Identifying MicroRNAs involved in aging of the lateral wall of the cochlear duct

Qian Zhang, Huizhan Liu, Garrett Soukup, David Z. He

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Age-related hearing loss is a progressive sensorineural hearing loss that occurs during aging. Degeneration of the organ of Corti and atrophy of the lateral wall of the cochlear duct (or scala media) in the inner ear are the two primary causes. MicroRNAs (miRNAs), a class of short non-coding RNAs that regulate the expression of mRNA/protein targets, are important regulators of cellular senescence and aging. We examined miRNA gene expression profiles in the lateral wall of two mouse strains, along with exploration of the potential targets of those miRNAs that showed dynamic expression during aging. We show that 95 and 60 miRNAs exhibited differential expression in C57 and CBA mice during aging, respectively. A majority of downregulated miRNAs are known to regulate pathways of cell proliferation and differentiation, while all upregulated miRNAs are known regulators in the pro-apoptotic pathways. By using apoptosis-related gene array and bioinformatic approaches to predict miRNA targets, we identify candidate miRNA-regulated genes that regulate apoptosis pathways in the lateral wall of C57 and CBA mice during aging.

Original languageEnglish
Article number0112857
JournalPLoS One
Volume9
Issue number11
DOIs
StatePublished - Nov 18 2014

Fingerprint

Cochlear Duct
MicroRNAs
microRNA
Ducts
Aging of materials
Inbred CBA Mouse
Cell Aging
Audition
hearing
mice
apoptosis
Genes
Apoptosis
Organ of Corti
Untranslated RNA
Sensorineural Hearing Loss
Cell proliferation
Inner Ear
Bioinformatics
Computational Biology

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Identifying MicroRNAs involved in aging of the lateral wall of the cochlear duct. / Zhang, Qian; Liu, Huizhan; Soukup, Garrett; He, David Z.

In: PLoS One, Vol. 9, No. 11, 0112857, 18.11.2014.

Research output: Contribution to journalArticle

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