Immediate and ongoing detection of prions in the blood of hamsters and deer following oral, nasal, or blood inoculations

Alan M. Elder; Davin M. Henderson; Amy V. Nalls; Edward A. Hoover; Anthony Kincaid; Jason C. Bartz; Candace K. Mathiason

doi:10.1128/JVI.00760-15

Immediate and ongoing detection of prions in the blood of hamsters and deer following oral, nasal, or blood inoculations

Alan M. Elder, Davin M. Henderson, Amy V. Nalls, Edward A. Hoover, Anthony Kincaid, Jason C. Bartz, Candace K. Mathiason

Research output: Contribution to journal › Article

20 Scopus citations

Abstract

Infectious prions traverse epithelial barriers to gain access to the circulatory system, yet the temporal parameters of transepithelial transport and persistence in the blood over time remain unknown. We used whole-blood real-time quaking-induced conversion (wbRT-QuIC) to analyze whole blood collected from transmissible spongiform encephalopathy (TSE)-inoculated deer and hamsters throughout the incubation period for the presence of common prion protein-conversion competent amyloid (PrP^C-CCA). We observed PrP^C-CCA in the blood of TSE-inoculated hosts throughout the disease course from minutes postexposure to terminal disease.

Original language	English
Pages (from-to)	7421-7424
Number of pages	4
Journal	Journal of Virology
Volume	89
Issue number	14
DOIs	https://doi.org/10.1128/JVI.00760-15
State	Published - 2015

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All Science Journal Classification (ASJC) codes

Immunology
Virology

Cite this

Elder, A. M., Henderson, D. M., Nalls, A. V., Hoover, E. A., Kincaid, A., Bartz, J. C., & Mathiason, C. K. (2015). Immediate and ongoing detection of prions in the blood of hamsters and deer following oral, nasal, or blood inoculations. Journal of Virology, 89(14), 7421-7424. https://doi.org/10.1128/JVI.00760-15

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10.1128/JVI.00760-15