Important prognostic factors in leiomyosarcoma survival: a National Cancer Database (NCDB) analysis

J. Gootee, N. Sioda, S. Aurit, C. Curtin, P. Silberstein

Research output: Contribution to journalArticle

Abstract

Background: Leiomyosarcoma (LMS) is an aggressive, malignant mesenchymal tumor with characteristic smooth muscle lineage accounting for 10–20% of all soft tissue tumors. The goal of this study is to determine the impact of prognostic factors on leiomyosarcoma survival irrespective of primary anatomical site. Methods: There were a total of 7154 patients with primary leiomyosarcoma identified and analyzed from the National Cancer Database. Descriptive statistics, median survival, and 5- and 10-year survival probabilities were calculated along with a Cox proportional hazard model to determine independent prognostic factors. Results: In this study, females comprised 68.3% of the cohort with a median age of 58 years. The most common primary anatomical sites were the extremities followed by female reproductive organs, abdomen, pelvis, thorax or lung, and head or neck. Tumors localized in the female reproductive organs had the worst survival (5-year survival probability: 45.3%), while tumors localized in the extremities had the best survival outcomes (5-year survival probability: 73.4%). Surgery with adjuvant radiation yielded better outcomes compared to surgery alone (HR 0.82, 95% CI 0.74–0.91). Microscopic and macroscopic margins resulted in a 32% and a 134% increased risk in mortality, respectively, when compared to negative surgical margins (p < 0.0001). Conclusion: This study showed a significantly higher risk of mortality associated with older patients, tumors localized to the female reproductive organs, African American patients, higher tumor stage, increased Charlson/Deyo scores, tumors treated with surgery alone without adjuvant radiation, and tumors with positive microscopic, macroscopic, or indeterminate surgical margins.

Original languageEnglish (US)
JournalClinical and Translational Oncology
DOIs
StateAccepted/In press - Jan 1 2019
Externally publishedYes

Fingerprint

Leiomyosarcoma
Databases
Survival
Neoplasms
Extremities
Radiation
Mortality
Pelvis
Proportional Hazards Models
African Americans
Abdomen
Smooth Muscle
Neck
Thorax
Head
Lung

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Important prognostic factors in leiomyosarcoma survival : a National Cancer Database (NCDB) analysis. / Gootee, J.; Sioda, N.; Aurit, S.; Curtin, C.; Silberstein, P.

In: Clinical and Translational Oncology, 01.01.2019.

Research output: Contribution to journalArticle

@article{104b35d9344642e69a5d9abedc893464,
title = "Important prognostic factors in leiomyosarcoma survival: a National Cancer Database (NCDB) analysis",
abstract = "Background: Leiomyosarcoma (LMS) is an aggressive, malignant mesenchymal tumor with characteristic smooth muscle lineage accounting for 10–20{\%} of all soft tissue tumors. The goal of this study is to determine the impact of prognostic factors on leiomyosarcoma survival irrespective of primary anatomical site. Methods: There were a total of 7154 patients with primary leiomyosarcoma identified and analyzed from the National Cancer Database. Descriptive statistics, median survival, and 5- and 10-year survival probabilities were calculated along with a Cox proportional hazard model to determine independent prognostic factors. Results: In this study, females comprised 68.3{\%} of the cohort with a median age of 58 years. The most common primary anatomical sites were the extremities followed by female reproductive organs, abdomen, pelvis, thorax or lung, and head or neck. Tumors localized in the female reproductive organs had the worst survival (5-year survival probability: 45.3{\%}), while tumors localized in the extremities had the best survival outcomes (5-year survival probability: 73.4{\%}). Surgery with adjuvant radiation yielded better outcomes compared to surgery alone (HR 0.82, 95{\%} CI 0.74–0.91). Microscopic and macroscopic margins resulted in a 32{\%} and a 134{\%} increased risk in mortality, respectively, when compared to negative surgical margins (p < 0.0001). Conclusion: This study showed a significantly higher risk of mortality associated with older patients, tumors localized to the female reproductive organs, African American patients, higher tumor stage, increased Charlson/Deyo scores, tumors treated with surgery alone without adjuvant radiation, and tumors with positive microscopic, macroscopic, or indeterminate surgical margins.",
author = "J. Gootee and N. Sioda and S. Aurit and C. Curtin and P. Silberstein",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s12094-019-02196-7",
language = "English (US)",
journal = "Clinical and Translational Oncology",
issn = "1699-048X",
publisher = "Springer-Verlag Italia",

}

TY - JOUR

T1 - Important prognostic factors in leiomyosarcoma survival

T2 - a National Cancer Database (NCDB) analysis

AU - Gootee, J.

