Importance of interleukin-3 on histamine release from human basophils

H. Sugiyama, R. Eda, R. J. Hopp, Againdra K. Bewtra, R. G. Townley

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We investigated the effects of interleukin-3 (IL-3) on histamine release (direct releasing and indirect enhancing effects) from basophils in allergic asthmatic subjects. Interleukin-3 caused direct histamine release (HR) in selected donors (IL-3 responders) and enhanced anti-IgE-induced HR in other IL-3 nonresponders, although both direct releasing and indirect enhancing activities of IL-3 on HR did not coexist with each other. There was a significant correlation between IL-3-induced HR and spontaneous histamine release (r = .8532, P <.0001).

Original languageEnglish
Pages (from-to)391-395
Number of pages5
JournalAnnals of Allergy
Volume71
Issue number4
StatePublished - 1993

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Basophils
Histamine Release
Interleukin-3

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy

Cite this

Sugiyama, H., Eda, R., Hopp, R. J., Bewtra, A. K., & Townley, R. G. (1993). Importance of interleukin-3 on histamine release from human basophils. Annals of Allergy, 71(4), 391-395.

Importance of interleukin-3 on histamine release from human basophils. / Sugiyama, H.; Eda, R.; Hopp, R. J.; Bewtra, Againdra K.; Townley, R. G.

In: Annals of Allergy, Vol. 71, No. 4, 1993, p. 391-395.

Research output: Contribution to journalArticle

Sugiyama, H, Eda, R, Hopp, RJ, Bewtra, AK & Townley, RG 1993, 'Importance of interleukin-3 on histamine release from human basophils', Annals of Allergy, vol. 71, no. 4, pp. 391-395.
Sugiyama, H. ; Eda, R. ; Hopp, R. J. ; Bewtra, Againdra K. ; Townley, R. G. / Importance of interleukin-3 on histamine release from human basophils. In: Annals of Allergy. 1993 ; Vol. 71, No. 4. pp. 391-395.
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