Abstract
Rotator cuff lesions (RCLs) are a common cause of shoulder pain and dysfunction. The rotator cuff tendons can degenerate and/or tear from the greater tuberosity of the humerus, which is associated with several anatomical, physiological, biochemical, and molecular changes in tendon and muscle. In this article, these pathways are critically reviewed and discussed with various management strategies of RCLs. The article also highlights the immunobiological responses following the RCL and the inherent repair mechanisms elicited by the body. The greatest difficulty in treating this pathology is that the muscle can undergo irreversible fatty infiltration in the setting of chronic tears that is associated with poor surgical outcomes. The article also investigates the key molecular pathways of the muscle homeostasis (mTOR, Rho kinase, AMPK, and Ca2+) with the energy metabolism to propose a possible mechanism for fatty infiltration. Future research is warranted to target the key players of these pathways in the management of fatty infiltration and thus RCL.
| Original language | English |
|---|---|
| Pages (from-to) | 17-33 |
| Number of pages | 17 |
| Journal | Molecular and Cellular Biochemistry |
| Volume | 417 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Jun 1 2016 |
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All Science Journal Classification (ASJC) codes
- Clinical Biochemistry
- Molecular Biology
- Cell Biology
Cite this
Immunobiological factors aggravating the fatty infiltration on tendons and muscles in rotator cuff lesions. / Thankam, Finosh G.; Dilisio, Matthew; Agrawal, Devendra K.
In: Molecular and Cellular Biochemistry, Vol. 417, No. 1-2, 01.06.2016, p. 17-33.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Immunobiological factors aggravating the fatty infiltration on tendons and muscles in rotator cuff lesions
AU - Thankam, Finosh G.
AU - Dilisio, Matthew
AU - Agrawal, Devendra K.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Rotator cuff lesions (RCLs) are a common cause of shoulder pain and dysfunction. The rotator cuff tendons can degenerate and/or tear from the greater tuberosity of the humerus, which is associated with several anatomical, physiological, biochemical, and molecular changes in tendon and muscle. In this article, these pathways are critically reviewed and discussed with various management strategies of RCLs. The article also highlights the immunobiological responses following the RCL and the inherent repair mechanisms elicited by the body. The greatest difficulty in treating this pathology is that the muscle can undergo irreversible fatty infiltration in the setting of chronic tears that is associated with poor surgical outcomes. The article also investigates the key molecular pathways of the muscle homeostasis (mTOR, Rho kinase, AMPK, and Ca2+) with the energy metabolism to propose a possible mechanism for fatty infiltration. Future research is warranted to target the key players of these pathways in the management of fatty infiltration and thus RCL.
AB - Rotator cuff lesions (RCLs) are a common cause of shoulder pain and dysfunction. The rotator cuff tendons can degenerate and/or tear from the greater tuberosity of the humerus, which is associated with several anatomical, physiological, biochemical, and molecular changes in tendon and muscle. In this article, these pathways are critically reviewed and discussed with various management strategies of RCLs. The article also highlights the immunobiological responses following the RCL and the inherent repair mechanisms elicited by the body. The greatest difficulty in treating this pathology is that the muscle can undergo irreversible fatty infiltration in the setting of chronic tears that is associated with poor surgical outcomes. The article also investigates the key molecular pathways of the muscle homeostasis (mTOR, Rho kinase, AMPK, and Ca2+) with the energy metabolism to propose a possible mechanism for fatty infiltration. Future research is warranted to target the key players of these pathways in the management of fatty infiltration and thus RCL.
UR - http://www.scopus.com/inward/record.url?scp=84966552450&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84966552450&partnerID=8YFLogxK
U2 - 10.1007/s11010-016-2710-5
DO - 10.1007/s11010-016-2710-5
M3 - Review article
C2 - 27160936
AN - SCOPUS:84966552450
VL - 417
SP - 17
EP - 33
JO - Molecular and Cellular Biochemistry
JF - Molecular and Cellular Biochemistry
SN - 0300-8177
IS - 1-2
ER -