Immunological and molecular basis of nonalcoholic steatohepatitis and nonalcoholic fatty liver disease

Mohamed M. Radwan, Basil M. Radwan, Kalyana C. Nandipati, William J. Hunter, Devendra K. Agrawal

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

The prevalence of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) is rising worldwide with the increasing incidence of obesity, Type 2 diabetes mellitus and metabolic syndrome. NASH is currently one of the most common indications of liver transplantation in the United States. The immune system plays a major role in the pathogenesis of NAFLD/NASH. The metabolic changes, associated with obesity and metabolic syndrome, induce immunological responses resulting in NAFLD and further aggravation of the metabolic derangement in a feed-forward loop. Genetic and endocrine factors modulate the immunological and metabolic responses and determine the pathophysiological features of NAFLD. Histologically, NAFLD is a spectrum that ranges from simple hepatic steatosis to severe steatohepatitis, liver cirrhosis and/or hepatocellular carcinoma. Liver cirrhosis and hepatocellular carcinoma are responsible for the morbidity and mortality of the disease. This article is a critical evaluation of our current knowledge of the immunological and molecular basis of the disease.

Original languageEnglish
Pages (from-to)727-738
Number of pages12
JournalExpert Review of Clinical Immunology
Volume9
Issue number8
DOIs
StatePublished - Aug 2013

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Liver Cirrhosis
Hepatocellular Carcinoma
Obesity
Non-alcoholic Fatty Liver Disease
Immunologic Factors
Fatty Liver
Liver Transplantation
Type 2 Diabetes Mellitus
Immune System
Morbidity
Mortality
Liver
Incidence

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Immunological and molecular basis of nonalcoholic steatohepatitis and nonalcoholic fatty liver disease. / Radwan, Mohamed M.; Radwan, Basil M.; Nandipati, Kalyana C.; Hunter, William J.; Agrawal, Devendra K.

In: Expert Review of Clinical Immunology, Vol. 9, No. 8, 08.2013, p. 727-738.

Research output: Contribution to journalReview article

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