Ileoanal pouch function and release of peptide YY

Charles A. Ternent, Paul Staab, Alan G. Thorson, Garnet J. Blatchford, Mark A. Christensen, Jon S. Thompson, Stephen J. Lanspa, Paul G. Meade, Rebecca A. Cali, Peter M. Falk, Stephen M. Sentovich, Thomas E. Adrian

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

PURPOSE: This study evaluates peptide tyrosine-tyrosine (PYY), intestinal transit, fecal retention time, and anal sphincter manometry in colectomized patients with ileal pouch-anal anastomosis. METHODS: Plasma and pouch PYY, mouth-to-pouch transit time, fecal retention time, and anal canal pressures were studied in 27 patients with ileoanal pouches a mean of 50 (range, 3-84) months after loop ileostomy closure. RESULTS: Basal and peak postprandial plasma PYY were significantly reduced in patients with pouches compared with controls (P <0.0001). Pouch PYY was decreased compared with control ileal PYY (P = 0.0003). No significant correlation was noted between intestinal transit and total integrated PYY response in patients with pouches (r = 0.36; P = 0.06). Fecal retention time was related to postprandial total integrated response of plasma PYY (r = 0.43; P = 0.02), mouth-to-pouch transit (r = 0.87; P <0.0001), and resting (r = 0.44; P = 0.02) and squeeze (r = 0.62; P = 0.0006) anal sphincter pressures. CONCLUSIONS: Colectomized ileoanal patients with pouches showed decreased plasma and pouch PYY compared with controls. Intestinal transit was not significantly related to PYY release. However, prolonged pouch fecal retention was associated with greater PYY release, mouth-to-pouch transit: and anal sphincter pressures.

Original languageEnglish
Pages (from-to)868-874
Number of pages7
JournalDiseases of the Colon and Rectum
Volume41
Issue number7
DOIs
StatePublished - Jul 1998

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Peptide YY
Colonic Pouches
Anal Canal
Mouth
tyrosyltyrosine
Pressure
Ileostomy
Manometry

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Ternent, C. A., Staab, P., Thorson, A. G., Blatchford, G. J., Christensen, M. A., Thompson, J. S., ... Adrian, T. E. (1998). Ileoanal pouch function and release of peptide YY. Diseases of the Colon and Rectum, 41(7), 868-874. https://doi.org/10.1007/BF02235368

Ileoanal pouch function and release of peptide YY. / Ternent, Charles A.; Staab, Paul; Thorson, Alan G.; Blatchford, Garnet J.; Christensen, Mark A.; Thompson, Jon S.; Lanspa, Stephen J.; Meade, Paul G.; Cali, Rebecca A.; Falk, Peter M.; Sentovich, Stephen M.; Adrian, Thomas E.

In: Diseases of the Colon and Rectum, Vol. 41, No. 7, 07.1998, p. 868-874.

Research output: Contribution to journalArticle

Ternent, CA, Staab, P, Thorson, AG, Blatchford, GJ, Christensen, MA, Thompson, JS, Lanspa, SJ, Meade, PG, Cali, RA, Falk, PM, Sentovich, SM & Adrian, TE 1998, 'Ileoanal pouch function and release of peptide YY', Diseases of the Colon and Rectum, vol. 41, no. 7, pp. 868-874. https://doi.org/10.1007/BF02235368
Ternent CA, Staab P, Thorson AG, Blatchford GJ, Christensen MA, Thompson JS et al. Ileoanal pouch function and release of peptide YY. Diseases of the Colon and Rectum. 1998 Jul;41(7):868-874. https://doi.org/10.1007/BF02235368
Ternent, Charles A. ; Staab, Paul ; Thorson, Alan G. ; Blatchford, Garnet J. ; Christensen, Mark A. ; Thompson, Jon S. ; Lanspa, Stephen J. ; Meade, Paul G. ; Cali, Rebecca A. ; Falk, Peter M. ; Sentovich, Stephen M. ; Adrian, Thomas E. / Ileoanal pouch function and release of peptide YY. In: Diseases of the Colon and Rectum. 1998 ; Vol. 41, No. 7. pp. 868-874.
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abstract = "PURPOSE: This study evaluates peptide tyrosine-tyrosine (PYY), intestinal transit, fecal retention time, and anal sphincter manometry in colectomized patients with ileal pouch-anal anastomosis. METHODS: Plasma and pouch PYY, mouth-to-pouch transit time, fecal retention time, and anal canal pressures were studied in 27 patients with ileoanal pouches a mean of 50 (range, 3-84) months after loop ileostomy closure. RESULTS: Basal and peak postprandial plasma PYY were significantly reduced in patients with pouches compared with controls (P <0.0001). Pouch PYY was decreased compared with control ileal PYY (P = 0.0003). No significant correlation was noted between intestinal transit and total integrated PYY response in patients with pouches (r = 0.36; P = 0.06). Fecal retention time was related to postprandial total integrated response of plasma PYY (r = 0.43; P = 0.02), mouth-to-pouch transit (r = 0.87; P <0.0001), and resting (r = 0.44; P = 0.02) and squeeze (r = 0.62; P = 0.0006) anal sphincter pressures. CONCLUSIONS: Colectomized ileoanal patients with pouches showed decreased plasma and pouch PYY compared with controls. Intestinal transit was not significantly related to PYY release. However, prolonged pouch fecal retention was associated with greater PYY release, mouth-to-pouch transit: and anal sphincter pressures.",
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T1 - Ileoanal pouch function and release of peptide YY

