Immunobiological factors aggravating the fatty infiltration on tendons and muscles in rotator cuff lesions

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Rotator cuff lesions (RCLs) are a common cause of shoulder pain and dysfunction. The rotator cuff tendons can degenerate and/or tear from the greater tuberosity of the humerus, which is associated with several anatomical, physiological, biochemical, and molecular changes in tendon and muscle. In this article, these pathways are critically reviewed and discussed with various management strategies of RCLs. The article also highlights the immunobiological responses following the RCL and the inherent repair mechanisms elicited by the body. The greatest difficulty in treating this pathology is that the muscle can undergo irreversible fatty infiltration in the setting of chronic tears that is associated with poor surgical outcomes. The article also investigates the key molecular pathways of the muscle homeostasis (mTOR, Rho kinase, AMPK, and Ca2+) with the energy metabolism to propose a possible mechanism for fatty infiltration. Future research is warranted to target the key players of these pathways in the management of fatty infiltration and thus RCL.

Original languageEnglish
Pages (from-to)17-33
Number of pages17
JournalMolecular and Cellular Biochemistry
Volume417
Issue number1-2
DOIs
StatePublished - Jun 1 2016

Fingerprint

Rotator Cuff
Tendons
Infiltration
Muscle
Muscles
rho-Associated Kinases
AMP-Activated Protein Kinases
Tears
Pathology
Repair
Shoulder Pain
Humerus
Energy Metabolism
Homeostasis

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Immunobiological factors aggravating the fatty infiltration on tendons and muscles in rotator cuff lesions. / Thankam, Finosh G.; Dilisio, Matthew; Agrawal, Devendra K.

In: Molecular and Cellular Biochemistry, Vol. 417, No. 1-2, 01.06.2016, p. 17-33.

Research output: Contribution to journalReview article

@article{e4392f395eb64766a5c50e26de8153b3,
title = "Immunobiological factors aggravating the fatty infiltration on tendons and muscles in rotator cuff lesions",
abstract = "Rotator cuff lesions (RCLs) are a common cause of shoulder pain and dysfunction. The rotator cuff tendons can degenerate and/or tear from the greater tuberosity of the humerus, which is associated with several anatomical, physiological, biochemical, and molecular changes in tendon and muscle. In this article, these pathways are critically reviewed and discussed with various management strategies of RCLs. The article also highlights the immunobiological responses following the RCL and the inherent repair mechanisms elicited by the body. The greatest difficulty in treating this pathology is that the muscle can undergo irreversible fatty infiltration in the setting of chronic tears that is associated with poor surgical outcomes. The article also investigates the key molecular pathways of the muscle homeostasis (mTOR, Rho kinase, AMPK, and Ca2+) with the energy metabolism to propose a possible mechanism for fatty infiltration. Future research is warranted to target the key players of these pathways in the management of fatty infiltration and thus RCL.",
author = "Thankam, {Finosh G.} and Matthew Dilisio and Agrawal, {Devendra K.}",
year = "2016",
month = "6",
day = "1",
doi = "10.1007/s11010-016-2710-5",
language = "English",
volume = "417",
pages = "17--33",
journal = "Molecular and Cellular Biochemistry",
issn = "0300-8177",
publisher = "Springer Netherlands",
number = "1-2",

}

TY - JOUR

T1 - Immunobiological factors aggravating the fatty infiltration on tendons and muscles in rotator cuff lesions

AU - Thankam, Finosh G.

AU - Dilisio, Matthew

AU - Agrawal, Devendra K.

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Rotator cuff lesions (RCLs) are a common cause of shoulder pain and dysfunction. The rotator cuff tendons can degenerate and/or tear from the greater tuberosity of the humerus, which is associated with several anatomical, physiological, biochemical, and molecular changes in tendon and muscle. In this article, these pathways are critically reviewed and discussed with various management strategies of RCLs. The article also highlights the immunobiological responses following the RCL and the inherent repair mechanisms elicited by the body. The greatest difficulty in treating this pathology is that the muscle can undergo irreversible fatty infiltration in the setting of chronic tears that is associated with poor surgical outcomes. The article also investigates the key molecular pathways of the muscle homeostasis (mTOR, Rho kinase, AMPK, and Ca2+) with the energy metabolism to propose a possible mechanism for fatty infiltration. Future research is warranted to target the key players of these pathways in the management of fatty infiltration and thus RCL.

AB - Rotator cuff lesions (RCLs) are a common cause of shoulder pain and dysfunction. The rotator cuff tendons can degenerate and/or tear from the greater tuberosity of the humerus, which is associated with several anatomical, physiological, biochemical, and molecular changes in tendon and muscle. In this article, these pathways are critically reviewed and discussed with various management strategies of RCLs. The article also highlights the immunobiological responses following the RCL and the inherent repair mechanisms elicited by the body. The greatest difficulty in treating this pathology is that the muscle can undergo irreversible fatty infiltration in the setting of chronic tears that is associated with poor surgical outcomes. The article also investigates the key molecular pathways of the muscle homeostasis (mTOR, Rho kinase, AMPK, and Ca2+) with the energy metabolism to propose a possible mechanism for fatty infiltration. Future research is warranted to target the key players of these pathways in the management of fatty infiltration and thus RCL.

UR - http://www.scopus.com/inward/record.url?scp=84966552450&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84966552450&partnerID=8YFLogxK

U2 - 10.1007/s11010-016-2710-5

DO - 10.1007/s11010-016-2710-5

M3 - Review article

C2 - 27160936

AN - SCOPUS:84966552450

VL - 417

SP - 17

EP - 33

JO - Molecular and Cellular Biochemistry

JF - Molecular and Cellular Biochemistry

SN - 0300-8177

IS - 1-2

ER -