Abstract
A novel metallo-β-lactamase gene, blaIMP-27, was identified in unrelated Proteus mirabilis isolates from two geographically distinct locations in the United States. Both isolates harbor blaIMP-27 as part of the first gene cassette in a class 2 integron. Antimicrobial susceptibility testing indicated susceptibility to aztreonam, piperacillin-tazobactam, and ceftazidime but resistance to ertapenem. However, hydrolysis assays indicated that ceftazidime was a substrate for IMP-27.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 6418-6421 |
| Number of pages | 4 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 60 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1 2016 |
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All Science Journal Classification (ASJC) codes
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases
Cite this
IMP-27, a unique metallo-β-lactamase identified in geographically distinct isolates of Proteus mirabilis. / Dixon, Nyssa; Fowler, Randal C.; Yoshizumi, A.; Horiyama, Tsukasa; Ishii, Y.; Harrison, Lucas; Geyer, Chelsie N.; Moland, Ellen Smith; Thomson, Kenneth; Hanson, Nancy D.
In: Antimicrobial Agents and Chemotherapy, Vol. 60, No. 10, 01.10.2016, p. 6418-6421.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - IMP-27, a unique metallo-β-lactamase identified in geographically distinct isolates of Proteus mirabilis
AU - Dixon, Nyssa
AU - Fowler, Randal C.
AU - Yoshizumi, A.
AU - Horiyama, Tsukasa
AU - Ishii, Y.
AU - Harrison, Lucas
AU - Geyer, Chelsie N.
AU - Moland, Ellen Smith
AU - Thomson, Kenneth
AU - Hanson, Nancy D.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - A novel metallo-β-lactamase gene, blaIMP-27, was identified in unrelated Proteus mirabilis isolates from two geographically distinct locations in the United States. Both isolates harbor blaIMP-27 as part of the first gene cassette in a class 2 integron. Antimicrobial susceptibility testing indicated susceptibility to aztreonam, piperacillin-tazobactam, and ceftazidime but resistance to ertapenem. However, hydrolysis assays indicated that ceftazidime was a substrate for IMP-27.
AB - A novel metallo-β-lactamase gene, blaIMP-27, was identified in unrelated Proteus mirabilis isolates from two geographically distinct locations in the United States. Both isolates harbor blaIMP-27 as part of the first gene cassette in a class 2 integron. Antimicrobial susceptibility testing indicated susceptibility to aztreonam, piperacillin-tazobactam, and ceftazidime but resistance to ertapenem. However, hydrolysis assays indicated that ceftazidime was a substrate for IMP-27.
UR - http://www.scopus.com/inward/record.url?scp=84992559951&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84992559951&partnerID=8YFLogxK
U2 - 10.1128/AAC.02945-15
DO - 10.1128/AAC.02945-15
M3 - Article
C2 - 27503648
AN - SCOPUS:84992559951
VL - 60
SP - 6418
EP - 6421
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 10
ER -