Impact of a clinical pharmacokinetic service on patients treated with aminoglycosides: A cost-benefit analysis

Christopher J. Destache, Sharon K. Meyer, Marvin J. Bittner, Kenneth G. Hermann

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

In a prospective, randomized study, 75 adults receiving aminogly-cosides were followed by a clinical pharmacokinetic service and 70 followed as controls. The two groups were similar in age, gender, height, and APACHE II score. A cost-to-charge ratio was used to derive direct costs of hospitalization and calculate cost-benefit. Excluded from this comparison were patients with incomplete acceptance of pharmacokinetic service recommendations and patients followed by other clinical pharmacists. Pharmacokinetic service patients had shorter hospitalizations (322.67 ± 270.28 h; controls 442.89 ± 536.81, p = 0.087) and febrile periods (50.05 ± 79.38 h; controls 92.23 ± 122.50, p <0.05). More pharmacokinetic service patients had adequate peak levels. Pharmacokinetic service direct costs were lower (7,102.56 ± 9,898.19; controls 13,758.64 ± 22,874.31, p <0.05). Calculated direct cost of the service was 85.00/patient. Annual savings for 500 patients is 2,220,540.00.

Original languageEnglish (US)
Pages (from-to)419-426
Number of pages8
JournalTherapeutic Drug Monitoring
Volume12
Issue number5
DOIs
StatePublished - Sep 1990

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

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