IMP-27, a unique metallo-β-lactamase identified in geographically distinct isolates of Proteus mirabilis

Nyssa Dixon; Randal C. Fowler; A. Yoshizumi; Tsukasa Horiyama; Y. Ishii; Lucas Harrison; Chelsie N. Geyer; Ellen Smith Moland; Kenneth Thomson; Nancy D. Hanson

doi:10.1128/AAC.02945-15

IMP-27, a unique metallo-β-lactamase identified in geographically distinct isolates of Proteus mirabilis

Nyssa Dixon, Randal C. Fowler, A. Yoshizumi, Tsukasa Horiyama, Y. Ishii, Lucas Harrison, Chelsie N. Geyer, Ellen Smith Moland, Kenneth Thomson, Nancy D. Hanson

Department of Medical Microbiology and Immunology

Research output: Contribution to journal › Article

7 Scopus citations

Abstract

A novel metallo-β-lactamase gene, bla_IMP-27, was identified in unrelated Proteus mirabilis isolates from two geographically distinct locations in the United States. Both isolates harbor bla_IMP-27 as part of the first gene cassette in a class 2 integron. Antimicrobial susceptibility testing indicated susceptibility to aztreonam, piperacillin-tazobactam, and ceftazidime but resistance to ertapenem. However, hydrolysis assays indicated that ceftazidime was a substrate for IMP-27.

Original language	English (US)
Pages (from-to)	6418-6421
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	60
Issue number	10
DOIs	https://doi.org/10.1128/AAC.02945-15
State	Published - Oct 2016

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Dixon, N., Fowler, R. C., Yoshizumi, A., Horiyama, T., Ishii, Y., Harrison, L., Geyer, C. N., Moland, E. S., Thomson, K., & Hanson, N. D. (2016). IMP-27, a unique metallo-β-lactamase identified in geographically distinct isolates of Proteus mirabilis. Antimicrobial agents and chemotherapy, 60(10), 6418-6421. https://doi.org/10.1128/AAC.02945-15

IMP-27, a unique metallo-β-lactamase identified in geographically distinct isolates of Proteus mirabilis. / Dixon, Nyssa; Fowler, Randal C.; Yoshizumi, A.; Horiyama, Tsukasa; Ishii, Y.; Harrison, Lucas; Geyer, Chelsie N.; Moland, Ellen Smith; Thomson, Kenneth; Hanson, Nancy D.

In: Antimicrobial agents and chemotherapy, Vol. 60, No. 10, 10.2016, p. 6418-6421.

Research output: Contribution to journal › Article

Dixon, Nyssa ; Fowler, Randal C. ; Yoshizumi, A. ; Horiyama, Tsukasa ; Ishii, Y. ; Harrison, Lucas ; Geyer, Chelsie N. ; Moland, Ellen Smith ; Thomson, Kenneth ; Hanson, Nancy D. / IMP-27, a unique metallo-β-lactamase identified in geographically distinct isolates of Proteus mirabilis. In: Antimicrobial agents and chemotherapy. 2016 ; Vol. 60, No. 10. pp. 6418-6421.

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abstract = "A novel metallo-β-lactamase gene, blaIMP-27, was identified in unrelated Proteus mirabilis isolates from two geographically distinct locations in the United States. Both isolates harbor blaIMP-27 as part of the first gene cassette in a class 2 integron. Antimicrobial susceptibility testing indicated susceptibility to aztreonam, piperacillin-tazobactam, and ceftazidime but resistance to ertapenem. However, hydrolysis assays indicated that ceftazidime was a substrate for IMP-27.",

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