Immunological basis in the pathogenesis and treatment of bladder cancer

David B. Thompson, Larry Siref, Michael Feloney, Ralph J. Hauke, Devendra K. Agrawal

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

The pathogenesis and transition of normal urothelium into bladder carcinoma are multifactorial processes. Chronic inflammation causes initiation and progression of the underlying pathophysiology of invasive and metastatic cancer. A dichotomy is observed in the role of immune cells in bladder cancer. While the immune response defends the host by suppressing neoplastic growth, several immune cells, including neutrophils, macrophages and T-lymphocytes, promote tumor development and progression. The levels of human neutrophil peptide-1, -2 and -3, produced by neutrophils, increase in bladder cancer and might promote tumor angiogenesis and growth. The effect of macrophages is primarily mediated by pro-inflammatory cytokines, IL-6 and TNF-α. In addition, the underlying immunological mechanisms of two treatments, BCG and cytokine gene-modified tumor vaccines, and future directions are critically discussed.

Original languageEnglish
Pages (from-to)265-279
Number of pages15
JournalExpert Review of Clinical Immunology
Volume11
Issue number2
DOIs
StatePublished - Feb 1 2015

Fingerprint

Urinary Bladder Neoplasms
Neutrophils
Macrophages
Cytokines
Urothelium
Neoplasms
Cancer Vaccines
Mycobacterium bovis
Growth
Interleukin-6
Urinary Bladder
Inflammation
Carcinoma
T-Lymphocytes
Genes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Medicine(all)

Cite this

Immunological basis in the pathogenesis and treatment of bladder cancer. / Thompson, David B.; Siref, Larry; Feloney, Michael; Hauke, Ralph J.; Agrawal, Devendra K.

In: Expert Review of Clinical Immunology, Vol. 11, No. 2, 01.02.2015, p. 265-279.

Research output: Contribution to journalReview article

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