Immunological basis in the pathogenesis of intrahepatic cholestasis of pregnancy

Spencer P. Larson, Oormila Kovilam, Devendra K. Agrawal

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Intrahepatic cholestasis of pregnancy poses a great risk to both maternal and fetal health. Despite extensive research, much of the pathogenesis of this disorder is unknown. The increase in bile acids observed in patients with intrahepatic cholestasis of pregnancy has been noted to cause a change in the immune system from the normally mediated TH2 response to one that is more oriented towards TH1. In this literature review, we have critically reviewed the current literature regarding the changes in the immune system and the potential effects of immunological changes in the management of the patient. The current treatment, ursodeoxycholic acid, is also discussed along with potential combination therapies and future directions for research.

Original languageEnglish
Pages (from-to)39-48
Number of pages10
JournalExpert Review of Clinical Immunology
Volume12
Issue number1
DOIs
StatePublished - Jan 2 2016

Fingerprint

Immune System
Ursodeoxycholic Acid
Bile Acids and Salts
Research
Therapeutics
Intrahepatic Cholestasis of Pregnancy
Maternal Health
Direction compound

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Immunological basis in the pathogenesis of intrahepatic cholestasis of pregnancy. / Larson, Spencer P.; Kovilam, Oormila; Agrawal, Devendra K.

In: Expert Review of Clinical Immunology, Vol. 12, No. 1, 02.01.2016, p. 39-48.

Research output: Contribution to journalReview article

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