Abstract
We investigated the effects of interleukin-3 (IL-3) on histamine release (direct releasing and indirect enhancing effects) from basophils in allergic asthmatic subjects. Interleukin-3 caused direct histamine release (HR) in selected donors (IL-3 responders) and enhanced anti-IgE-induced HR in other IL-3 nonresponders, although both direct releasing and indirect enhancing activities of IL-3 on HR did not coexist with each other. There was a significant correlation between IL-3-induced HR and spontaneous histamine release (r = .8532, P <.0001).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 391-395 |
| Number of pages | 5 |
| Journal | Annals of allergy |
| Volume | 71 |
| Issue number | 4 |
| State | Published - 1993 |
All Science Journal Classification (ASJC) codes
- Immunology and Allergy
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Sugiyama, H., Eda, R., Hopp, R. J., Bewtra, A. K., & Townley, R. G. (1993). Importance of interleukin-3 on histamine release from human basophils. Annals of allergy, 71(4), 391-395.