In-vivo measurement of osteoporotic bone fragility with apparent velocity of ultrasound

G. Brandenburger, L. Avioli, C. Chesnut, R. Heaney, R. Poss, G. Pratt, R. Recker

Research output: Contribution to journalConference articlepeer-review

2 Scopus citations


Loss of mechanical strength due to bone conditions such as osteoporosis causes spontaneous fractures despite the absence of significant physical trauma. Well-established theory and in vitro experiment suggest the potential for ultrasound velocity to assess such deterioration of bone strength. Nevertheless, technical obstacles have precluded in vivo application until recently. A novel approach is described for achieving accuracy and reproducibility by overcoming difficulties with inhomogeneity, anisotropy, overlying soft tissue, and multipath propagation. Key elements of the design include anatomical-site selection, propagation-path determination, ultrasound generation and detection, digital signal processing, and apparent-velocity estimation.

Original languageEnglish (US)
Pages (from-to)1023-1027
Number of pages5
JournalUltrasonics Symposium Proceedings
StatePublished - Dec 1 1989
EventIEEE 1989 Ultrasonics Symposium - Montreal, Que, Can
Duration: Oct 3 1989Oct 6 1989

All Science Journal Classification (ASJC) codes

  • Engineering(all)


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