Immunomodulatory role of vascular endothelial growth factor and angiopoietin-1 in airway remodeling

Toluwalope Makinde, Richard F. Murphy, Devendra K. Agrawal

Research output: Contribution to journalReview article

36 Citations (Scopus)

Abstract

The blood vessels formed in asthmatic airways are involved in inflammatory and airway remodeling processes in chronic asthma. Vascular endothelial cell growth factor (VEGF) and angiopoietin-1 (Ang-1) are primary angiogenic growth factors, involved in the formation of such blood vessels. VEGF has been reported to contribute to non-specific airway hyper-responsiveness, have chemotactic effects on eosinophils, and enhance airway smooth muscle cell proliferation. Furthermore, Th2 cells have receptors for VEGF, and Th2-associated cytokines increase VEGF production. There are reports that elevated levels of VEGF correlates with the severity of asthma. Ang-1 has been shown to induce pro-inflammatory effects such as eosinophil chemotaxis via tie-2 receptors. Reports indicate ang-1 contribution to increased secretion of matrix metalloproteinase-2 (MMP-2) and decreased secretion of tissue inhibitors of metalloproteinase-2 (TIMP-2). However, Ang-1 has also been shown to exhibit several anti-inflammatory properties such as suppressing expression of adhesion molecules, blocking vascular permeability and eosinophil chemotaxis induced by VEGF. These findings support the notion that apart from their roles in blood vessels formation, these angiogenic growth factors are directly involved in the pathogenesis of chronic asthma. This paper reviews individual and combined roles of VEGF and Ang-1. The potential therapeutic applications involving these factors are also discussed.

Original languageEnglish
Pages (from-to)831-841
Number of pages11
JournalCurrent Molecular Medicine
Volume6
Issue number8
DOIs
StatePublished - Dec 2006

Fingerprint

Angiopoietin-1
Airway Remodeling
Vascular Endothelial Growth Factor A
Intercellular Signaling Peptides and Proteins
Endothelial cells
Cell growth
Eosinophils
Blood Vessels
Blood vessels
Asthma
Angiogenesis Inducing Agents
Chemotaxis
Respiratory Hypersensitivity
Tissue Inhibitor of Metalloproteinase-2
Th2 Cells
Vascular Endothelial Growth Factor Receptor
Matrix Metalloproteinase 2
Capillary Permeability
Smooth Muscle Myocytes
Cell proliferation

All Science Journal Classification (ASJC) codes

  • Biochemistry

Cite this

Immunomodulatory role of vascular endothelial growth factor and angiopoietin-1 in airway remodeling. / Makinde, Toluwalope; Murphy, Richard F.; Agrawal, Devendra K.

In: Current Molecular Medicine, Vol. 6, No. 8, 12.2006, p. 831-841.

Research output: Contribution to journalReview article

@article{acc74b74cd0047aeaa9846b3d7673880,
title = "Immunomodulatory role of vascular endothelial growth factor and angiopoietin-1 in airway remodeling",
abstract = "The blood vessels formed in asthmatic airways are involved in inflammatory and airway remodeling processes in chronic asthma. Vascular endothelial cell growth factor (VEGF) and angiopoietin-1 (Ang-1) are primary angiogenic growth factors, involved in the formation of such blood vessels. VEGF has been reported to contribute to non-specific airway hyper-responsiveness, have chemotactic effects on eosinophils, and enhance airway smooth muscle cell proliferation. Furthermore, Th2 cells have receptors for VEGF, and Th2-associated cytokines increase VEGF production. There are reports that elevated levels of VEGF correlates with the severity of asthma. Ang-1 has been shown to induce pro-inflammatory effects such as eosinophil chemotaxis via tie-2 receptors. Reports indicate ang-1 contribution to increased secretion of matrix metalloproteinase-2 (MMP-2) and decreased secretion of tissue inhibitors of metalloproteinase-2 (TIMP-2). However, Ang-1 has also been shown to exhibit several anti-inflammatory properties such as suppressing expression of adhesion molecules, blocking vascular permeability and eosinophil chemotaxis induced by VEGF. These findings support the notion that apart from their roles in blood vessels formation, these angiogenic growth factors are directly involved in the pathogenesis of chronic asthma. This paper reviews individual and combined roles of VEGF and Ang-1. The potential therapeutic applications involving these factors are also discussed.",
author = "Toluwalope Makinde and Murphy, {Richard F.} and Agrawal, {Devendra K.}",
year = "2006",
month = "12",
doi = "10.2174/156652406779010795",
language = "English",
volume = "6",
pages = "831--841",
journal = "Current Molecular Medicine",
issn = "1566-5240",
publisher = "Bentham Science Publishers B.V.",
number = "8",

