Importance of interleukin-3 on histamine release from human basophils

H. Sugiyama; R. Eda; R. J. Hopp; A. K. Bewtra; R. G. Townley

Importance of interleukin-3 on histamine release from human basophils

H. Sugiyama, R. Eda, R. J. Hopp, A. K. Bewtra, R. G. Townley

Department of Medicine

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

We investigated the effects of interleukin-3 (IL-3) on histamine release (direct releasing and indirect enhancing effects) from basophils in allergic asthmatic subjects. Interleukin-3 caused direct histamine release (HR) in selected donors (IL-3 responders) and enhanced anti-IgE-induced HR in other IL-3 nonresponders, although both direct releasing and indirect enhancing activities of IL-3 on HR did not coexist with each other. There was a significant correlation between IL-3-induced HR and spontaneous histamine release (r = .8532, P <.0001).

Original language	English (US)
Pages (from-to)	391-395
Number of pages	5
Journal	Annals of allergy
Volume	71
Issue number	4
State	Published - 1993

All Science Journal Classification (ASJC) codes

Immunology and Allergy

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abstract = "We investigated the effects of interleukin-3 (IL-3) on histamine release (direct releasing and indirect enhancing effects) from basophils in allergic asthmatic subjects. Interleukin-3 caused direct histamine release (HR) in selected donors (IL-3 responders) and enhanced anti-IgE-induced HR in other IL-3 nonresponders, although both direct releasing and indirect enhancing activities of IL-3 on HR did not coexist with each other. There was a significant correlation between IL-3-induced HR and spontaneous histamine release (r = .8532, P <.0001).",

author = "H. Sugiyama and R. Eda and Hopp, {R. J.} and Bewtra, {A. K.} and Townley, {R. G.}",

year = "1993",

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T1 - Importance of interleukin-3 on histamine release from human basophils

AU - Sugiyama, H.

AU - Eda, R.

AU - Hopp, R. J.

AU - Bewtra, A. K.

AU - Townley, R. G.

PY - 1993

Y1 - 1993

N2 - We investigated the effects of interleukin-3 (IL-3) on histamine release (direct releasing and indirect enhancing effects) from basophils in allergic asthmatic subjects. Interleukin-3 caused direct histamine release (HR) in selected donors (IL-3 responders) and enhanced anti-IgE-induced HR in other IL-3 nonresponders, although both direct releasing and indirect enhancing activities of IL-3 on HR did not coexist with each other. There was a significant correlation between IL-3-induced HR and spontaneous histamine release (r = .8532, P <.0001).

AB - We investigated the effects of interleukin-3 (IL-3) on histamine release (direct releasing and indirect enhancing effects) from basophils in allergic asthmatic subjects. Interleukin-3 caused direct histamine release (HR) in selected donors (IL-3 responders) and enhanced anti-IgE-induced HR in other IL-3 nonresponders, although both direct releasing and indirect enhancing activities of IL-3 on HR did not coexist with each other. There was a significant correlation between IL-3-induced HR and spontaneous histamine release (r = .8532, P <.0001).

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SN - 1081-1206

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