IMP-27, a unique metallo-β-lactamase identified in geographically distinct isolates of Proteus mirabilis

Nyssa Dixon; Randal C. Fowler; A. Yoshizumi; Tsukasa Horiyama; Y. Ishii; Lucas Harrison; Chelsie N. Geyer; Ellen Smith Moland; Kenneth Thomson; Nancy D. Hanson

doi:10.1128/AAC.02945-15

IMP-27, a unique metallo-β-lactamase identified in geographically distinct isolates of Proteus mirabilis

Nyssa Dixon, Randal C. Fowler, A. Yoshizumi, Tsukasa Horiyama, Y. Ishii, Lucas Harrison, Chelsie N. Geyer, Ellen Smith Moland, Kenneth Thomson, Nancy D. Hanson

Department of Medical Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

A novel metallo-β-lactamase gene, bla_IMP-27, was identified in unrelated Proteus mirabilis isolates from two geographically distinct locations in the United States. Both isolates harbor bla_IMP-27 as part of the first gene cassette in a class 2 integron. Antimicrobial susceptibility testing indicated susceptibility to aztreonam, piperacillin-tazobactam, and ceftazidime but resistance to ertapenem. However, hydrolysis assays indicated that ceftazidime was a substrate for IMP-27.

Original language	English (US)
Pages (from-to)	6418-6421
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	60
Issue number	10
DOIs	https://doi.org/10.1128/AAC.02945-15
State	Published - Oct 2016

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

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title = "IMP-27, a unique metallo-β-lactamase identified in geographically distinct isolates of Proteus mirabilis",

abstract = "A novel metallo-β-lactamase gene, blaIMP-27, was identified in unrelated Proteus mirabilis isolates from two geographically distinct locations in the United States. Both isolates harbor blaIMP-27 as part of the first gene cassette in a class 2 integron. Antimicrobial susceptibility testing indicated susceptibility to aztreonam, piperacillin-tazobactam, and ceftazidime but resistance to ertapenem. However, hydrolysis assays indicated that ceftazidime was a substrate for IMP-27.",

author = "Nyssa Dixon and Fowler, {Randal C.} and A. Yoshizumi and Tsukasa Horiyama and Y. Ishii and Lucas Harrison and Geyer, {Chelsie N.} and Moland, {Ellen Smith} and Kenneth Thomson and Hanson, {Nancy D.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2016 Dixon et al.",

year = "2016",

month = oct,

doi = "10.1128/AAC.02945-15",

language = "English (US)",

volume = "60",

pages = "6418--6421",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

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TY - JOUR

T1 - IMP-27, a unique metallo-β-lactamase identified in geographically distinct isolates of Proteus mirabilis

AU - Dixon, Nyssa

AU - Fowler, Randal C.

AU - Yoshizumi, A.

AU - Horiyama, Tsukasa

AU - Ishii, Y.

AU - Harrison, Lucas

AU - Geyer, Chelsie N.

AU - Moland, Ellen Smith

AU - Thomson, Kenneth

AU - Hanson, Nancy D.

PY - 2016/10

Y1 - 2016/10

N2 - A novel metallo-β-lactamase gene, blaIMP-27, was identified in unrelated Proteus mirabilis isolates from two geographically distinct locations in the United States. Both isolates harbor blaIMP-27 as part of the first gene cassette in a class 2 integron. Antimicrobial susceptibility testing indicated susceptibility to aztreonam, piperacillin-tazobactam, and ceftazidime but resistance to ertapenem. However, hydrolysis assays indicated that ceftazidime was a substrate for IMP-27.

AB - A novel metallo-β-lactamase gene, blaIMP-27, was identified in unrelated Proteus mirabilis isolates from two geographically distinct locations in the United States. Both isolates harbor blaIMP-27 as part of the first gene cassette in a class 2 integron. Antimicrobial susceptibility testing indicated susceptibility to aztreonam, piperacillin-tazobactam, and ceftazidime but resistance to ertapenem. However, hydrolysis assays indicated that ceftazidime was a substrate for IMP-27.

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EP - 6421

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 10

ER -

IMP-27, a unique metallo-β-lactamase identified in geographically distinct isolates of Proteus mirabilis

Abstract

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