideline includes explanations in support of this and a summary of background data. While this guideline is not intended to serve as a review of LS, it includes a discussion of background information on LS, and cites a number of key publications which should be reviewed for a more in-depth understanding of LS. These guidelines are intended for genetic counselors, geneticists, gastroenterolo-gists, surgeons, medical oncologists, obstetricians and gynecologists, nurses and other healthcare providers who evaluate patients for LS.

UR - http://www.scopus.com/inward/record.url?scp=84863609627&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863609627&partnerID=8YFLogxK

U2 - 10.1007/s10897-011-9465-7

DO - 10.1007/s10897-011-9465-7

M3 - Review article

VL - 21

SP - 484

EP - 493

JO - Journal of Genetic Counseling

JF - Journal of Genetic Counseling

SN - 1059-7700

IS - 4

ER -