In vitro-controlled release delivery system for hydrogen sulfide donor

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Hydrogen sulfide (H2S) is having many potential pharmacological and physiological actions which reported that therapeutically useful concentration is low (100-160 μM) and a higher concentration could be toxic. Most of its donors produce it on coming into contact with water. All of these problems could be solved by a controlled-release delivery system which does not utilize water in any of its development steps. Therefore, 12 sustained release formulations were prepared by dissolving sodium hydrogen sulfide (NaHS) - a model H2S donor - in polymer solutions, prepared by dissolving polymers (consisted of either polylactide (PLA) or polylactide co-glycolide (PLGA), containing free carboxylic acid or capped allyl ester end group) in a mixture of benzyl benzoate (BB) and benzyl alcohol (BA). The formulation was injected in simulated tear fluid (STF) from which samples were withdrawn at specified times and assayed for NaHS content. We found decrease in burst and overall release with increase in polymer concentration from 10 to 20% w/v. The formulations containing free end group showed significant (p2S was found to be maintained for 72 h which should be further increased to a month to make it a viable H2S donor delivery system in addition to investigating toxicity profile specifically for the purpose of subconjunctival ocular delivery.

Original languageEnglish
Pages (from-to)910-919
Number of pages10
JournalAAPS PharmSciTech
Volume15
Issue number4
DOIs
StatePublished - 2014

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Hydrogen Sulfide
hydrogen sulfide
polymers
Polymers
sodium sulfide
benzyl benzoate
Benzyl Alcohol
benzyl alcohol
Water
Poisons
carboxylic acids
Carboxylic Acids
Tears
Esters
water
eyes
esters
Pharmacology
toxicity
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science
  • Medicine(all)

Cite this

In vitro-controlled release delivery system for hydrogen sulfide donor. / Ali, Hatim; Opere, Catherine A.; Singh, Somnath.

In: AAPS PharmSciTech, Vol. 15, No. 4, 2014, p. 910-919.

Research output: Contribution to journalArticle

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