AU - Sioda, N.

AU - Aurit, S.

AU - Curtin, C.

AU - Silberstein, P.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Leiomyosarcoma (LMS) is an aggressive, malignant mesenchymal tumor with characteristic smooth muscle lineage accounting for 10–20% of all soft tissue tumors. The goal of this study is to determine the impact of prognostic factors on leiomyosarcoma survival irrespective of primary anatomical site. Methods: There were a total of 7154 patients with primary leiomyosarcoma identified and analyzed from the National Cancer Database. Descriptive statistics, median survival, and 5- and 10-year survival probabilities were calculated along with a Cox proportional hazard model to determine independent prognostic factors. Results: In this study, females comprised 68.3% of the cohort with a median age of 58 years. The most common primary anatomical sites were the extremities followed by female reproductive organs, abdomen, pelvis, thorax or lung, and head or neck. Tumors localized in the female reproductive organs had the worst survival (5-year survival probability: 45.3%), while tumors localized in the extremities had the best survival outcomes (5-year survival probability: 73.4%). Surgery with adjuvant radiation yielded better outcomes compared to surgery alone (HR 0.82, 95% CI 0.74–0.91). Microscopic and macroscopic margins resulted in a 32% and a 134% increased risk in mortality, respectively, when compared to negative surgical margins (p < 0.0001). Conclusion: This study showed a significantly higher risk of mortality associated with older patients, tumors localized to the female reproductive organs, African American patients, higher tumor stage, increased Charlson/Deyo scores, tumors treated with surgery alone without adjuvant radiation, and tumors with positive microscopic, macroscopic, or indeterminate surgical margins.

AB - Background: Leiomyosarcoma (LMS) is an aggressive, malignant mesenchymal tumor with characteristic smooth muscle lineage accounting for 10–20% of all soft tissue tumors. The goal of this study is to determine the impact of prognostic factors on leiomyosarcoma survival irrespective of primary anatomical site. Methods: There were a total of 7154 patients with primary leiomyosarcoma identified and analyzed from the National Cancer Database. Descriptive statistics, median survival, and 5- and 10-year survival probabilities were calculated along with a Cox proportional hazard model to determine independent prognostic factors. Results: In this study, females comprised 68.3% of the cohort with a median age of 58 years. The most common primary anatomical sites were the extremities followed by female reproductive organs, abdomen, pelvis, thorax or lung, and head or neck. Tumors localized in the female reproductive organs had the worst survival (5-year survival probability: 45.3%), while tumors localized in the extremities had the best survival outcomes (5-year survival probability: 73.4%). Surgery with adjuvant radiation yielded better outcomes compared to surgery alone (HR 0.82, 95% CI 0.74–0.91). Microscopic and macroscopic margins resulted in a 32% and a 134% increased risk in mortality, respectively, when compared to negative surgical margins (p < 0.0001). Conclusion: This study showed a significantly higher risk of mortality associated with older patients, tumors localized to the female reproductive organs, African American patients, higher tumor stage, increased Charlson/Deyo scores, tumors treated with surgery alone without adjuvant radiation, and tumors with positive microscopic, macroscopic, or indeterminate surgical margins.

UR - http://www.scopus.com/inward/record.url?scp=85070575503&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070575503&partnerID=8YFLogxK

U2 - 10.1007/s12094-019-02196-7

DO - 10.1007/s12094-019-02196-7

M3 - Article

AN - SCOPUS:85070575503

JO - Clinical and Translational Oncology

JF - Clinical and Translational Oncology

SN - 1699-048X

ER -