Immunopathogenesis and biomarkers of recurrent atrial fibrillation following ablation therapy in patients with preexisting atrial fibrillation

John H. Rosenberg, John H. Werner, Gilman D. Plitt, Victoria V. Noble, Jordan T. Spring, Brooke A. Stephens, Aleem Siddique, Helenmari L. Merritt-Genore, Michael J. Moulton, Devendra K. Agrawal

Research output: Contribution to journalReview article

Abstract

Introduction: Recurrent atrial fibrillation (RAF) following ablation therapy occurs in about 50% of patients. The pathogenesis of RAF is unknown, but is believed to be driven by atrial remodeling in the setting of background inflammation. Structural, electrophysiological and mechanical remodeling has been associated with atrial fibrillation (AF). Inflammation and fibrotic remodeling are the major factors perpetuating AF, as mediators released from the atrial tissues and cardiomyocytes due to mechanical and surgical injury could initiate the inflammatory process. In this article, we have critically reviewed the key mediators that may serve as potential biomarkers to predict RAF. Areas covered: Damage associated molecular patterns, heat shock proteins, inflammatory cytokines, non-inflammatory markers, markers of inflammatory cell activity, and markers of collagen deposition and metabolism are evaluated as potential biomarkers with molecular treatment options in RAF. Expert commentary: Establishing biomarkers to predict RAF could be useful in reducing morbidity and mortality. Investigations into the role of DAMPs participating in a sterile immune response may provide greater insight into the pathogenesis of RAF. Markers evaluating immune cell activity, collagen deposition, and levels of heat shock proteins show the greatest promise as potential biomarkers to predict RAF and develop novel therapies.

Original languageEnglish (US)
Pages (from-to)193-207
Number of pages15
JournalExpert Review of Cardiovascular Therapy
Volume17
Issue number3
DOIs
StatePublished - Mar 4 2019

Fingerprint

Atrial Fibrillation
Biomarkers
Therapeutics
Heat-Shock Proteins
Collagen
Atrial Remodeling
Inflammation
Intraoperative Complications
Cardiac Myocytes
Cytokines
Morbidity
Mortality

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Immunopathogenesis and biomarkers of recurrent atrial fibrillation following ablation therapy in patients with preexisting atrial fibrillation. / Rosenberg, John H.; Werner, John H.; Plitt, Gilman D.; Noble, Victoria V.; Spring, Jordan T.; Stephens, Brooke A.; Siddique, Aleem; Merritt-Genore, Helenmari L.; Moulton, Michael J.; Agrawal, Devendra K.

In: Expert Review of Cardiovascular Therapy, Vol. 17, No. 3, 04.03.2019, p. 193-207.

Research output: Contribution to journalReview article

Rosenberg, JH, Werner, JH, Plitt, GD, Noble, VV, Spring, JT, Stephens, BA, Siddique, A, Merritt-Genore, HL, Moulton, MJ & Agrawal, DK 2019, 'Immunopathogenesis and biomarkers of recurrent atrial fibrillation following ablation therapy in patients with preexisting atrial fibrillation', Expert Review of Cardiovascular Therapy, vol. 17, no. 3, pp. 193-207. https://doi.org/10.1080/14779072.2019.1562902
Rosenberg, John H. ; Werner, John H. ; Plitt, Gilman D. ; Noble, Victoria V. ; Spring, Jordan T. ; Stephens, Brooke A. ; Siddique, Aleem ; Merritt-Genore, Helenmari L. ; Moulton, Michael J. ; Agrawal, Devendra K. / Immunopathogenesis and biomarkers of recurrent atrial fibrillation following ablation therapy in patients with preexisting atrial fibrillation. In: Expert Review of Cardiovascular Therapy. 2019 ; Vol. 17, No. 3. pp. 193-207.
@article{f4819717cf524c398c58fa89d63b848d,
title = "Immunopathogenesis and biomarkers of recurrent atrial fibrillation following ablation therapy in patients with preexisting atrial fibrillation",
abstract = "Introduction: Recurrent atrial fibrillation (RAF) following ablation therapy occurs in about 50{\%} of patients. The pathogenesis of RAF is unknown, but is believed to be driven by atrial remodeling in the setting of background inflammation. Structural, electrophysiological and mechanical remodeling has been associated with atrial fibrillation (AF). Inflammation and fibrotic remodeling are the major factors perpetuating AF, as mediators released from the atrial tissues and cardiomyocytes due to mechanical and surgical injury could initiate the inflammatory process. In this article, we have critically reviewed the key mediators that may serve as potential biomarkers to predict RAF. Areas covered: Damage associated molecular patterns, heat shock proteins, inflammatory cytokines, non-inflammatory markers, markers of inflammatory cell activity, and markers of collagen deposition and metabolism are evaluated as potential biomarkers with molecular treatment options in RAF. Expert commentary: Establishing biomarkers to predict RAF could be useful in reducing morbidity and mortality. Investigations into the role of DAMPs participating in a sterile immune response may provide greater insight into the pathogenesis of RAF. Markers evaluating immune cell activity, collagen deposition, and levels of heat shock proteins show the greatest promise as potential biomarkers to predict RAF and develop novel therapies.",
author = "Rosenberg, {John H.} and Werner, {John H.} and Plitt, {Gilman D.} and Noble, {Victoria V.} and Spring, {Jordan T.} and Stephens, {Brooke A.} and Aleem Siddique and Merritt-Genore, {Helenmari L.} and Moulton, {Michael J.} and Agrawal, {Devendra K.}",
year = "2019",
month = "3",
day = "4",
doi = "10.1080/14779072.2019.1562902",
language = "English (US)",
volume = "17",
pages = "193--207",
journal = "Expert Review of Cardiovascular Therapy",
issn = "1477-9072",
publisher = "Expert Reviews Ltd.",
number = "3",

