Immunological basis for treatment of graft versus host disease after liver transplant

Vikrant Rai, Nicholas Edward Dietz, Devendra K. Agrawal

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Graft versus host disease (GVHD) after liver transplant, although a rare disease, has a very high mortality rate. GVHD occurs due to immunoreactions caused by donor T lymphocytes and host cell surface antigens resulting in proliferation and clonal expansion of T lymphocyte. Migration of effector cells, including macrophages, NK cells and cytotoxic T lymphocyte, to the target organs such as skin, intestine and bone marrow results in skin rashes, diarrhea and bone marrow depression. GVHD is diagnosed by clinical symptoms, histopathological findings and by the presence of chimerism. The delayed diagnosis, opportunistic infections and lack of definitive treatment of post orthotopic liver transplant (OLT)-GVHD results in sepsis and multi-organ failure leading to very low survival rates. In this review, we have focused on early diagnosis and critically discuss novel treatment modalities to decrease the incidence of GVHD.

Original languageEnglish
Pages (from-to)583-593
Number of pages11
JournalExpert Review of Clinical Immunology
Volume12
Issue number5
DOIs
StatePublished - May 3 2016

Fingerprint

Graft vs Host Disease
Transplants
Liver
Bone Marrow
T-Lymphocytes
Therapeutics
Chimerism
Delayed Diagnosis
Opportunistic Infections
Cytotoxic T-Lymphocytes
Surface Antigens
Rare Diseases
Exanthema
Natural Killer Cells
Intestines
Cell Movement
Early Diagnosis
Diarrhea
Sepsis
Survival Rate

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Immunological basis for treatment of graft versus host disease after liver transplant. / Rai, Vikrant; Dietz, Nicholas Edward; Agrawal, Devendra K.

In: Expert Review of Clinical Immunology, Vol. 12, No. 5, 03.05.2016, p. 583-593.

Research output: Contribution to journalReview article

@article{21c9f4b650f54317b2d0c792d80f4580,
title = "Immunological basis for treatment of graft versus host disease after liver transplant",
abstract = "Graft versus host disease (GVHD) after liver transplant, although a rare disease, has a very high mortality rate. GVHD occurs due to immunoreactions caused by donor T lymphocytes and host cell surface antigens resulting in proliferation and clonal expansion of T lymphocyte. Migration of effector cells, including macrophages, NK cells and cytotoxic T lymphocyte, to the target organs such as skin, intestine and bone marrow results in skin rashes, diarrhea and bone marrow depression. GVHD is diagnosed by clinical symptoms, histopathological findings and by the presence of chimerism. The delayed diagnosis, opportunistic infections and lack of definitive treatment of post orthotopic liver transplant (OLT)-GVHD results in sepsis and multi-organ failure leading to very low survival rates. In this review, we have focused on early diagnosis and critically discuss novel treatment modalities to decrease the incidence of GVHD.",
author = "Vikrant Rai and Dietz, {Nicholas Edward} and Agrawal, {Devendra K.}",
year = "2016",
month = "5",
day = "3",
doi = "10.1586/1744666X.2016.1145056",
language = "English",
volume = "12",
pages = "583--593",
journal = "Expert Review of Clinical Immunology",
issn = "1744-666X",
publisher = "Expert Reviews Ltd.",
number = "5",

}

TY - JOUR

T1 - Immunological basis for treatment of graft versus host disease after liver transplant

AU - Rai, Vikrant

AU - Dietz, Nicholas Edward

AU - Agrawal, Devendra K.

PY - 2016/5/3

Y1 - 2016/5/3

N2 - Graft versus host disease (GVHD) after liver transplant, although a rare disease, has a very high mortality rate. GVHD occurs due to immunoreactions caused by donor T lymphocytes and host cell surface antigens resulting in proliferation and clonal expansion of T lymphocyte. Migration of effector cells, including macrophages, NK cells and cytotoxic T lymphocyte, to the target organs such as skin, intestine and bone marrow results in skin rashes, diarrhea and bone marrow depression. GVHD is diagnosed by clinical symptoms, histopathological findings and by the presence of chimerism. The delayed diagnosis, opportunistic infections and lack of definitive treatment of post orthotopic liver transplant (OLT)-GVHD results in sepsis and multi-organ failure leading to very low survival rates. In this review, we have focused on early diagnosis and critically discuss novel treatment modalities to decrease the incidence of GVHD.

AB - Graft versus host disease (GVHD) after liver transplant, although a rare disease, has a very high mortality rate. GVHD occurs due to immunoreactions caused by donor T lymphocytes and host cell surface antigens resulting in proliferation and clonal expansion of T lymphocyte. Migration of effector cells, including macrophages, NK cells and cytotoxic T lymphocyte, to the target organs such as skin, intestine and bone marrow results in skin rashes, diarrhea and bone marrow depression. GVHD is diagnosed by clinical symptoms, histopathological findings and by the presence of chimerism. The delayed diagnosis, opportunistic infections and lack of definitive treatment of post orthotopic liver transplant (OLT)-GVHD results in sepsis and multi-organ failure leading to very low survival rates. In this review, we have focused on early diagnosis and critically discuss novel treatment modalities to decrease the incidence of GVHD.

UR - http://www.scopus.com/inward/record.url?scp=84959055395&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84959055395&partnerID=8YFLogxK

U2 - 10.1586/1744666X.2016.1145056

DO - 10.1586/1744666X.2016.1145056

M3 - Review article

C2 - 26795873

AN - SCOPUS:84959055395

VL - 12

SP - 583

EP - 593

JO - Expert Review of Clinical Immunology

JF - Expert Review of Clinical Immunology

SN - 1744-666X

IS - 5

ER -