Abstract
The pathogenesis and transition of normal urothelium into bladder carcinoma are multifactorial processes. Chronic inflammation causes initiation and progression of the underlying pathophysiology of invasive and metastatic cancer. A dichotomy is observed in the role of immune cells in bladder cancer. While the immune response defends the host by suppressing neoplastic growth, several immune cells, including neutrophils, macrophages and T-lymphocytes, promote tumor development and progression. The levels of human neutrophil peptide-1, -2 and -3, produced by neutrophils, increase in bladder cancer and might promote tumor angiogenesis and growth. The effect of macrophages is primarily mediated by pro-inflammatory cytokines, IL-6 and TNF-α. In addition, the underlying immunological mechanisms of two treatments, BCG and cytokine gene-modified tumor vaccines, and future directions are critically discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 265-279 |
| Number of pages | 15 |
| Journal | Expert Review of Clinical Immunology |
| Volume | 11 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2015 |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
- Medicine(all)
Cite this
Immunological basis in the pathogenesis and treatment of bladder cancer. / Thompson, David B.; Siref, Larry; Feloney, Michael; Hauke, Ralph J.; Agrawal, Devendra K.
In: Expert Review of Clinical Immunology, Vol. 11, No. 2, 01.02.2015, p. 265-279.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Immunological basis in the pathogenesis and treatment of bladder cancer
AU - Thompson, David B.
AU - Siref, Larry
AU - Feloney, Michael
AU - Hauke, Ralph J.
AU - Agrawal, Devendra K.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - The pathogenesis and transition of normal urothelium into bladder carcinoma are multifactorial processes. Chronic inflammation causes initiation and progression of the underlying pathophysiology of invasive and metastatic cancer. A dichotomy is observed in the role of immune cells in bladder cancer. While the immune response defends the host by suppressing neoplastic growth, several immune cells, including neutrophils, macrophages and T-lymphocytes, promote tumor development and progression. The levels of human neutrophil peptide-1, -2 and -3, produced by neutrophils, increase in bladder cancer and might promote tumor angiogenesis and growth. The effect of macrophages is primarily mediated by pro-inflammatory cytokines, IL-6 and TNF-α. In addition, the underlying immunological mechanisms of two treatments, BCG and cytokine gene-modified tumor vaccines, and future directions are critically discussed.
AB - The pathogenesis and transition of normal urothelium into bladder carcinoma are multifactorial processes. Chronic inflammation causes initiation and progression of the underlying pathophysiology of invasive and metastatic cancer. A dichotomy is observed in the role of immune cells in bladder cancer. While the immune response defends the host by suppressing neoplastic growth, several immune cells, including neutrophils, macrophages and T-lymphocytes, promote tumor development and progression. The levels of human neutrophil peptide-1, -2 and -3, produced by neutrophils, increase in bladder cancer and might promote tumor angiogenesis and growth. The effect of macrophages is primarily mediated by pro-inflammatory cytokines, IL-6 and TNF-α. In addition, the underlying immunological mechanisms of two treatments, BCG and cytokine gene-modified tumor vaccines, and future directions are critically discussed.
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UR - http://www.scopus.com/inward/citedby.url?scp=84921340375&partnerID=8YFLogxK
U2 - 10.1586/1744666X.2015.983082
DO - 10.1586/1744666X.2015.983082
M3 - Review article
C2 - 25391391
AN - SCOPUS:84921340375
VL - 11
SP - 265
EP - 279
JO - Expert Review of Clinical Immunology
JF - Expert Review of Clinical Immunology
SN - 1744-666X
IS - 2
ER -