In vivo strain application in rat tibiae using non-invasive loading method

M. P. Akhter, D. M. Raab, C. H. Turner, D. B. Kimmel, R. R. Recker

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This study characterized a non-invasive method of applying mechanical strain to the tibiae of rats. A four-point bending device was used to induce mechanical strain non-invasively in an 11 mm section of the right tibiae of 10 female Sprague-Dawley rats. Induced strains were measured in vivo at various locations along the rat tibia to establish a relationship between induced strain and applied load. Finite element analysis was used to quantify the magnitude of shear stresses in the rat tibia due to four-point bending. The in vivo measured strains were highly correlated with the calculated strains using beam bending theory (r2 = 0.87). The finite element model predicted shear stresses to be less than 10 percent of the longitudinal stresses resulting from the four-point bending.

Original languageEnglish (US)
Title of host publication1991 Advances in Bioengineering
PublisherPubl by ASME
Pages353-355
Number of pages3
ISBN (Print)0791808890
StatePublished - Dec 1 1991
EventWinter Annual Meeting of the American Society of Mechanical Engineers - Atlanta, GA, USA
Duration: Dec 1 1991Dec 6 1991

Publication series

NameAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Volume20

Other

OtherWinter Annual Meeting of the American Society of Mechanical Engineers
CityAtlanta, GA, USA
Period12/1/9112/6/91

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All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Akhter, M. P., Raab, D. M., Turner, C. H., Kimmel, D. B., & Recker, R. R. (1991). In vivo strain application in rat tibiae using non-invasive loading method. In 1991 Advances in Bioengineering (pp. 353-355). (American Society of Mechanical Engineers, Bioengineering Division (Publication) BED; Vol. 20). Publ by ASME.