Abstract
This article provides an overview of the biological function of a recently discovered cytokine, IL-37, formerly referred to as IL-1F7, and its role in chronic inflammation and autoimmune disease. Much has been discovered about IL-37 in the past decade, including its ability to down-regulate systemic and local inflammation by lowering levels of pro-inflammatory molecules. Here, we critically review the published reports. Future research is necessary to understand the receptor-dependent effects of IL-37, its intracellular and extracellular functions in both normal and diseased states and its potential role as a biomarker and pharmacological target in human disease.
| Original language | English |
|---|---|
| Pages (from-to) | 1703-1709 |
| Number of pages | 7 |
| Journal | Expert Review of Clinical Immunology |
| Volume | 10 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1 2014 |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
- Medicine(all)
Cite this
Immunobiology of IL-37 : Mechanism of action and clinical perspectives. / Quirk, Shannon; Agrawal, Devendra K.
In: Expert Review of Clinical Immunology, Vol. 10, No. 12, 01.12.2014, p. 1703-1709.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Immunobiology of IL-37
T2 - Mechanism of action and clinical perspectives
AU - Quirk, Shannon
AU - Agrawal, Devendra K.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - This article provides an overview of the biological function of a recently discovered cytokine, IL-37, formerly referred to as IL-1F7, and its role in chronic inflammation and autoimmune disease. Much has been discovered about IL-37 in the past decade, including its ability to down-regulate systemic and local inflammation by lowering levels of pro-inflammatory molecules. Here, we critically review the published reports. Future research is necessary to understand the receptor-dependent effects of IL-37, its intracellular and extracellular functions in both normal and diseased states and its potential role as a biomarker and pharmacological target in human disease.
AB - This article provides an overview of the biological function of a recently discovered cytokine, IL-37, formerly referred to as IL-1F7, and its role in chronic inflammation and autoimmune disease. Much has been discovered about IL-37 in the past decade, including its ability to down-regulate systemic and local inflammation by lowering levels of pro-inflammatory molecules. Here, we critically review the published reports. Future research is necessary to understand the receptor-dependent effects of IL-37, its intracellular and extracellular functions in both normal and diseased states and its potential role as a biomarker and pharmacological target in human disease.
UR - http://www.scopus.com/inward/record.url?scp=84911092624&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84911092624&partnerID=8YFLogxK
U2 - 10.1586/1744666X.2014.971014
DO - 10.1586/1744666X.2014.971014
M3 - Review article
VL - 10
SP - 1703
EP - 1709
JO - Expert Review of Clinical Immunology
JF - Expert Review of Clinical Immunology
SN - 1744-666X
IS - 12
ER -