Abstract
Introduction: Wear debris-induced osteolysis is a common cause of arthroplasty failure in several joints including the knee, hip and intervertebral disc. Debris from the prosthesis can trigger an inflammatory response that leads to aseptic loosening and prosthesis failure. In the spine, periprosthetic pain also occurs following accumulation of wear debris through neovascularization of the disc. The role of the immune system in the pathobiology of periprosthetic osteolysis of joint replacements is debatable. Areas covered: We discussed the stimulation of pro-inflammatory and pro-protective and pro-regenerative pathways due to debris from the prosthetics. The balance between the two pathways may determine the outcome results. Also, the role of cytokines and immune cells in periprosthetic inflammation in the etiology of osteolysis is critically reviewed. Expert commentary: Therapies targeting the inflammatory process associated with ultra-high-molecular-weight polyethylene wear debris could reduce implant failure. Additionally, therapies targeting neovascularization of discs following arthroplasty could mitigate periprosthetic pain.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 695-706 |
| Number of pages | 12 |
| Journal | Expert Review of Clinical Immunology |
| Volume | 14 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 3 2018 |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
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Immunobiology of periprosthetic inflammation and pain following ultra-high-molecular-weight-polyethylene wear debris in the lumbar spine. / Werner, John H.; Rosenberg, John H.; Keeley, Kristen L.; Agrawal, Devendra K.
In: Expert Review of Clinical Immunology, Vol. 14, No. 8, 03.08.2018, p. 695-706.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Immunobiology of periprosthetic inflammation and pain following ultra-high-molecular-weight-polyethylene wear debris in the lumbar spine
AU - Werner, John H.
AU - Rosenberg, John H.
AU - Keeley, Kristen L.
AU - Agrawal, Devendra K.
PY - 2018/8/3
Y1 - 2018/8/3
N2 - Introduction: Wear debris-induced osteolysis is a common cause of arthroplasty failure in several joints including the knee, hip and intervertebral disc. Debris from the prosthesis can trigger an inflammatory response that leads to aseptic loosening and prosthesis failure. In the spine, periprosthetic pain also occurs following accumulation of wear debris through neovascularization of the disc. The role of the immune system in the pathobiology of periprosthetic osteolysis of joint replacements is debatable. Areas covered: We discussed the stimulation of pro-inflammatory and pro-protective and pro-regenerative pathways due to debris from the prosthetics. The balance between the two pathways may determine the outcome results. Also, the role of cytokines and immune cells in periprosthetic inflammation in the etiology of osteolysis is critically reviewed. Expert commentary: Therapies targeting the inflammatory process associated with ultra-high-molecular-weight polyethylene wear debris could reduce implant failure. Additionally, therapies targeting neovascularization of discs following arthroplasty could mitigate periprosthetic pain.
AB - Introduction: Wear debris-induced osteolysis is a common cause of arthroplasty failure in several joints including the knee, hip and intervertebral disc. Debris from the prosthesis can trigger an inflammatory response that leads to aseptic loosening and prosthesis failure. In the spine, periprosthetic pain also occurs following accumulation of wear debris through neovascularization of the disc. The role of the immune system in the pathobiology of periprosthetic osteolysis of joint replacements is debatable. Areas covered: We discussed the stimulation of pro-inflammatory and pro-protective and pro-regenerative pathways due to debris from the prosthetics. The balance between the two pathways may determine the outcome results. Also, the role of cytokines and immune cells in periprosthetic inflammation in the etiology of osteolysis is critically reviewed. Expert commentary: Therapies targeting the inflammatory process associated with ultra-high-molecular-weight polyethylene wear debris could reduce implant failure. Additionally, therapies targeting neovascularization of discs following arthroplasty could mitigate periprosthetic pain.
UR - http://www.scopus.com/inward/record.url?scp=85052912897&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85052912897&partnerID=8YFLogxK
U2 - 10.1080/1744666X.2018.1511428
DO - 10.1080/1744666X.2018.1511428
M3 - Review article
C2 - 30099915
AN - SCOPUS:85052912897
VL - 14
SP - 695
EP - 706
JO - Expert Review of Clinical Immunology
JF - Expert Review of Clinical Immunology
SN - 1744-666X
IS - 8
ER -