Incidence rate of type 2 diabetes is >50% lower in GrassrootsHealth cohort with median serum 25-hydroxyvitamin D of 41 ng/ml than in NHANES cohort with median of 22 ng/ml

S. L. McDonnell; L. L. Baggerly; C. B. French; R. P. Heaney; E. D. Gorham; M. F. Holick; R. Scragg; C. F. Garland

doi:10.1016/j.jsbmb.2015.06.013

Incidence rate of type 2 diabetes is >50% lower in GrassrootsHealth cohort with median serum 25-hydroxyvitamin D of 41 ng/ml than in NHANES cohort with median of 22 ng/ml

S. L. McDonnell, L. L. Baggerly, C. B. French, R. P. Heaney, E. D. Gorham, M. F. Holick, R. Scragg, C. F. Garland

Department of Medicine

Research output: Contribution to journal › Article

7 Scopus citations

Abstract

Higher serum 25-hydroxyvitamin D [25(OH)D] concentrations have been associated with lower risk of type 2 diabetes. This study compared incidence rates of type 2 diabetes among participants aged ≥20 years in two U.S. cohorts with markedly different median 25(OH)D concentrations. The median 25(OH)D concentration in the GrassrootsHealth (GRH) cohort was 41 ng/ml (N = 4933) while in the 2005-6 National Health and Nutrition Examination Survey (NHANES) it was 22 ng/ml (N = 4078) (P <0.0001). The adjusted annual incidence rate of type 2 diabetes was 3.7 per 1000 population (95% confidence interval = 1.9, 6.6) in the GRH cohort, compared to 9.3 per 1000 population (95% confidence interval = 6.7, 12.6) in NHANES. In the NHANES cohort, the lowest 25(OH)D tertiles (

Original language	English (US)
Pages (from-to)	239-244
Number of pages	6
Journal	Journal of Steroid Biochemistry and Molecular Biology
Volume	155
DOIs	https://doi.org/10.1016/j.jsbmb.2015.06.013
State	Published - Jan 1 2016

All Science Journal Classification (ASJC) codes

Endocrinology, Diabetes and Metabolism
Biochemistry
Molecular Medicine
Molecular Biology
Endocrinology
Clinical Biochemistry
Cell Biology

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McDonnell, S. L., Baggerly, L. L., French, C. B., Heaney, R. P., Gorham, E. D., Holick, M. F., Scragg, R., & Garland, C. F. (2016). Incidence rate of type 2 diabetes is >50% lower in GrassrootsHealth cohort with median serum 25-hydroxyvitamin D of 41 ng/ml than in NHANES cohort with median of 22 ng/ml. Journal of Steroid Biochemistry and Molecular Biology, 155, 239-244. https://doi.org/10.1016/j.jsbmb.2015.06.013

Incidence rate of type 2 diabetes is >50% lower in GrassrootsHealth cohort with median serum 25-hydroxyvitamin D of 41 ng/ml than in NHANES cohort with median of 22 ng/ml. / McDonnell, S. L.; Baggerly, L. L.; French, C. B.; Heaney, R. P.; Gorham, E. D.; Holick, M. F.; Scragg, R.; Garland, C. F.

In: Journal of Steroid Biochemistry and Molecular Biology, Vol. 155, 01.01.2016, p. 239-244.

Research output: Contribution to journal › Article

McDonnell, SL, Baggerly, LL, French, CB, Heaney, RP, Gorham, ED, Holick, MF, Scragg, R & Garland, CF 2016, 'Incidence rate of type 2 diabetes is >50% lower in GrassrootsHealth cohort with median serum 25-hydroxyvitamin D of 41 ng/ml than in NHANES cohort with median of 22 ng/ml', Journal of Steroid Biochemistry and Molecular Biology, vol. 155, pp. 239-244. https://doi.org/10.1016/j.jsbmb.2015.06.013

McDonnell SL, Baggerly LL, French CB, Heaney RP, Gorham ED, Holick MF et al. Incidence rate of type 2 diabetes is >50% lower in GrassrootsHealth cohort with median serum 25-hydroxyvitamin D of 41 ng/ml than in NHANES cohort with median of 22 ng/ml. Journal of Steroid Biochemistry and Molecular Biology. 2016 Jan 1;155:239-244. https://doi.org/10.1016/j.jsbmb.2015.06.013

McDonnell, S. L. ; Baggerly, L. L. ; French, C. B. ; Heaney, R. P. ; Gorham, E. D. ; Holick, M. F. ; Scragg, R. ; Garland, C. F. / Incidence rate of type 2 diabetes is >50% lower in GrassrootsHealth cohort with median serum 25-hydroxyvitamin D of 41 ng/ml than in NHANES cohort with median of 22 ng/ml. In: Journal of Steroid Biochemistry and Molecular Biology. 2016 ; Vol. 155. pp. 239-244.

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abstract = "Higher serum 25-hydroxyvitamin D [25(OH)D] concentrations have been associated with lower risk of type 2 diabetes. This study compared incidence rates of type 2 diabetes among participants aged ≥20 years in two U.S. cohorts with markedly different median 25(OH)D concentrations. The median 25(OH)D concentration in the GrassrootsHealth (GRH) cohort was 41 ng/ml (N = 4933) while in the 2005-6 National Health and Nutrition Examination Survey (NHANES) it was 22 ng/ml (N = 4078) (P <0.0001). The adjusted annual incidence rate of type 2 diabetes was 3.7 per 1000 population (95% confidence interval = 1.9, 6.6) in the GRH cohort, compared to 9.3 per 1000 population (95% confidence interval = 6.7, 12.6) in NHANES. In the NHANES cohort, the lowest 25(OH)D tertiles (",

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AU - French, C. B.

AU - Heaney, R. P.

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