Abstract
Infectious prions traverse epithelial barriers to gain access to the circulatory system, yet the temporal parameters of transepithelial transport and persistence in the blood over time remain unknown. We used whole-blood real-time quaking-induced conversion (wbRT-QuIC) to analyze whole blood collected from transmissible spongiform encephalopathy (TSE)-inoculated deer and hamsters throughout the incubation period for the presence of common prion protein-conversion competent amyloid (PrPC-CCA). We observed PrPC-CCA in the blood of TSE-inoculated hosts throughout the disease course from minutes postexposure to terminal disease.
| Original language | English |
|---|---|
| Pages (from-to) | 7421-7424 |
| Number of pages | 4 |
| Journal | Journal of Virology |
| Volume | 89 |
| Issue number | 14 |
| DOIs | |
| State | Published - 2015 |
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All Science Journal Classification (ASJC) codes
- Immunology
- Virology
Cite this
Immediate and ongoing detection of prions in the blood of hamsters and deer following oral, nasal, or blood inoculations. / Elder, Alan M.; Henderson, Davin M.; Nalls, Amy V.; Hoover, Edward A.; Kincaid, Anthony; Bartz, Jason C.; Mathiason, Candace K.
In: Journal of Virology, Vol. 89, No. 14, 2015, p. 7421-7424.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immediate and ongoing detection of prions in the blood of hamsters and deer following oral, nasal, or blood inoculations
AU - Elder, Alan M.
AU - Henderson, Davin M.
AU - Nalls, Amy V.
AU - Hoover, Edward A.
AU - Kincaid, Anthony
AU - Bartz, Jason C.
AU - Mathiason, Candace K.
PY - 2015
Y1 - 2015
N2 - Infectious prions traverse epithelial barriers to gain access to the circulatory system, yet the temporal parameters of transepithelial transport and persistence in the blood over time remain unknown. We used whole-blood real-time quaking-induced conversion (wbRT-QuIC) to analyze whole blood collected from transmissible spongiform encephalopathy (TSE)-inoculated deer and hamsters throughout the incubation period for the presence of common prion protein-conversion competent amyloid (PrPC-CCA). We observed PrPC-CCA in the blood of TSE-inoculated hosts throughout the disease course from minutes postexposure to terminal disease.
AB - Infectious prions traverse epithelial barriers to gain access to the circulatory system, yet the temporal parameters of transepithelial transport and persistence in the blood over time remain unknown. We used whole-blood real-time quaking-induced conversion (wbRT-QuIC) to analyze whole blood collected from transmissible spongiform encephalopathy (TSE)-inoculated deer and hamsters throughout the incubation period for the presence of common prion protein-conversion competent amyloid (PrPC-CCA). We observed PrPC-CCA in the blood of TSE-inoculated hosts throughout the disease course from minutes postexposure to terminal disease.
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UR - http://www.scopus.com/inward/citedby.url?scp=84931064171&partnerID=8YFLogxK
U2 - 10.1128/JVI.00760-15
DO - 10.1128/JVI.00760-15
M3 - Article
VL - 89
SP - 7421
EP - 7424
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 14
ER -