Incidence of colorectal cancer in BRCA1 and BRCA2 mutation carriers

Results from a follow-up study

C. M. Phelan, J. Iqbal, Henry T. Lynch, J. Lubinski, J. Gronwald, P. Moller, P. Ghadirian, W. D. Foulkes, S. Armel, A. Eisen, S. L. Neuhausen, L. Senter, C. F. Singer, P. Ainsworth, C. Kim-Sing, N. Tung, M. Llacuachaqui, G. Chornokur, S. Ping, S. A. Narod

Research output: Contribution to journalArticle

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Abstract

Background:The BRCA1 and BRCA2 genes confer increased susceptibility to breast and ovarian cancer and to a spectrum of other cancers. There is controversy regarding the risk of colorectal cancer conferred by germline mutations in these two genes.Methods:We followed 7015 women with a BRCA mutation for new cases of colorectal cancer. Incidence rates in carriers were compared with population-specific incidence rates, and standardised incidence ratios (SIRs) were estimated. The expected numbers of cancers were computed by multiplying person-years at risk by the appropriate age-, sex-and country-specific incidence rates from the five countries.Results:Twenty-one incident colorectal cancer cases were observed among all mutation carriers, compared with 23.6 cases expected. The SIR for BRCA1 carriers was 0.92 (95% confidence interval (CI), 0.54-1.40, P=0.7) and for BRCA2 carriers was 0.82 (95% CI, 0.30-1.81, P=0.7). The SIR for colon cancer was 3.81 (95% CI 1.77-7.23) for women below the age of 50 years (both genes combined) and was 0.60 (95% CI 0.33-1.00) for women aged 50 years and above.Conclusion:The risk of colorectal cancer is increased in female carriers of BRCA1 mutations below the age of 50 years but not in women with BRCA2 mutations or in older women.

Original languageEnglish
Pages (from-to)530-534
Number of pages5
JournalBritish Journal of Cancer
Volume110
Issue number2
DOIs
StatePublished - Jan 21 2014

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Colorectal Neoplasms
Mutation
Incidence
Confidence Intervals
BRCA2 Gene
BRCA1 Gene
Germ-Line Mutation
Ovarian Neoplasms
Colonic Neoplasms
Genes
Neoplasms
Breast Neoplasms
Population

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Incidence of colorectal cancer in BRCA1 and BRCA2 mutation carriers : Results from a follow-up study. / Phelan, C. M.; Iqbal, J.; Lynch, Henry T.; Lubinski, J.; Gronwald, J.; Moller, P.; Ghadirian, P.; Foulkes, W. D.; Armel, S.; Eisen, A.; Neuhausen, S. L.; Senter, L.; Singer, C. F.; Ainsworth, P.; Kim-Sing, C.; Tung, N.; Llacuachaqui, M.; Chornokur, G.; Ping, S.; Narod, S. A.

In: British Journal of Cancer, Vol. 110, No. 2, 21.01.2014, p. 530-534.

Research output: Contribution to journalArticle

Phelan, CM, Iqbal, J, Lynch, HT, Lubinski, J, Gronwald, J, Moller, P, Ghadirian, P, Foulkes, WD, Armel, S, Eisen, A, Neuhausen, SL, Senter, L, Singer, CF, Ainsworth, P, Kim-Sing, C, Tung, N, Llacuachaqui, M, Chornokur, G, Ping, S & Narod, SA 2014, 'Incidence of colorectal cancer in BRCA1 and BRCA2 mutation carriers: Results from a follow-up study', British Journal of Cancer, vol. 110, no. 2, pp. 530-534. https://doi.org/10.1038/bjc.2013.741
Phelan, C. M. ; Iqbal, J. ; Lynch, Henry T. ; Lubinski, J. ; Gronwald, J. ; Moller, P. ; Ghadirian, P. ; Foulkes, W. D. ; Armel, S. ; Eisen, A. ; Neuhausen, S. L. ; Senter, L. ; Singer, C. F. ; Ainsworth, P. ; Kim-Sing, C. ; Tung, N. ; Llacuachaqui, M. ; Chornokur, G. ; Ping, S. ; Narod, S. A. / Incidence of colorectal cancer in BRCA1 and BRCA2 mutation carriers : Results from a follow-up study. In: British Journal of Cancer. 2014 ; Vol. 110, No. 2. pp. 530-534.
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abstract = "Background:The BRCA1 and BRCA2 genes confer increased susceptibility to breast and ovarian cancer and to a spectrum of other cancers. There is controversy regarding the risk of colorectal cancer conferred by germline mutations in these two genes.Methods:We followed 7015 women with a BRCA mutation for new cases of colorectal cancer. Incidence rates in carriers were compared with population-specific incidence rates, and standardised incidence ratios (SIRs) were estimated. The expected numbers of cancers were computed by multiplying person-years at risk by the appropriate age-, sex-and country-specific incidence rates from the five countries.Results:Twenty-one incident colorectal cancer cases were observed among all mutation carriers, compared with 23.6 cases expected. The SIR for BRCA1 carriers was 0.92 (95{\%} confidence interval (CI), 0.54-1.40, P=0.7) and for BRCA2 carriers was 0.82 (95{\%} CI, 0.30-1.81, P=0.7). The SIR for colon cancer was 3.81 (95{\%} CI 1.77-7.23) for women below the age of 50 years (both genes combined) and was 0.60 (95{\%} CI 0.33-1.00) for women aged 50 years and above.Conclusion:The risk of colorectal cancer is increased in female carriers of BRCA1 mutations below the age of 50 years but not in women with BRCA2 mutations or in older women.",
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T1 - Incidence of colorectal cancer in BRCA1 and BRCA2 mutation carriers

