Importance of interleukin-3 on histamine release from human basophils

H. Sugiyama, R. Eda, R. J. Hopp, A. K. Bewtra, R. G. Townley

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


We investigated the effects of interleukin-3 (IL-3) on histamine release (direct releasing and indirect enhancing effects) from basophils in allergic asthmatic subjects. Interleukin-3 caused direct histamine release (HR) in selected donors (IL-3 responders) and enhanced anti-IgE-induced HR in other IL-3 nonresponders, although both direct releasing and indirect enhancing activities of IL-3 on HR did not coexist with each other. There was a significant correlation between IL-3-induced HR and spontaneous histamine release (r = .8532, P <.0001).

Original languageEnglish (US)
Pages (from-to)391-395
Number of pages5
JournalAnnals of allergy
Issue number4
StatePublished - 1993

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy


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