In vitro drug interference with home blood-glucose-measurement systems

G. K. Rice, Kimberly A. Galt

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The in vitro effects of ascorbic acid, acetaminophen, salicylic acid, and gentisic acid on home blood-glucose-measurement systems were studied. Whole blood in the normoglycemic range was spiked with quantities of each study drug at low, moderate, and high therapeutic concentrations. The glucose concentrations of the blood was measured using Chemstrip bG, Dextrostix, and Visidex II home blood-glucose-monitoring systems. Serum samples were also measured by two automated systems, a glucose-oxidase method and a hexokinase method. Mean values were compared (1) within the same glucose-measurement system to determine the extent of drug interference, and (2) to values obtained by other systems to determine the reliability among systems. Changes between the control and treatment glucose mean concentrations of 20% or more were considered clinically important. Drug interference was observed with all three home blood-glucose-measurement systems and was drug-concentration dependent. Both automated systems were associated with drug interference at the highest concentration of salicyclic acid, and the hexokinase method was influenced at the highest concentration of gentisic acid. No clinically important differences were observed between the automated systems; however, differences were observed between the automated and home blood-glucose-monitoring systems. Salicylic acid, acetaminophen, and ascorbic acid interfere with home blood-glucose-measurement systems. Switching between home blood-glucose-measurement systems could result in a poor assessment of blood-glucose values. In general, the values determined by home and automated systems should not be compared clinically.

Original languageEnglish
Pages (from-to)2202-2207
Number of pages6
JournalAmerican Journal of Hospital Pharmacy
Volume42
Issue number10
StatePublished - 1985
Externally publishedYes

Fingerprint

Blood Glucose
Pharmaceutical Preparations
Blood Glucose Self-Monitoring
Hexokinase
Salicylic Acid
Acetaminophen
Ascorbic Acid
Glucose
Glucose Oxidase
In Vitro Techniques
Acids
Therapeutics
Serum
2,5-dihydroxybenzoic acid

All Science Journal Classification (ASJC) codes

  • Leadership and Management
  • Pharmaceutical Science

Cite this

In vitro drug interference with home blood-glucose-measurement systems. / Rice, G. K.; Galt, Kimberly A.

In: American Journal of Hospital Pharmacy, Vol. 42, No. 10, 1985, p. 2202-2207.

Research output: Contribution to journalArticle

@article{2a087afa8312410ab0ce3d7ba376d383,
title = "In vitro drug interference with home blood-glucose-measurement systems",
abstract = "The in vitro effects of ascorbic acid, acetaminophen, salicylic acid, and gentisic acid on home blood-glucose-measurement systems were studied. Whole blood in the normoglycemic range was spiked with quantities of each study drug at low, moderate, and high therapeutic concentrations. The glucose concentrations of the blood was measured using Chemstrip bG, Dextrostix, and Visidex II home blood-glucose-monitoring systems. Serum samples were also measured by two automated systems, a glucose-oxidase method and a hexokinase method. Mean values were compared (1) within the same glucose-measurement system to determine the extent of drug interference, and (2) to values obtained by other systems to determine the reliability among systems. Changes between the control and treatment glucose mean concentrations of 20{\%} or more were considered clinically important. Drug interference was observed with all three home blood-glucose-measurement systems and was drug-concentration dependent. Both automated systems were associated with drug interference at the highest concentration of salicyclic acid, and the hexokinase method was influenced at the highest concentration of gentisic acid. No clinically important differences were observed between the automated systems; however, differences were observed between the automated and home blood-glucose-monitoring systems. Salicylic acid, acetaminophen, and ascorbic acid interfere with home blood-glucose-measurement systems. Switching between home blood-glucose-measurement systems could result in a poor assessment of blood-glucose values. In general, the values determined by home and automated systems should not be compared clinically.",
author = "Rice, {G. K.} and Galt, {Kimberly A.}",
year = "1985",
language = "English",
volume = "42",
pages = "2202--2207",
journal = "American Journal of Health-System Pharmacy",
issn = "1079-2082",
publisher = "American Society of Health-Systems Pharmacy",
number = "10",

}

TY - JOUR

T1 - In vitro drug interference with home blood-glucose-measurement systems

AU - Rice, G. K.

AU - Galt, Kimberly A.

PY - 1985

Y1 - 1985

N2 - The in vitro effects of ascorbic acid, acetaminophen, salicylic acid, and gentisic acid on home blood-glucose-measurement systems were studied. Whole blood in the normoglycemic range was spiked with quantities of each study drug at low, moderate, and high therapeutic concentrations. The glucose concentrations of the blood was measured using Chemstrip bG, Dextrostix, and Visidex II home blood-glucose-monitoring systems. Serum samples were also measured by two automated systems, a glucose-oxidase method and a hexokinase method. Mean values were compared (1) within the same glucose-measurement system to determine the extent of drug interference, and (2) to values obtained by other systems to determine the reliability among systems. Changes between the control and treatment glucose mean concentrations of 20% or more were considered clinically important. Drug interference was observed with all three home blood-glucose-measurement systems and was drug-concentration dependent. Both automated systems were associated with drug interference at the highest concentration of salicyclic acid, and the hexokinase method was influenced at the highest concentration of gentisic acid. No clinically important differences were observed between the automated systems; however, differences were observed between the automated and home blood-glucose-monitoring systems. Salicylic acid, acetaminophen, and ascorbic acid interfere with home blood-glucose-measurement systems. Switching between home blood-glucose-measurement systems could result in a poor assessment of blood-glucose values. In general, the values determined by home and automated systems should not be compared clinically.

AB - The in vitro effects of ascorbic acid, acetaminophen, salicylic acid, and gentisic acid on home blood-glucose-measurement systems were studied. Whole blood in the normoglycemic range was spiked with quantities of each study drug at low, moderate, and high therapeutic concentrations. The glucose concentrations of the blood was measured using Chemstrip bG, Dextrostix, and Visidex II home blood-glucose-monitoring systems. Serum samples were also measured by two automated systems, a glucose-oxidase method and a hexokinase method. Mean values were compared (1) within the same glucose-measurement system to determine the extent of drug interference, and (2) to values obtained by other systems to determine the reliability among systems. Changes between the control and treatment glucose mean concentrations of 20% or more were considered clinically important. Drug interference was observed with all three home blood-glucose-measurement systems and was drug-concentration dependent. Both automated systems were associated with drug interference at the highest concentration of salicyclic acid, and the hexokinase method was influenced at the highest concentration of gentisic acid. No clinically important differences were observed between the automated systems; however, differences were observed between the automated and home blood-glucose-monitoring systems. Salicylic acid, acetaminophen, and ascorbic acid interfere with home blood-glucose-measurement systems. Switching between home blood-glucose-measurement systems could result in a poor assessment of blood-glucose values. In general, the values determined by home and automated systems should not be compared clinically.

UR - http://www.scopus.com/inward/record.url?scp=0021921071&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021921071&partnerID=8YFLogxK

M3 - Article

C2 - 4061463

AN - SCOPUS:0021921071

VL - 42

SP - 2202

EP - 2207

JO - American Journal of Health-System Pharmacy

JF - American Journal of Health-System Pharmacy

SN - 1079-2082

IS - 10

ER -