Abstract
We investigated the effects of interleukin-3 (IL-3) on histamine release (direct releasing and indirect enhancing effects) from basophils in allergic asthmatic subjects. Interleukin-3 caused direct histamine release (HR) in selected donors (IL-3 responders) and enhanced anti-IgE-induced HR in other IL-3 nonresponders, although both direct releasing and indirect enhancing activities of IL-3 on HR did not coexist with each other. There was a significant correlation between IL-3-induced HR and spontaneous histamine release (r = .8532, P <.0001).
| Original language | English |
|---|---|
| Pages (from-to) | 391-395 |
| Number of pages | 5 |
| Journal | Annals of Allergy |
| Volume | 71 |
| Issue number | 4 |
| State | Published - 1993 |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
Cite this
Importance of interleukin-3 on histamine release from human basophils. / Sugiyama, H.; Eda, R.; Hopp, R. J.; Bewtra, Againdra K.; Townley, R. G.
In: Annals of Allergy, Vol. 71, No. 4, 1993, p. 391-395.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Importance of interleukin-3 on histamine release from human basophils
AU - Sugiyama, H.
AU - Eda, R.
AU - Hopp, R. J.
AU - Bewtra, Againdra K.
AU - Townley, R. G.
PY - 1993
Y1 - 1993
N2 - We investigated the effects of interleukin-3 (IL-3) on histamine release (direct releasing and indirect enhancing effects) from basophils in allergic asthmatic subjects. Interleukin-3 caused direct histamine release (HR) in selected donors (IL-3 responders) and enhanced anti-IgE-induced HR in other IL-3 nonresponders, although both direct releasing and indirect enhancing activities of IL-3 on HR did not coexist with each other. There was a significant correlation between IL-3-induced HR and spontaneous histamine release (r = .8532, P <.0001).
AB - We investigated the effects of interleukin-3 (IL-3) on histamine release (direct releasing and indirect enhancing effects) from basophils in allergic asthmatic subjects. Interleukin-3 caused direct histamine release (HR) in selected donors (IL-3 responders) and enhanced anti-IgE-induced HR in other IL-3 nonresponders, although both direct releasing and indirect enhancing activities of IL-3 on HR did not coexist with each other. There was a significant correlation between IL-3-induced HR and spontaneous histamine release (r = .8532, P <.0001).
UR - http://www.scopus.com/inward/record.url?scp=0027363390&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027363390&partnerID=8YFLogxK
M3 - Article
VL - 71
SP - 391
EP - 395
JO - Annals of Allergy, Asthma and Immunology
JF - Annals of Allergy, Asthma and Immunology
SN - 1081-1206
IS - 4
ER -