In stent restenosis: Bane of the stent era

A. K. Mitra, Devendra K. Agrawal

Research output: Contribution to journalReview articlepeer-review

221 Scopus citations


The long term outcome of stent implantation is affected by a process called in stent restenosis (ISR). Multiple contributory factors have been identified, but clear understanding of the overall underlying mechanism remains an enigma. ISR progresses through several different phases and involves numerous cellular and molecular constituents. Platelets and macrophages play a central role via vascular smooth muscle cell migration and proliferation in the intima to produce neointimal hyperplasia, which is pathognomic of ISR. Increased extracellular matrix formation appears to form the bulk of the neointimal hyperplasia tissue. Emerging evidence of the role of inflammatory cytokines and suppressors of cytokine signalling make this an exciting and novel field of antirestenosis research. Activation of Akt pathway triggered by mechanical stretch may also be a contributory factor to ISR formation. Prevention of ISR appears to be a multipronged attack as no therapeutic "magic bullet" exists to block all the processes in one go.

Original languageEnglish
Pages (from-to)232-239
Number of pages8
JournalJournal of Clinical Pathology - Clinical Molecular Pathology
Issue number3
StatePublished - Mar 2006

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine


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