}

TY - JOUR

T1 - Immunomodulatory role of vascular endothelial growth factor and angiopoietin-1 in airway remodeling

AU - Makinde, Toluwalope

AU - Murphy, Richard F.

AU - Agrawal, Devendra K.

PY - 2006/12

Y1 - 2006/12

N2 - The blood vessels formed in asthmatic airways are involved in inflammatory and airway remodeling processes in chronic asthma. Vascular endothelial cell growth factor (VEGF) and angiopoietin-1 (Ang-1) are primary angiogenic growth factors, involved in the formation of such blood vessels. VEGF has been reported to contribute to non-specific airway hyper-responsiveness, have chemotactic effects on eosinophils, and enhance airway smooth muscle cell proliferation. Furthermore, Th2 cells have receptors for VEGF, and Th2-associated cytokines increase VEGF production. There are reports that elevated levels of VEGF correlates with the severity of asthma. Ang-1 has been shown to induce pro-inflammatory effects such as eosinophil chemotaxis via tie-2 receptors. Reports indicate ang-1 contribution to increased secretion of matrix metalloproteinase-2 (MMP-2) and decreased secretion of tissue inhibitors of metalloproteinase-2 (TIMP-2). However, Ang-1 has also been shown to exhibit several anti-inflammatory properties such as suppressing expression of adhesion molecules, blocking vascular permeability and eosinophil chemotaxis induced by VEGF. These findings support the notion that apart from their roles in blood vessels formation, these angiogenic growth factors are directly involved in the pathogenesis of chronic asthma. This paper reviews individual and combined roles of VEGF and Ang-1. The potential therapeutic applications involving these factors are also discussed.

AB - The blood vessels formed in asthmatic airways are involved in inflammatory and airway remodeling processes in chronic asthma. Vascular endothelial cell growth factor (VEGF) and angiopoietin-1 (Ang-1) are primary angiogenic growth factors, involved in the formation of such blood vessels. VEGF has been reported to contribute to non-specific airway hyper-responsiveness, have chemotactic effects on eosinophils, and enhance airway smooth muscle cell proliferation. Furthermore, Th2 cells have receptors for VEGF, and Th2-associated cytokines increase VEGF production. There are reports that elevated levels of VEGF correlates with the severity of asthma. Ang-1 has been shown to induce pro-inflammatory effects such as eosinophil chemotaxis via tie-2 receptors. Reports indicate ang-1 contribution to increased secretion of matrix metalloproteinase-2 (MMP-2) and decreased secretion of tissue inhibitors of metalloproteinase-2 (TIMP-2). However, Ang-1 has also been shown to exhibit several anti-inflammatory properties such as suppressing expression of adhesion molecules, blocking vascular permeability and eosinophil chemotaxis induced by VEGF. These findings support the notion that apart from their roles in blood vessels formation, these angiogenic growth factors are directly involved in the pathogenesis of chronic asthma. This paper reviews individual and combined roles of VEGF and Ang-1. The potential therapeutic applications involving these factors are also discussed.

UR - http://www.scopus.com/inward/record.url?scp=33845350849&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845350849&partnerID=8YFLogxK

U2 - 10.2174/156652406779010795

DO - 10.2174/156652406779010795

M3 - Review article

VL - 6

SP - 831

EP - 841

JO - Current Molecular Medicine

JF - Current Molecular Medicine

SN - 1566-5240

IS - 8

ER -