TY - JOUR
T1 - In-vivo measurement of osteoporotic bone fragility with apparent velocity of ultrasound
AU - Brandenburger, G.
AU - Avioli, L.
AU - Chesnut, C.
AU - Heaney, R.
AU - Poss, R.
AU - Pratt, G.
AU - Recker, R.
PY - 1989/12/1
Y1 - 1989/12/1
N2 - Loss of mechanical strength due to bone conditions such as osteoporosis causes spontaneous fractures despite the absence of significant physical trauma. Well-established theory and in vitro experiment suggest the potential for ultrasound velocity to assess such deterioration of bone strength. Nevertheless, technical obstacles have precluded in vivo application until recently. A novel approach is described for achieving accuracy and reproducibility by overcoming difficulties with inhomogeneity, anisotropy, overlying soft tissue, and multipath propagation. Key elements of the design include anatomical-site selection, propagation-path determination, ultrasound generation and detection, digital signal processing, and apparent-velocity estimation.
AB - Loss of mechanical strength due to bone conditions such as osteoporosis causes spontaneous fractures despite the absence of significant physical trauma. Well-established theory and in vitro experiment suggest the potential for ultrasound velocity to assess such deterioration of bone strength. Nevertheless, technical obstacles have precluded in vivo application until recently. A novel approach is described for achieving accuracy and reproducibility by overcoming difficulties with inhomogeneity, anisotropy, overlying soft tissue, and multipath propagation. Key elements of the design include anatomical-site selection, propagation-path determination, ultrasound generation and detection, digital signal processing, and apparent-velocity estimation.
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M3 - Conference article
AN - SCOPUS:0024871752
VL - 2
SP - 1023
EP - 1027
JO - Ultrasonics Symposium Proceedings
JF - Ultrasonics Symposium Proceedings
SN - 0090-5607
T2 - IEEE 1989 Ultrasonics Symposium
Y2 - 3 October 1989 through 6 October 1989
ER -