Abstract
PURPOSE: This study evaluates peptide tyrosine-tyrosine (PYY), intestinal transit, fecal retention time, and anal sphincter manometry in colectomized patients with ileal pouch-anal anastomosis. METHODS: Plasma and pouch PYY, mouth-to-pouch transit time, fecal retention time, and anal canal pressures were studied in 27 patients with ileoanal pouches a mean of 50 (range, 3-84) months after loop ileostomy closure. RESULTS: Basal and peak postprandial plasma PYY were significantly reduced in patients with pouches compared with controls (P <0.0001). Pouch PYY was decreased compared with control ileal PYY (P = 0.0003). No significant correlation was noted between intestinal transit and total integrated PYY response in patients with pouches (r = 0.36; P = 0.06). Fecal retention time was related to postprandial total integrated response of plasma PYY (r = 0.43; P = 0.02), mouth-to-pouch transit (r = 0.87; P <0.0001), and resting (r = 0.44; P = 0.02) and squeeze (r = 0.62; P = 0.0006) anal sphincter pressures. CONCLUSIONS: Colectomized ileoanal patients with pouches showed decreased plasma and pouch PYY compared with controls. Intestinal transit was not significantly related to PYY release. However, prolonged pouch fecal retention was associated with greater PYY release, mouth-to-pouch transit: and anal sphincter pressures.
| Original language | English |
|---|---|
| Pages (from-to) | 868-874 |
| Number of pages | 7 |
| Journal | Diseases of the Colon and Rectum |
| Volume | 41 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1998 |
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All Science Journal Classification (ASJC) codes
- Gastroenterology
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Ileoanal pouch function and release of peptide YY. / Ternent, Charles A.; Staab, Paul; Thorson, Alan G.; Blatchford, Garnet J.; Christensen, Mark A.; Thompson, Jon S.; Lanspa, Stephen J.; Meade, Paul G.; Cali, Rebecca A.; Falk, Peter M.; Sentovich, Stephen M.; Adrian, Thomas E.
In: Diseases of the Colon and Rectum, Vol. 41, No. 7, 07.1998, p. 868-874.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ileoanal pouch function and release of peptide YY
AU - Ternent, Charles A.
AU - Staab, Paul
AU - Thorson, Alan G.
AU - Blatchford, Garnet J.
AU - Christensen, Mark A.
AU - Thompson, Jon S.
AU - Lanspa, Stephen J.
AU - Meade, Paul G.
AU - Cali, Rebecca A.
AU - Falk, Peter M.
AU - Sentovich, Stephen M.
AU - Adrian, Thomas E.
PY - 1998/7
Y1 - 1998/7
N2 - PURPOSE: This study evaluates peptide tyrosine-tyrosine (PYY), intestinal transit, fecal retention time, and anal sphincter manometry in colectomized patients with ileal pouch-anal anastomosis. METHODS: Plasma and pouch PYY, mouth-to-pouch transit time, fecal retention time, and anal canal pressures were studied in 27 patients with ileoanal pouches a mean of 50 (range, 3-84) months after loop ileostomy closure. RESULTS: Basal and peak postprandial plasma PYY were significantly reduced in patients with pouches compared with controls (P <0.0001). Pouch PYY was decreased compared with control ileal PYY (P = 0.0003). No significant correlation was noted between intestinal transit and total integrated PYY response in patients with pouches (r = 0.36; P = 0.06). Fecal retention time was related to postprandial total integrated response of plasma PYY (r = 0.43; P = 0.02), mouth-to-pouch transit (r = 0.87; P <0.0001), and resting (r = 0.44; P = 0.02) and squeeze (r = 0.62; P = 0.0006) anal sphincter pressures. CONCLUSIONS: Colectomized ileoanal patients with pouches showed decreased plasma and pouch PYY compared with controls. Intestinal transit was not significantly related to PYY release. However, prolonged pouch fecal retention was associated with greater PYY release, mouth-to-pouch transit: and anal sphincter pressures.
AB - PURPOSE: This study evaluates peptide tyrosine-tyrosine (PYY), intestinal transit, fecal retention time, and anal sphincter manometry in colectomized patients with ileal pouch-anal anastomosis. METHODS: Plasma and pouch PYY, mouth-to-pouch transit time, fecal retention time, and anal canal pressures were studied in 27 patients with ileoanal pouches a mean of 50 (range, 3-84) months after loop ileostomy closure. RESULTS: Basal and peak postprandial plasma PYY were significantly reduced in patients with pouches compared with controls (P <0.0001). Pouch PYY was decreased compared with control ileal PYY (P = 0.0003). No significant correlation was noted between intestinal transit and total integrated PYY response in patients with pouches (r = 0.36; P = 0.06). Fecal retention time was related to postprandial total integrated response of plasma PYY (r = 0.43; P = 0.02), mouth-to-pouch transit (r = 0.87; P <0.0001), and resting (r = 0.44; P = 0.02) and squeeze (r = 0.62; P = 0.0006) anal sphincter pressures. CONCLUSIONS: Colectomized ileoanal patients with pouches showed decreased plasma and pouch PYY compared with controls. Intestinal transit was not significantly related to PYY release. However, prolonged pouch fecal retention was associated with greater PYY release, mouth-to-pouch transit: and anal sphincter pressures.
UR - http://www.scopus.com/inward/record.url?scp=0031845477&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031845477&partnerID=8YFLogxK
U2 - 10.1007/BF02235368
DO - 10.1007/BF02235368
M3 - Article
C2 - 9678372
AN - SCOPUS:0031845477
VL - 41
SP - 868
EP - 874
JO - Diseases of the Colon and Rectum
JF - Diseases of the Colon and Rectum
SN - 0012-3706
IS - 7
ER -