Abstract
Nucleocytoplasmic shuttling of macromolecules is a well-controlled process involving importins and exportins. These karyopherins recognize and bind to receptor-mediated intracellular signals through specific signal sequences that are present on cargo proteins and transport into and out of the nucleus through nuclear pore complexes. Nuclear localization signals (NLS) present on cargo molecules to be imported while nuclear export signals (NES) on the molecules to be exported are recognized by importins and exportins, respectively. The classical NLS are found on many transcription factors and molecules that are involved in the pathogenesis of allergic diseases. In addition, several immune modulators, including corticosteroids and vitamin D, elicit their cellular responses by regulating the expression and activity of importin molecules. In this review article, we provide a comprehensive list of importin and exportin molecules and their specific cargo that shuttled between cytoplasm and the nucleus. We also critically review the role and regulation of specific importin and exportin involved in the transport of activated transcription factors in allergic diseases, the underlying molecular mechanisms, and the potential target sites for developing better therapeutic approaches.
| Original language | English |
|---|---|
| Article number | 476357 |
| Journal | Mediators of Inflammation |
| Volume | 2014 |
| DOIs | |
| State | Published - 2014 |
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All Science Journal Classification (ASJC) codes
- Immunology
- Cell Biology
- Medicine(all)
Cite this
Importins and exportins regulating allergic immune responses. / Aggarwal, Ankita; Agrawal, Devendra K.
In: Mediators of Inflammation, Vol. 2014, 476357, 2014.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Importins and exportins regulating allergic immune responses
AU - Aggarwal, Ankita
AU - Agrawal, Devendra K.
PY - 2014
Y1 - 2014
N2 - Nucleocytoplasmic shuttling of macromolecules is a well-controlled process involving importins and exportins. These karyopherins recognize and bind to receptor-mediated intracellular signals through specific signal sequences that are present on cargo proteins and transport into and out of the nucleus through nuclear pore complexes. Nuclear localization signals (NLS) present on cargo molecules to be imported while nuclear export signals (NES) on the molecules to be exported are recognized by importins and exportins, respectively. The classical NLS are found on many transcription factors and molecules that are involved in the pathogenesis of allergic diseases. In addition, several immune modulators, including corticosteroids and vitamin D, elicit their cellular responses by regulating the expression and activity of importin molecules. In this review article, we provide a comprehensive list of importin and exportin molecules and their specific cargo that shuttled between cytoplasm and the nucleus. We also critically review the role and regulation of specific importin and exportin involved in the transport of activated transcription factors in allergic diseases, the underlying molecular mechanisms, and the potential target sites for developing better therapeutic approaches.
AB - Nucleocytoplasmic shuttling of macromolecules is a well-controlled process involving importins and exportins. These karyopherins recognize and bind to receptor-mediated intracellular signals through specific signal sequences that are present on cargo proteins and transport into and out of the nucleus through nuclear pore complexes. Nuclear localization signals (NLS) present on cargo molecules to be imported while nuclear export signals (NES) on the molecules to be exported are recognized by importins and exportins, respectively. The classical NLS are found on many transcription factors and molecules that are involved in the pathogenesis of allergic diseases. In addition, several immune modulators, including corticosteroids and vitamin D, elicit their cellular responses by regulating the expression and activity of importin molecules. In this review article, we provide a comprehensive list of importin and exportin molecules and their specific cargo that shuttled between cytoplasm and the nucleus. We also critically review the role and regulation of specific importin and exportin involved in the transport of activated transcription factors in allergic diseases, the underlying molecular mechanisms, and the potential target sites for developing better therapeutic approaches.
UR - http://www.scopus.com/inward/record.url?scp=84897533544&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84897533544&partnerID=8YFLogxK
U2 - 10.1155/2014/476357
DO - 10.1155/2014/476357
M3 - Article
C2 - 24733961
AN - SCOPUS:84897533544
VL - 2014
JO - Mediators of Inflammation
JF - Mediators of Inflammation
SN - 0962-9351
M1 - 476357
ER -