}

TY - JOUR

T1 - Immunopathogenesis and biomarkers of recurrent atrial fibrillation following ablation therapy in patients with preexisting atrial fibrillation

AU - Rosenberg, John H.

AU - Werner, John H.

AU - Plitt, Gilman D.

AU - Noble, Victoria V.

AU - Spring, Jordan T.

AU - Stephens, Brooke A.

AU - Siddique, Aleem

AU - Merritt-Genore, Helenmari L.

AU - Moulton, Michael J.

AU - Agrawal, Devendra K.

PY - 2019/3/4

Y1 - 2019/3/4

N2 - Introduction: Recurrent atrial fibrillation (RAF) following ablation therapy occurs in about 50% of patients. The pathogenesis of RAF is unknown, but is believed to be driven by atrial remodeling in the setting of background inflammation. Structural, electrophysiological and mechanical remodeling has been associated with atrial fibrillation (AF). Inflammation and fibrotic remodeling are the major factors perpetuating AF, as mediators released from the atrial tissues and cardiomyocytes due to mechanical and surgical injury could initiate the inflammatory process. In this article, we have critically reviewed the key mediators that may serve as potential biomarkers to predict RAF. Areas covered: Damage associated molecular patterns, heat shock proteins, inflammatory cytokines, non-inflammatory markers, markers of inflammatory cell activity, and markers of collagen deposition and metabolism are evaluated as potential biomarkers with molecular treatment options in RAF. Expert commentary: Establishing biomarkers to predict RAF could be useful in reducing morbidity and mortality. Investigations into the role of DAMPs participating in a sterile immune response may provide greater insight into the pathogenesis of RAF. Markers evaluating immune cell activity, collagen deposition, and levels of heat shock proteins show the greatest promise as potential biomarkers to predict RAF and develop novel therapies.

AB - Introduction: Recurrent atrial fibrillation (RAF) following ablation therapy occurs in about 50% of patients. The pathogenesis of RAF is unknown, but is believed to be driven by atrial remodeling in the setting of background inflammation. Structural, electrophysiological and mechanical remodeling has been associated with atrial fibrillation (AF). Inflammation and fibrotic remodeling are the major factors perpetuating AF, as mediators released from the atrial tissues and cardiomyocytes due to mechanical and surgical injury could initiate the inflammatory process. In this article, we have critically reviewed the key mediators that may serve as potential biomarkers to predict RAF. Areas covered: Damage associated molecular patterns, heat shock proteins, inflammatory cytokines, non-inflammatory markers, markers of inflammatory cell activity, and markers of collagen deposition and metabolism are evaluated as potential biomarkers with molecular treatment options in RAF. Expert commentary: Establishing biomarkers to predict RAF could be useful in reducing morbidity and mortality. Investigations into the role of DAMPs participating in a sterile immune response may provide greater insight into the pathogenesis of RAF. Markers evaluating immune cell activity, collagen deposition, and levels of heat shock proteins show the greatest promise as potential biomarkers to predict RAF and develop novel therapies.

UR - http://www.scopus.com/inward/record.url?scp=85061982544&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061982544&partnerID=8YFLogxK

U2 - 10.1080/14779072.2019.1562902

DO - 10.1080/14779072.2019.1562902

M3 - Review article

VL - 17

SP - 193

EP - 207

JO - Expert Review of Cardiovascular Therapy

JF - Expert Review of Cardiovascular Therapy

SN - 1477-9072

IS - 3

ER -