Immunomodulatory role of Vitamin D in the pathogenesis of preeclampsia

Tyler A. Smith, Daniel R. Kirkpatrick, Oormila Kovilam, Devendra K. Agrawal

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


Worldwide, preeclampsia is a significant health risk to both pregnant women and their unborn children. Despite scientific advances, the exact pathogenesis of preeclampsia is not yet fully understood. Meanwhile, the incidence of preeclampsia is expected to increase. A series of potential etiologies for preeclampsia has been identified, including endothelial dysfunction, immunological dysregulation and trophoblastic invasion. In this literature review, we have critically reviewed existing literature regarding the research findings that link the role of vitamin D to the pathogenesis and immunoregulation of preeclampsia. The relationship of vitamin D with the suspected etiologies of preeclampsia underscores its clinical potential in the diagnosis and treatment of preeclampsia.

Original languageEnglish
Pages (from-to)1055-1063
Number of pages9
JournalExpert Review of Clinical Immunology
Issue number9
StatePublished - Sep 2 2015

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology


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