Abstract
Worldwide, preeclampsia is a significant health risk to both pregnant women and their unborn children. Despite scientific advances, the exact pathogenesis of preeclampsia is not yet fully understood. Meanwhile, the incidence of preeclampsia is expected to increase. A series of potential etiologies for preeclampsia has been identified, including endothelial dysfunction, immunological dysregulation and trophoblastic invasion. In this literature review, we have critically reviewed existing literature regarding the research findings that link the role of vitamin D to the pathogenesis and immunoregulation of preeclampsia. The relationship of vitamin D with the suspected etiologies of preeclampsia underscores its clinical potential in the diagnosis and treatment of preeclampsia.
| Original language | English |
|---|---|
| Pages (from-to) | 1055-1063 |
| Number of pages | 9 |
| Journal | Expert Review of Clinical Immunology |
| Volume | 11 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2 2015 |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
Cite this
Immunomodulatory role of Vitamin D in the pathogenesis of preeclampsia. / Smith, Tyler A.; Kirkpatrick, Daniel R.; Kovilam, Oormila; Agrawal, Devendra K.
In: Expert Review of Clinical Immunology, Vol. 11, No. 9, 02.09.2015, p. 1055-1063.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Immunomodulatory role of Vitamin D in the pathogenesis of preeclampsia
AU - Smith, Tyler A.
AU - Kirkpatrick, Daniel R.
AU - Kovilam, Oormila
AU - Agrawal, Devendra K.
PY - 2015/9/2
Y1 - 2015/9/2
N2 - Worldwide, preeclampsia is a significant health risk to both pregnant women and their unborn children. Despite scientific advances, the exact pathogenesis of preeclampsia is not yet fully understood. Meanwhile, the incidence of preeclampsia is expected to increase. A series of potential etiologies for preeclampsia has been identified, including endothelial dysfunction, immunological dysregulation and trophoblastic invasion. In this literature review, we have critically reviewed existing literature regarding the research findings that link the role of vitamin D to the pathogenesis and immunoregulation of preeclampsia. The relationship of vitamin D with the suspected etiologies of preeclampsia underscores its clinical potential in the diagnosis and treatment of preeclampsia.
AB - Worldwide, preeclampsia is a significant health risk to both pregnant women and their unborn children. Despite scientific advances, the exact pathogenesis of preeclampsia is not yet fully understood. Meanwhile, the incidence of preeclampsia is expected to increase. A series of potential etiologies for preeclampsia has been identified, including endothelial dysfunction, immunological dysregulation and trophoblastic invasion. In this literature review, we have critically reviewed existing literature regarding the research findings that link the role of vitamin D to the pathogenesis and immunoregulation of preeclampsia. The relationship of vitamin D with the suspected etiologies of preeclampsia underscores its clinical potential in the diagnosis and treatment of preeclampsia.
UR - http://www.scopus.com/inward/record.url?scp=84939625872&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84939625872&partnerID=8YFLogxK
U2 - 10.1586/1744666X.2015.1056780
DO - 10.1586/1744666X.2015.1056780
M3 - Review article
VL - 11
SP - 1055
EP - 1063
JO - Expert Review of Clinical Immunology
JF - Expert Review of Clinical Immunology
SN - 1744-666X
IS - 9
ER -