T2 - Results from a follow-up study

AU - Phelan, C. M.

AU - Iqbal, J.

AU - Lynch, Henry T.

AU - Lubinski, J.

AU - Gronwald, J.

AU - Moller, P.

AU - Ghadirian, P.

AU - Foulkes, W. D.

AU - Armel, S.

AU - Eisen, A.

AU - Neuhausen, S. L.

AU - Senter, L.

AU - Singer, C. F.

AU - Ainsworth, P.

AU - Kim-Sing, C.

AU - Tung, N.

AU - Llacuachaqui, M.

AU - Chornokur, G.

AU - Ping, S.

AU - Narod, S. A.

PY - 2014/1/21

Y1 - 2014/1/21

N2 - Background:The BRCA1 and BRCA2 genes confer increased susceptibility to breast and ovarian cancer and to a spectrum of other cancers. There is controversy regarding the risk of colorectal cancer conferred by germline mutations in these two genes.Methods:We followed 7015 women with a BRCA mutation for new cases of colorectal cancer. Incidence rates in carriers were compared with population-specific incidence rates, and standardised incidence ratios (SIRs) were estimated. The expected numbers of cancers were computed by multiplying person-years at risk by the appropriate age-, sex-and country-specific incidence rates from the five countries.Results:Twenty-one incident colorectal cancer cases were observed among all mutation carriers, compared with 23.6 cases expected. The SIR for BRCA1 carriers was 0.92 (95% confidence interval (CI), 0.54-1.40, P=0.7) and for BRCA2 carriers was 0.82 (95% CI, 0.30-1.81, P=0.7). The SIR for colon cancer was 3.81 (95% CI 1.77-7.23) for women below the age of 50 years (both genes combined) and was 0.60 (95% CI 0.33-1.00) for women aged 50 years and above.Conclusion:The risk of colorectal cancer is increased in female carriers of BRCA1 mutations below the age of 50 years but not in women with BRCA2 mutations or in older women.

AB - Background:The BRCA1 and BRCA2 genes confer increased susceptibility to breast and ovarian cancer and to a spectrum of other cancers. There is controversy regarding the risk of colorectal cancer conferred by germline mutations in these two genes.Methods:We followed 7015 women with a BRCA mutation for new cases of colorectal cancer. Incidence rates in carriers were compared with population-specific incidence rates, and standardised incidence ratios (SIRs) were estimated. The expected numbers of cancers were computed by multiplying person-years at risk by the appropriate age-, sex-and country-specific incidence rates from the five countries.Results:Twenty-one incident colorectal cancer cases were observed among all mutation carriers, compared with 23.6 cases expected. The SIR for BRCA1 carriers was 0.92 (95% confidence interval (CI), 0.54-1.40, P=0.7) and for BRCA2 carriers was 0.82 (95% CI, 0.30-1.81, P=0.7). The SIR for colon cancer was 3.81 (95% CI 1.77-7.23) for women below the age of 50 years (both genes combined) and was 0.60 (95% CI 0.33-1.00) for women aged 50 years and above.Conclusion:The risk of colorectal cancer is increased in female carriers of BRCA1 mutations below the age of 50 years but not in women with BRCA2 mutations or in older women.

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