Abstract
This study characterized a non-invasive method of applying mechanical strain to the tibiae of rats. A four-point bending device was used to induce mechanical strain non-invasively in an 11 mm section of the right tibiae of 10 female Sprague-Dawley rats. Induced strains were measured in vivo at various locations along the rat tibia to establish a relationship between induced strain and applied load. Finite element analysis was used to quantify the magnitude of shear stresses in the rat tibia due to four-point bending. The in vivo measured strains were highly correlated with the calculated strains using beam bending theory (r2 = 0.87). The finite element model predicted shear stresses to be less than 10 percent of the longitudinal stresses resulting from the four-point bending.
| Original language | English |
|---|---|
| Title of host publication | 1991 Advances in Bioengineering |
| Publisher | Publ by ASME |
| Pages | 353-355 |
| Number of pages | 3 |
| Volume | 20 |
| ISBN (Print) | 0791808890 |
| State | Published - 1991 |
| Event | Winter Annual Meeting of the American Society of Mechanical Engineers - Atlanta, GA, USA Duration: Dec 1 1991 → Dec 6 1991 |
Other
| Other | Winter Annual Meeting of the American Society of Mechanical Engineers |
|---|---|
| City | Atlanta, GA, USA |
| Period | 12/1/91 → 12/6/91 |
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All Science Journal Classification (ASJC) codes
- Engineering(all)
Cite this
In vivo strain application in rat tibiae using non-invasive loading method. / Akhter, Mohammed P.; Raab, D. M.; Turner, C. H.; Kimmel, D. B.; Recker, Robert R.
1991 Advances in Bioengineering. Vol. 20 Publ by ASME, 1991. p. 353-355.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - In vivo strain application in rat tibiae using non-invasive loading method
AU - Akhter, Mohammed P.
AU - Raab, D. M.
AU - Turner, C. H.
AU - Kimmel, D. B.
AU - Recker, Robert R.
PY - 1991
Y1 - 1991
N2 - This study characterized a non-invasive method of applying mechanical strain to the tibiae of rats. A four-point bending device was used to induce mechanical strain non-invasively in an 11 mm section of the right tibiae of 10 female Sprague-Dawley rats. Induced strains were measured in vivo at various locations along the rat tibia to establish a relationship between induced strain and applied load. Finite element analysis was used to quantify the magnitude of shear stresses in the rat tibia due to four-point bending. The in vivo measured strains were highly correlated with the calculated strains using beam bending theory (r2 = 0.87). The finite element model predicted shear stresses to be less than 10 percent of the longitudinal stresses resulting from the four-point bending.
AB - This study characterized a non-invasive method of applying mechanical strain to the tibiae of rats. A four-point bending device was used to induce mechanical strain non-invasively in an 11 mm section of the right tibiae of 10 female Sprague-Dawley rats. Induced strains were measured in vivo at various locations along the rat tibia to establish a relationship between induced strain and applied load. Finite element analysis was used to quantify the magnitude of shear stresses in the rat tibia due to four-point bending. The in vivo measured strains were highly correlated with the calculated strains using beam bending theory (r2 = 0.87). The finite element model predicted shear stresses to be less than 10 percent of the longitudinal stresses resulting from the four-point bending.
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M3 - Conference contribution
SN - 0791808890
VL - 20
SP - 353
EP - 355
BT - 1991 Advances in Bioengineering
PB - Publ by ASME
ER -