Abstract
BACKGROUND: The thrombolysis-in-myocardial-infarction risk score (TRS) is a validated risk-assessment tool based on randomized clinical trials. Its applicability to an unselected group of patients seen in general clinical practice may be limited as renal dysfunction was an exclusion criteria in the original trials upon which the TRS was determined. MATERIALS AND METHODS: Consecutive patients with non-ST elevation acute coronary syndrome were stratified based on renal function. Normal renal function was defined as a creatinine clearance (CrCl) of more than 60 ml/min, moderate renal dysfunction was defined as a CrCl of at least 30 ml/min but 60 ml/min or less, and severe renal dysfunction was defined as a CrCl of less than 30 ml/min. A TRS was calculated using the original seven criteria (TRS-7) which did not consider renal function. A second TRS was calculated using the original seven criteria plus the addition of renal dysfunction if the CrCl was 60 ml/min or less (TRS-8≤60). A third TRS was calculated using the original seven criteria plus renal dysfunction if the CrCl was less than 30 ml/min (TRS-80.05). At a calculated TRS of 6 or 7, the TRS-8
| Original language | English |
|---|---|
| Pages (from-to) | 411-415 |
| Number of pages | 5 |
| Journal | Coronary Artery Disease |
| Volume | 22 |
| Issue number | 6 |
| DOIs | |
| State | Published - Sep 2011 |
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All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
Cite this
Impact of renal dysfunction on the prognostic value of the TIMI risk score in patients with non-ST elevation acute coronary syndrome. / Go, Jason; Narmi, Ann; Sype, John; Mooss, Aryan N.; Hilleman, Daniel E.
In: Coronary Artery Disease, Vol. 22, No. 6, 09.2011, p. 411-415.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Impact of renal dysfunction on the prognostic value of the TIMI risk score in patients with non-ST elevation acute coronary syndrome
AU - Go, Jason
AU - Narmi, Ann
AU - Sype, John
AU - Mooss, Aryan N.
AU - Hilleman, Daniel E.
PY - 2011/9
Y1 - 2011/9
N2 - BACKGROUND: The thrombolysis-in-myocardial-infarction risk score (TRS) is a validated risk-assessment tool based on randomized clinical trials. Its applicability to an unselected group of patients seen in general clinical practice may be limited as renal dysfunction was an exclusion criteria in the original trials upon which the TRS was determined. MATERIALS AND METHODS: Consecutive patients with non-ST elevation acute coronary syndrome were stratified based on renal function. Normal renal function was defined as a creatinine clearance (CrCl) of more than 60 ml/min, moderate renal dysfunction was defined as a CrCl of at least 30 ml/min but 60 ml/min or less, and severe renal dysfunction was defined as a CrCl of less than 30 ml/min. A TRS was calculated using the original seven criteria (TRS-7) which did not consider renal function. A second TRS was calculated using the original seven criteria plus the addition of renal dysfunction if the CrCl was 60 ml/min or less (TRS-8≤60). A third TRS was calculated using the original seven criteria plus renal dysfunction if the CrCl was less than 30 ml/min (TRS-80.05). At a calculated TRS of 6 or 7, the TRS-8
AB - BACKGROUND: The thrombolysis-in-myocardial-infarction risk score (TRS) is a validated risk-assessment tool based on randomized clinical trials. Its applicability to an unselected group of patients seen in general clinical practice may be limited as renal dysfunction was an exclusion criteria in the original trials upon which the TRS was determined. MATERIALS AND METHODS: Consecutive patients with non-ST elevation acute coronary syndrome were stratified based on renal function. Normal renal function was defined as a creatinine clearance (CrCl) of more than 60 ml/min, moderate renal dysfunction was defined as a CrCl of at least 30 ml/min but 60 ml/min or less, and severe renal dysfunction was defined as a CrCl of less than 30 ml/min. A TRS was calculated using the original seven criteria (TRS-7) which did not consider renal function. A second TRS was calculated using the original seven criteria plus the addition of renal dysfunction if the CrCl was 60 ml/min or less (TRS-8≤60). A third TRS was calculated using the original seven criteria plus renal dysfunction if the CrCl was less than 30 ml/min (TRS-80.05). At a calculated TRS of 6 or 7, the TRS-8
UR - http://www.scopus.com/inward/record.url?scp=80051796898&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80051796898&partnerID=8YFLogxK
U2 - 10.1097/MCA.0b013e3283487de2
DO - 10.1097/MCA.0b013e3283487de2
M3 - Article
VL - 22
SP - 411
EP - 415
JO - Coronary Artery Disease
JF - Coronary Artery Disease
SN - 0954-6928
IS - 6
ER -