In vivo percutaneous absorption, skin barrier perturbation, and irritation from JP-8 jet fuel components

Somnath Singh, Kaidi Zhao, Jagdish Singh

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

JP-8 jet fuel has been reported to cause systemic and dermal toxicities in animal models and humans. There is a great potential for human exposure to JP-8. In this study, we determined percutaneous absorption and dermal toxicity of three components of JP-8 (i.e., xylene, heptane, and hexadecane) in vivo in weanling pigs. In vivo percutaneous absorption results suggest a greater absorption of hexadecane (0.43%) than xylene (0.17%) or heptane (0.14%) of the applied dose after 30 min exposure. Transepidermal water loss (TEWL) provides a robust method for assessing damage to the stratum corneum. Heptane showed greater increase in TEWL than the other two chemicals. No significant (p <0.05) increase in temperature was observed at the chemically treated site than the control site. Heptane showed greater TEWL values and erythema score than other two chemicals (xylene and hexadecane). We did not observe any skin reactions or edema from these chemicals. Erythema was completely resolved after 24 h of the patch removal in case of xylene and hexadecane.

Original languageEnglish
Pages (from-to)135-146
Number of pages12
JournalDrug and Chemical Toxicology
Volume26
Issue number2
DOIs
StatePublished - 2003

Fingerprint

Skin Absorption
Heptanes
Xylenes
Jet fuel
Heptane
Xylene
Skin
Erythema
Toxicity
Water
Cornea
Edema
Animals
Swine
Animal Models
Temperature
n-hexadecane
JP8 aviation fuel

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Pharmacology
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

In vivo percutaneous absorption, skin barrier perturbation, and irritation from JP-8 jet fuel components. / Singh, Somnath; Zhao, Kaidi; Singh, Jagdish.

In: Drug and Chemical Toxicology, Vol. 26, No. 2, 2003, p. 135-146.

Research output: Contribution to journalArticle

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