Immunobiology of IL-37: Mechanism of action and clinical perspectives

Shannon Quirk, Devendra K. Agrawal

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

This article provides an overview of the biological function of a recently discovered cytokine, IL-37, formerly referred to as IL-1F7, and its role in chronic inflammation and autoimmune disease. Much has been discovered about IL-37 in the past decade, including its ability to down-regulate systemic and local inflammation by lowering levels of pro-inflammatory molecules. Here, we critically review the published reports. Future research is necessary to understand the receptor-dependent effects of IL-37, its intracellular and extracellular functions in both normal and diseased states and its potential role as a biomarker and pharmacological target in human disease.

Original languageEnglish
Pages (from-to)1703-1709
Number of pages7
JournalExpert Review of Clinical Immunology
Volume10
Issue number12
DOIs
StatePublished - Dec 1 2014

Fingerprint

Pharmacological Biomarkers
Inflammation
Autoimmune Diseases
Chronic Disease
Down-Regulation
Cytokines

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Medicine(all)

Cite this

Immunobiology of IL-37 : Mechanism of action and clinical perspectives. / Quirk, Shannon; Agrawal, Devendra K.

In: Expert Review of Clinical Immunology, Vol. 10, No. 12, 01.12.2014, p. 1703-1709.

Research output: Contribution to journalReview article

@article{e1de6c832247494fbac8b2c7b4147999,
title = "Immunobiology of IL-37: Mechanism of action and clinical perspectives",
abstract = "This article provides an overview of the biological function of a recently discovered cytokine, IL-37, formerly referred to as IL-1F7, and its role in chronic inflammation and autoimmune disease. Much has been discovered about IL-37 in the past decade, including its ability to down-regulate systemic and local inflammation by lowering levels of pro-inflammatory molecules. Here, we critically review the published reports. Future research is necessary to understand the receptor-dependent effects of IL-37, its intracellular and extracellular functions in both normal and diseased states and its potential role as a biomarker and pharmacological target in human disease.",
author = "Shannon Quirk and Agrawal, {Devendra K.}",
year = "2014",
month = "12",
day = "1",
doi = "10.1586/1744666X.2014.971014",
language = "English",
volume = "10",
pages = "1703--1709",
journal = "Expert Review of Clinical Immunology",
issn = "1744-666X",
publisher = "Expert Reviews Ltd.",
number = "12",

}

TY - JOUR

T1 - Immunobiology of IL-37

T2 - Mechanism of action and clinical perspectives

AU - Quirk, Shannon

AU - Agrawal, Devendra K.

PY - 2014/12/1

Y1 - 2014/12/1

N2 - This article provides an overview of the biological function of a recently discovered cytokine, IL-37, formerly referred to as IL-1F7, and its role in chronic inflammation and autoimmune disease. Much has been discovered about IL-37 in the past decade, including its ability to down-regulate systemic and local inflammation by lowering levels of pro-inflammatory molecules. Here, we critically review the published reports. Future research is necessary to understand the receptor-dependent effects of IL-37, its intracellular and extracellular functions in both normal and diseased states and its potential role as a biomarker and pharmacological target in human disease.

AB - This article provides an overview of the biological function of a recently discovered cytokine, IL-37, formerly referred to as IL-1F7, and its role in chronic inflammation and autoimmune disease. Much has been discovered about IL-37 in the past decade, including its ability to down-regulate systemic and local inflammation by lowering levels of pro-inflammatory molecules. Here, we critically review the published reports. Future research is necessary to understand the receptor-dependent effects of IL-37, its intracellular and extracellular functions in both normal and diseased states and its potential role as a biomarker and pharmacological target in human disease.

UR - http://www.scopus.com/inward/record.url?scp=84911092624&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84911092624&partnerID=8YFLogxK

U2 - 10.1586/1744666X.2014.971014

DO - 10.1586/1744666X.2014.971014

M3 - Review article

C2 - 25327443

AN - SCOPUS:84911092624

VL - 10

SP - 1703

EP - 1709

JO - Expert Review of Clinical Immunology

JF - Expert Review of Clinical Immunology

SN - 1744-666X

IS - 12

ER -