Immediate and ongoing detection of prions in the blood of hamsters and deer following oral, nasal, or blood inoculations

Alan M. Elder, Davin M. Henderson, Amy V. Nalls, Edward A. Hoover, Anthony Kincaid, Jason C. Bartz, Candace K. Mathiason

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Infectious prions traverse epithelial barriers to gain access to the circulatory system, yet the temporal parameters of transepithelial transport and persistence in the blood over time remain unknown. We used whole-blood real-time quaking-induced conversion (wbRT-QuIC) to analyze whole blood collected from transmissible spongiform encephalopathy (TSE)-inoculated deer and hamsters throughout the incubation period for the presence of common prion protein-conversion competent amyloid (PrPC-CCA). We observed PrPC-CCA in the blood of TSE-inoculated hosts throughout the disease course from minutes postexposure to terminal disease.

Original languageEnglish
Pages (from-to)7421-7424
Number of pages4
JournalJournal of Virology
Volume89
Issue number14
DOIs
StatePublished - 2015

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Immunology
  • Virology

Cite this