Immunomodulatory role of Vitamin D in the pathogenesis of preeclampsia

Tyler A. Smith, Daniel R. Kirkpatrick, Oormila Kovilam, Devendra K. Agrawal

    Research output: Contribution to journalReview articlepeer-review

    16 Scopus citations


    Worldwide, preeclampsia is a significant health risk to both pregnant women and their unborn children. Despite scientific advances, the exact pathogenesis of preeclampsia is not yet fully understood. Meanwhile, the incidence of preeclampsia is expected to increase. A series of potential etiologies for preeclampsia has been identified, including endothelial dysfunction, immunological dysregulation and trophoblastic invasion. In this literature review, we have critically reviewed existing literature regarding the research findings that link the role of vitamin D to the pathogenesis and immunoregulation of preeclampsia. The relationship of vitamin D with the suspected etiologies of preeclampsia underscores its clinical potential in the diagnosis and treatment of preeclampsia.

    Original languageEnglish
    Pages (from-to)1055-1063
    Number of pages9
    JournalExpert Review of Clinical Immunology
    Issue number9
    StatePublished - Sep 2 2015

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology


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