Immediate and ongoing detection of prions in the blood of hamsters and deer following oral, nasal, or blood inoculations

Alan M. Elder, Davin M. Henderson, Amy V. Nalls, Edward A. Hoover, Anthony Kincaid, Jason C. Bartz, Candace K. Mathiason

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Infectious prions traverse epithelial barriers to gain access to the circulatory system, yet the temporal parameters of transepithelial transport and persistence in the blood over time remain unknown. We used whole-blood real-time quaking-induced conversion (wbRT-QuIC) to analyze whole blood collected from transmissible spongiform encephalopathy (TSE)-inoculated deer and hamsters throughout the incubation period for the presence of common prion protein-conversion competent amyloid (PrPC-CCA). We observed PrPC-CCA in the blood of TSE-inoculated hosts throughout the disease course from minutes postexposure to terminal disease.

Original languageEnglish
Pages (from-to)7421-7424
Number of pages4
JournalJournal of Virology
Volume89
Issue number14
DOIs
StatePublished - 2015

Fingerprint

Deer
Prions
prions
Nose
hamsters
Cricetinae
deer
mouth
Prion Diseases
prion diseases
blood
amyloid
Amyloid
circulatory system
Cardiovascular System
disease course
Prion Proteins

All Science Journal Classification (ASJC) codes

  • Immunology
  • Virology

Cite this

Immediate and ongoing detection of prions in the blood of hamsters and deer following oral, nasal, or blood inoculations. / Elder, Alan M.; Henderson, Davin M.; Nalls, Amy V.; Hoover, Edward A.; Kincaid, Anthony; Bartz, Jason C.; Mathiason, Candace K.

In: Journal of Virology, Vol. 89, No. 14, 2015, p. 7421-7424.

Research output: Contribution to journalArticle

Elder, Alan M. ; Henderson, Davin M. ; Nalls, Amy V. ; Hoover, Edward A. ; Kincaid, Anthony ; Bartz, Jason C. ; Mathiason, Candace K. / Immediate and ongoing detection of prions in the blood of hamsters and deer following oral, nasal, or blood inoculations. In: Journal of Virology. 2015 ; Vol. 89, No. 14. pp. 7421-7424.
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