Immunobiology of IL-37: Mechanism of action and clinical perspectives

Shannon Quirk, Devendra K. Agrawal

Research output: Contribution to journalReview articlepeer-review

48 Scopus citations


This article provides an overview of the biological function of a recently discovered cytokine, IL-37, formerly referred to as IL-1F7, and its role in chronic inflammation and autoimmune disease. Much has been discovered about IL-37 in the past decade, including its ability to down-regulate systemic and local inflammation by lowering levels of pro-inflammatory molecules. Here, we critically review the published reports. Future research is necessary to understand the receptor-dependent effects of IL-37, its intracellular and extracellular functions in both normal and diseased states and its potential role as a biomarker and pharmacological target in human disease.

Original languageEnglish
Pages (from-to)1703-1709
Number of pages7
JournalExpert Review of Clinical Immunology
Issue number12
StatePublished - Dec 1 2014

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Medicine(all)


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