Implantable insulin pump vs multiple-dose insulin for non-insulin- dependent diabetes mellitus: A randomized clinical trial

Christopher D. Saudek, William C. Duckworth, Anita Giobbie-Hurder, William G. Henderson, Robert R. Henry, David E. Kelley, Steven V. Edelman, Franklin J. Zieve, Robert A. Adler, James W. Anderson, Robert J. Anderson, Bruce P. Hamilton, Thomas W. Donner, M. Sue Kirkman, Nancy A. Morgan

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

Objective. - To determine whether implantable insulin pump (IIP) therapy and multiple daily insulin (MDI) injections could equally attain improved blood glucose control, and to compare the 2 treatments with respect to reducing daily blood glucose fluctuations, reducing serious hypoglycemic insulin reactions, and improving patients' quality of life. Design. - Randomized clinical trial. Setting. - Seven Veterans Affairs medical centers. Patients. - One hundred twenty-one male type II diabetic patients between the ages of 40 and 69 years, receiving at least 1 injection of insulin per day and having hemoglobin A(1c) (HbA(1c)) levels of 8% or above. Intervention. - Intensive therapy (IIP or MDI) for 1 year. Main Outcome Measures. - Hemoglobin A(1c) and blood glucose levels. Results. - Blood glucose levels declined to 7.96±1.08 mmol/L (143.4±19.5 mg/dL) and 8.30± 1.52 mmol/L (149.6±27.4 mg/dL) (mean ± SD) for IIP and MDI, respectively (P=.57). Hemoglobin A(1c) levels improved in both groups (time effect P

Original languageEnglish
Pages (from-to)1322-1327
Number of pages6
JournalJAMA - Journal of the American Medical Association
Volume276
Issue number16
DOIs
StatePublished - Oct 23 1996

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Type 2 Diabetes Mellitus
Randomized Controlled Trials
Insulin
Hemoglobin A
Blood Glucose
Injections
Veterans
Hypoglycemic Agents
Therapeutics
Quality of Life
Outcome Assessment (Health Care)

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Saudek, C. D., Duckworth, W. C., Giobbie-Hurder, A., Henderson, W. G., Henry, R. R., Kelley, D. E., ... Morgan, N. A. (1996). Implantable insulin pump vs multiple-dose insulin for non-insulin- dependent diabetes mellitus: A randomized clinical trial. JAMA - Journal of the American Medical Association, 276(16), 1322-1327. https://doi.org/10.1001/jama.276.16.1322

Implantable insulin pump vs multiple-dose insulin for non-insulin- dependent diabetes mellitus : A randomized clinical trial. / Saudek, Christopher D.; Duckworth, William C.; Giobbie-Hurder, Anita; Henderson, William G.; Henry, Robert R.; Kelley, David E.; Edelman, Steven V.; Zieve, Franklin J.; Adler, Robert A.; Anderson, James W.; Anderson, Robert J.; Hamilton, Bruce P.; Donner, Thomas W.; Kirkman, M. Sue; Morgan, Nancy A.

In: JAMA - Journal of the American Medical Association, Vol. 276, No. 16, 23.10.1996, p. 1322-1327.

Research output: Contribution to journalArticle

Saudek, CD, Duckworth, WC, Giobbie-Hurder, A, Henderson, WG, Henry, RR, Kelley, DE, Edelman, SV, Zieve, FJ, Adler, RA, Anderson, JW, Anderson, RJ, Hamilton, BP, Donner, TW, Kirkman, MS & Morgan, NA 1996, 'Implantable insulin pump vs multiple-dose insulin for non-insulin- dependent diabetes mellitus: A randomized clinical trial', JAMA - Journal of the American Medical Association, vol. 276, no. 16, pp. 1322-1327. https://doi.org/10.1001/jama.276.16.1322
Saudek, Christopher D. ; Duckworth, William C. ; Giobbie-Hurder, Anita ; Henderson, William G. ; Henry, Robert R. ; Kelley, David E. ; Edelman, Steven V. ; Zieve, Franklin J. ; Adler, Robert A. ; Anderson, James W. ; Anderson, Robert J. ; Hamilton, Bruce P. ; Donner, Thomas W. ; Kirkman, M. Sue ; Morgan, Nancy A. / Implantable insulin pump vs multiple-dose insulin for non-insulin- dependent diabetes mellitus : A randomized clinical trial. In: JAMA - Journal of the American Medical Association. 1996 ; Vol. 276, No. 16. pp. 1322-1327.
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