AU - Ternent, Charles A.

AU - Staab, Paul

AU - Thorson, Alan G.

AU - Blatchford, Garnet J.

AU - Christensen, Mark A.

AU - Thompson, Jon S.

AU - Lanspa, Stephen J.

AU - Meade, Paul G.

AU - Cali, Rebecca A.

AU - Falk, Peter M.

AU - Sentovich, Stephen M.

AU - Adrian, Thomas E.

PY - 1998/7

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N2 - PURPOSE: This study evaluates peptide tyrosine-tyrosine (PYY), intestinal transit, fecal retention time, and anal sphincter manometry in colectomized patients with ileal pouch-anal anastomosis. METHODS: Plasma and pouch PYY, mouth-to-pouch transit time, fecal retention time, and anal canal pressures were studied in 27 patients with ileoanal pouches a mean of 50 (range, 3-84) months after loop ileostomy closure. RESULTS: Basal and peak postprandial plasma PYY were significantly reduced in patients with pouches compared with controls (P <0.0001). Pouch PYY was decreased compared with control ileal PYY (P = 0.0003). No significant correlation was noted between intestinal transit and total integrated PYY response in patients with pouches (r = 0.36; P = 0.06). Fecal retention time was related to postprandial total integrated response of plasma PYY (r = 0.43; P = 0.02), mouth-to-pouch transit (r = 0.87; P <0.0001), and resting (r = 0.44; P = 0.02) and squeeze (r = 0.62; P = 0.0006) anal sphincter pressures. CONCLUSIONS: Colectomized ileoanal patients with pouches showed decreased plasma and pouch PYY compared with controls. Intestinal transit was not significantly related to PYY release. However, prolonged pouch fecal retention was associated with greater PYY release, mouth-to-pouch transit: and anal sphincter pressures.

AB - PURPOSE: This study evaluates peptide tyrosine-tyrosine (PYY), intestinal transit, fecal retention time, and anal sphincter manometry in colectomized patients with ileal pouch-anal anastomosis. METHODS: Plasma and pouch PYY, mouth-to-pouch transit time, fecal retention time, and anal canal pressures were studied in 27 patients with ileoanal pouches a mean of 50 (range, 3-84) months after loop ileostomy closure. RESULTS: Basal and peak postprandial plasma PYY were significantly reduced in patients with pouches compared with controls (P <0.0001). Pouch PYY was decreased compared with control ileal PYY (P = 0.0003). No significant correlation was noted between intestinal transit and total integrated PYY response in patients with pouches (r = 0.36; P = 0.06). Fecal retention time was related to postprandial total integrated response of plasma PYY (r = 0.43; P = 0.02), mouth-to-pouch transit (r = 0.87; P <0.0001), and resting (r = 0.44; P = 0.02) and squeeze (r = 0.62; P = 0.0006) anal sphincter pressures. CONCLUSIONS: Colectomized ileoanal patients with pouches showed decreased plasma and pouch PYY compared with controls. Intestinal transit was not significantly related to PYY release. However, prolonged pouch fecal retention was associated with greater PYY release, mouth-to-pouch transit: and anal sphincter pressures.

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